Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Graeme I Lancaster"'
Autor:
Dragana Dragoljevic, Man Kit Sam Lee, Gerard Pernes, Pooranee K Morgan, Cynthia Louis, Waled Shihata, Kevin Huynh, Arina A Kochetkova, Patrick W Bell, Natalie A Mellett, Peter J Meikle, Graeme I Lancaster, Michael J Kraakman, Prabhakara R Nagareddy, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 4, Pp n/a-n/a (2023)
Abstract Objectives The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine arthritis impairs atherosclerotic lesion regression, because of cellular cholesterol e
Externí odkaz:
https://doaj.org/article/48c0e47238314555b62510482001ecff
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 12, Pp n/a-n/a (2019)
Abstract The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and f
Externí odkaz:
https://doaj.org/article/cf5a4729a1a44c3c873361e473fecd1a
Autor:
Graeme I Lancaster, Michael J Kraakman, Helene L Kammoun, Katherine G Langley, Emma Estevez, Ashish Banerjee, Raelene J Grumont, Mark A Febbraio, Steve Gerondakis
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111524 (2014)
Alterations in the immune cell profile and the induction of inflammation within adipose tissue are a hallmark of obesity in mice and humans. Dual-specificity phosphatase 2 (DUSP2) is widely expressed within the immune system and plays a key role prom
Externí odkaz:
https://doaj.org/article/c6e9c3ba862d4d46b08bd8889f81e0b6
Autor:
Graeme I Lancaster, Greg M Kowalski, Emma Estevez, Michael J Kraakman, George Grigoriadis, Mark A Febbraio, Steve Gerondakis, Ashish Banerjee
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39100 (2012)
Obesity is associated with a state of chronic low grade inflammation that plays an important role in the development of insulin resistance. Tumor progression locus 2 (Tpl2) is a serine/threonine mitogen activated protein kinase kinase kinase (MAP3K)
Externí odkaz:
https://doaj.org/article/2e31a491233e4894a1717b561203ebd5
Autor:
Gerard Pernes, Pooranee K Morgan, Kevin Huynh, Corey Giles, Sudip Paul, Adam Alexander T Smith, Natalie A Mellett, Camilla Bertuzzo Veiga, Thomas JC Collins, T Michael De Silva, Man KS Lee, Peter J Meikle, Graeme I Lancaster, Andrew J Murphy
The cellular lipidome is comprised of thousands of unique lipid species. This complexity underpins the many roles of lipids in cellular biology. How lipidome composition varies between cell types and how such differences contribute to cell-specific f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655ad93c6f4343317ce82a95c9c91bfb
https://doi.org/10.1101/2023.02.10.528075
https://doi.org/10.1101/2023.02.10.528075
Autor:
Michael J. Kraakman, Helene L. Kammoun, Dragana Dragoljevic, Annas Al-Sharea, Man K.S. Lee, Michelle C. Flynn, Christian J. Stolz, Andrew A. Guirguis, Graeme I. Lancaster, Jaye Chin-Dusting, David J. Curtis, Andrew J. Murphy
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Obesity enhances the risk of developing myelodysplastic syndromes. However, the effect of obesity on survival is unclear. Obese people present with monocytosis due to inflammatory signals emanating from obese adipose tissue. We hypothesized that obes
Externí odkaz:
https://doaj.org/article/737696cb60b3401b9c2f8491dfff23ce
Autor:
Andrew J. Murphy, Darren C. Henstridge, Gerard Pernes, Kevin Huynh, Graeme I. Lancaster, Pooranee K. Morgan, Natalie A. Mellett, Peter J. Meikle
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 320:R95-R104
This study analyzed the effects of 24 h of cold stress (22°C or 5°C vs. mice maintained at 30 °C) on the plasma, brown adipose tissue (BAT), subcutaneous (SubQ) and epididymal (Epi) white adipose tissue (WAT), liver, and skeletal muscle lipidome o
Autor:
Graeme I. Lancaster, Denis Sviridov, Nigora Mukhamedova, Takahiro Kameda, Gerard Pernes, Peter J. Meikle, Ryunosuke Ohkawa, Boris L. Vaisman, Andrew J. Murphy, Ayuko Hara, Ying Fu, Michael Ditiatkovski, Shao-Jui Lai, Paul J. Nestel, Alan T. Remaley, Hann Low, Dmitri Sviridov, Minoru Tozuka, Yuna Horiuchi, Mai Sasaoka, Azusa Yamazaki
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1577-1588 (2020)
J Lipid Res
J Lipid Res
Lipoproteins play a key role in transport of cholesterol to and from tissues. Recent studies have also demonstrated that red blood cells (RBCs), which carry large quantities of free cholesterol in their membrane, play an important role in reverse cho
Autor:
Raelene Pickering, Man K.S. Lee, Kyle L. Hoehn, Graeme I. Lancaster, Josephine M. Forbes, Michelle C Flynn, Ira J. Goldberg, Fiona Hortle, Ellen M. Olzomer, Tessa J. Barrett, Dragana Dragoljevic, Assam El-Osta, Domenica A. McCarthy, Merlin C. Thomas, Andrew J. Murphy, Frances L. Byrne, Edward A. Fisher, Liza Makowski, Nordin M J Hanssen, Annas Al-Sharea, Casper G. Schalkwijk, Helene L. Kammoun, Michael J Kraakman, Prabhakara R Nagareddy, Christos Tikellis, Mark E. Cooper
Publikováno v:
Circulation Research, 127(7), 877-892. LIPPINCOTT WILLIAMS & WILKINS
Circ Res
Circulation research, 127(7), 877-892. Lippincott Williams and Wilkins
Circ Res
Circulation research, 127(7), 877-892. Lippincott Williams and Wilkins
Rationale: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time
Autor:
Adam Alexander T. Smith, Man K.S. Lee, Michelle Cinel, Bronwyn A. Kingwell, Sudip Paul, Paul J. Nestel, Kevin Culham, Natalie A. Mellett, Kaushala S. Jayawardana, Kevin A. Gunawan, Peter J. Meikle, Jacqueline M. Weir, Graeme I. Lancaster, Andrew J. Murphy
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100092-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100092-(2021)
Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oi