Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Graeme J. Koelwyn"'
Autor:
Yushan Hu, Xiaojian Shao, Li Xing, Xuan Li, Geoffrey M. Nonis, Graeme J. Koelwyn, Xuekui Zhang, Don D. Sin
Publikováno v:
Cells, Vol 12, Iss 24, p 2771 (2023)
Background: Macrophages and monocytes orchestrate inflammatory processes in the lungs. However, their role in the pathogenesis of chronic obstructive pulmonary disease (COPD), an inflammatory condition, is not well known. Here, we determined the char
Externí odkaz:
https://doaj.org/article/2ead81e1a672432eaf50f7e1f0af7d53
Autor:
William Yip, Xuan Li, Graeme J. Koelwyn, Stephen Milne, Fernando Sergio Leitao Filho, Chen Xi Yang, Ana I. Hernández Cordero, Julia Yang, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Kelly M. McNagny, Don D. Sin
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1110 (2022)
Background: Patients with chronic obstructive pulmonary disease (COPD) are commonly treated with inhaled corticosteroid/long-acting ß2-agonist combination therapy. While previous studies have investigated the host–microbiome interactions in COPD,
Externí odkaz:
https://doaj.org/article/017237e0b7f04cc5b05b75260a171d9a
Publikováno v:
J Mol Cell Cardiol
The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior t
Autor:
KAREN C. TRAN, TERRY LEE, ADEERA LEVIN, CHRISTOPHER J. RYERSON, ALYSON WONG, DAVID SWEET, KEITH R. WALLEY, JOHN H. BOYD, JOEL SINGER, GRAEME J. KOELWYN, PUNEET MANN M Sc, KATHRYN DONOHOE B Sc, James Russell
BACKGROUND:Prediction of severity of Post-COVID-19 condition is not clear. We determined whether hospital course variables correlated with objective and subjective outcomes 3- and 6-months post-COVID-19 onset.METHODS:Adults admitted to hospital with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f6471ed753d06c9d2f449abbc884c8
https://doi.org/10.21203/rs.3.rs-1936634/v1
https://doi.org/10.21203/rs.3.rs-1936634/v1
Autor:
Liqian Ma, Hashni Epa Vidana Gamage, Srishti Tiwari, Chaeyeon Han, Madeline A Henn, Natalia Krawczynska, Payam Dibaeinia, Graeme J Koelwyn, Anasuya Das Gupta, Rafael Ovidio Bautista Rivas, Chris L Wright, Fangxiu Xu, Kathryn J Moore, Saurabh Sinha, Erik R Nelson
Publikováno v:
Endocrinology
Dysregulation of cholesterol homeostasis is associated with many diseases such as cardiovascular disease and cancer. Liver X receptors (LXRs) are major upstream regulators of cholesterol homeostasis and are activated by endogenous cholesterol metabol
Publikováno v:
Nat Metab
Unhealthful lifestyle factors, such as obesity, disrupt organismal homeostasis and accelerate cancer pathogenesis, partly through metabolic and immunological dysregulation. Exercise is a prototypical strategy that maintains and restores homeostasis a
Autor:
Tessa J Barrett, Emma Corr, Coen Solingen, Florencia Schlamp, Emily J Brown, Graeme J KOELWYN, Angela Lee, Lianne Shanley, Tanya Spruill, Fazli Bozal, Annika De Jong, Alexandra Newman, Kamelia Drenkova, Michele Silvestro, Bhama Rhamkhelawon, Harmony Reynolds, Judith S Hochman, Matthias Nahrendorf, Filip K Swirski, Edward A A Fisher, Jeffrey S Berger, Kathryn J Moore
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
Psychological stress is associated with elevated circulating markers of inflammation, including inflammatory cytokines and acute phase reactants that accelerate progression of chronic inflammatory diseases (e.g., atherosclerosis, metabolic syndrome,
Autor:
Ann Marie Schmidt, Martin Schlegel, Alexandra A. C. Newman, Monika Sharma, Emma M Corr, Yannick Cyr, Coen van Solingen, Lianne C Shanley, Kathryn J. Moore, Milessa Silva Afonso, Emily J. Brown, Jonathan Guzman, Rubab Farhat, Graeme J. Koelwyn, Cyrus A Nikain, Edward A. Fisher, Daniel Peled
Publikováno v:
Circ Res
Rationale:Therapeutic efforts to decrease atherosclerotic cardiovascular disease risk have focused largely on reducing atherogenic lipoproteins, yet lipid-lowering therapies alone are insufficient to fully regress plaque burden. We postulate that art
Autor:
Naveed, Akbar, Adam T, Braithwaite, Emma M, Corr, Graeme J, Koelwyn, Coen, van Solingen, Clément, Cochain, Antoine-Emmanuel, Saliba, Alastair, Corbin, Daniela, Pezzolla, Malene, Møller Jørgensen, Rikke, Bæk, Laurienne, Edgar, Carla, De Villiers, Mala, Gunadasa-Rohling, Abhirup, Banerjee, Daan, Paget, Charlotte, Lee, Eleanor, Hogg, Adam, Costin, Raman, Dhaliwal, Errin, Johnson, Thomas, Krausgruber, Joey, Riepsaame, Genevieve E, Melling, Mayooran, Shanmuganathan, Christoph, Bock, David R F, Carter, Keith M, Channon, Paul R, Riley, Irina A, Udalova, Kathryn J, Moore, Daniel, Anthony, Robin P, Choudhury
Publikováno v:
Cardiovascular research.
Acute myocardial infarction rapidly increases blood neutrophils (2 hours). Release from bone marrow, in response to chemokine elevation, has been considered their source, but chemokine levels peak up to 24 hours after injury, and after neutrophil ele
Autor:
Edward A. Fisher, Martin Schlegel, Daniel Peled, Lauren Beckett, Alireza Khodadadi-Jamayran, Kathryn J. Moore, Lianne C Shanley, Huilin Li, Chiara Giannarelli, Coen van Solingen, Monika Sharma, Graeme J. Koelwyn, Karishma Rahman, Emily J. Brown, Milessa Silva Afonso
Publikováno v:
Circ Res
Rationale: MicroRNA-33 (miR-33 [post-transcriptionally in the rationale]) post-transcriptionally represses genes involved in lipid metabolism and energy homeostasis. Targeted inhibition of miR-33 increases plasma HDL (high-density lipoprotein) choles