Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Graeme J. Finlay"'
Publikováno v:
Molecules, Vol 26, Iss 3, p 552 (2021)
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acut
Externí odkaz:
https://doaj.org/article/3a345b1c41cb4573a9b93c642f5f8b07
Autor:
Euphemia Y. Leung, Marjan E. Askarian-Amiri, Dean C. Singleton, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Reuben J. Broom, Purvi M. Kakadia, Stefan K. Bohlander, Elaine Marshall, Bruce C. Baguley
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Most human breast cancer cell lines currently in use were developed and are cultured under ambient (21%) oxygen conditions. While this is convenient in practical terms, higher ambient oxygen could increase oxygen radical production, poten
Externí odkaz:
https://doaj.org/article/8fe0484eac0b4e098934e7c44d3dace8
Autor:
Euphemia Y. Leung, Marjan E. Askarian-Amiri, Debina Sarkar, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Bruce C. Baguley
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
IntroductionEndocrine therapy of breast cancer, which either deprives cancer tissue of estrogen or prevents estrogen pathway signaling, is the most common treatment after surgery and radiotherapy. We have previously shown for the estrogen-responsive
Externí odkaz:
https://doaj.org/article/c26f77e84ada42639446a2fb5d3822e5
Glioblastoma Multiforme is a highly aggressive brain malignancy commonly refractory to classical and novel chemo-, radio- and immuno-therapies, with median survival times of ~15 months following diagnosis. Poor immunological responses exemplified by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aac7448da845c7042d8ec71ac40bc6
Autor:
Akshata Anchan, Dan T Kho, Rebecca Johnson, Panagiota Kalogirou-Baldwin, Catherine E. Angel, James J W Hucklesby, Wayne R. Joseph, Simon J. O'Carroll, Graeme J. Finlay, E Scott Graham
Publikováno v:
Biosensors
Biosensors, Vol 9, Iss 2, p 56 (2019)
Volume 9
Issue 2
Biosensors, Vol 9, Iss 2, p 56 (2019)
Volume 9
Issue 2
Electric cell-substrate impedance sensing (ECIS) is an impedance-based method for monitoring changes in cell behaviour in real-time. In this paper, we highlight the importance of ECIS in measuring the kinetics of human melanoma cell invasion across h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cc76e3fe580e32fcd5ee61c6dd4d4e
https://pubmed.ncbi.nlm.nih.gov/30991758
https://pubmed.ncbi.nlm.nih.gov/30991758
Publikováno v:
Molecules, Vol 26, Iss 552, p 552 (2021)
Molecules
Molecules
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f19c3ae83fcf3259dc18a82470bfcb
https://doi.org/10.3390/molecules26030552
https://doi.org/10.3390/molecules26030552
Autor:
Laverne D Robilliard, Rebecca Johnson, Akshata Anchan, Graeme J. Finlay, James J W Hucklesby, Olivia Martin, Catherine E. Angel, Simon J. O'Carroll, E. Scott Graham
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8193, p 8193 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences
Volume 21
Issue 21
We have recently demonstrated that invasive melanoma cells are capable of disrupting the brain endothelial barrier integrity. This was shown using ECIS biosensor technology, which revealed rapid disruption via the paracellular junctions. In this pape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f38962fc666f1f2c780851207a35c5
https://doi.org/10.3390/ijms21218193
https://doi.org/10.3390/ijms21218193
Autor:
Debina, Sarkar, Ali, Oghabian, Pasani K, Bodiyabadu, Wayne R, Joseph, Euphemia Y, Leung, Graeme J, Finlay, Bruce C, Baguley, Marjan E, Askarian-Amiri
Publikováno v:
International Journal of Molecular Sciences
The long non-coding RNA ANRIL, antisense to the CDKN2B locus, is transcribed from a gene that encompasses multiple disease-associated polymorphisms. Despite the identification of multiple isoforms of ANRIL, expression of certain transcripts has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::747fb188fa78b515a2dfbfe2f4cdb200
https://pubmed.ncbi.nlm.nih.gov/28653984
https://pubmed.ncbi.nlm.nih.gov/28653984
Autor:
Marjan E. Askarian-Amiri, Euan J. Rodger, Graeme J. Finlay, Aniruddha Chatterjee, Bruce C. Baguley
Publikováno v:
Melanoma ISBN: 9783319783093
Melanoma is a highly heterogeneous malignancy that is the result of the accumulation of genetic and epigenetic defects. Genome and transcriptome analyses and extensive studies in DNA methylation, chromatin modifications and nucleosome positioning hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d70e60a5b0dd958aa35fd44e897a1f7
https://doi.org/10.1007/978-3-319-78310-9_7
https://doi.org/10.1007/978-3-319-78310-9_7
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(8)
1. Despite speculation that the CYP2C19 gene may contain CpG islands, there has been little direct assessment of the role for epigenetics in the regulation of this pharmacogene. The effect of 5-aza-2'-deoxycytidine (5azaDC), a DNA methyltransferase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be730999b4c6bb5280c463c939a67567
https://pubmed.ncbi.nlm.nih.gov/28840784
https://pubmed.ncbi.nlm.nih.gov/28840784