SR-141716A-induced stimulation of locomotor activity

Autor: Graeme Griffin, Anu Mahadevan, Raj K. Razdan, Mark C. Grier, Caroline E. Bass, Billy R. Martin

Publikováno v: Pharmacology Biochemistry and Behavior. 74:31-40

The central cannabinoid receptor (CB1) antagonist, SR-141716A, has been used extensively to ascertain that cannabinoids interact with the CB1 receptor. SR-141716A has been shown to produce effects opposite of cannabinoids when administered alone. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adde45f566ff6b205e70a9a6cc487cd3
https://doi.org/10.1016/s0091-3057(02)00945-0

A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid

Autor: Graeme Griffin, Ines Brandi, Mark C. Grier, William Williams, Raj K. Razdan, Sanjitha Kulasegram, Anu Mahadevan, Billy R. Martin, Vincenzo Di Marzo, Luciano De Petrocellis, Tiziana Bisogno

Publikováno v: The Journal of pharmacology and experimental therapeutics
300 (2002): 984–991. doi:10.1124/jpet.300.3.984
info:cnr-pdr/source/autori:Di Marzo V., Griffin G., De Petrocellis L., Brandi I., Bisogno T., Williams W., Grier M.C., Kulasegram S., Mahadevan A., Razdan R.K., Martin B.R./titolo:A structure%2Factivity relationship study on arvanil, an endocannabinoid and vanilloid hybrid/doi:10.1124%2Fjpet.300.3.984/rivista:The Journal of pharmacology and experimental therapeutics (Print)/anno:2002/pagina_da:984/pagina_a:991/intervallo_pagine:984–991/volume:300

Arvanil, a structural "hybrid" between the endogenous cannabinoid CB1 receptor ligand anandamide and capsaicin, is a potent agonist for the capsaicin receptor VR1 (vanilloid receptor type 1), inhibits the anandamide membrane transporter (AMT), and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb814cca8f7f938415822325365da4b2
https://doi.org/10.1124/jpet.300.3.984

Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain

Autor: Vincenzo Di Marzo, Graeme Griffin, Billy R. Martin, Christopher S. Breivogel

Publikováno v: Molecular Pharmacology. 60:155-163

The purpose of these studies was to support the hypothesis that an undiscovered cannabinoid receptor exists in brain. [(35)S]GTP gamma S binding was stimulated by anandamide and WIN55212-2 in brain membranes from both CB(1)(+/+) and CB(1)(-/-) mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58a27eef9ac57f99f0bd550b20cf91f6
https://doi.org/10.1124/mol.60.1.155

Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding

Autor: Bin Yang, Graeme Griffin, John W. Huffman, Mie Mie Aung, Vincent M. Showalter, Billy R. Martin, Mary E. Abood, Cheryl Keel, Ming-Jung Wu

Publikováno v: Drug and Alcohol Dependence. 60:133-140

The N-1 alkyl side chain of the aminoalkylindole analogues (AAI) has been implicated as one of a three-point interaction with the cannabinoid CB(1) receptor. In this study, the morpholinoethyl of WIN 55,212-2 was replaced with carbon chains of varyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2748ac72ee192559b57e1a5dd3c8d90d
https://doi.org/10.1016/s0376-8716(99)00152-0

An investigation into the structural determinants of cannabinoid receptor ligand efficacy

Autor: Emma J Wray, Mary E. Abood, Raj K. Razdan, William K Rorrer, William R. Ryan, Peter J Crocker, Bijali Saha, Billy R. Martin, Graeme Griffin

Publikováno v: British Journal of Pharmacology. 126:1575-1584

1. A number of side-chain analogues of delta8-THC were tested in GTPgammaS binding assay in rat cerebellar membranes. O-1125, a saturated side-chain compound stimulated GTPgammaS binding with an Emax of 165.0%, and an EC50 of 17.4 nM. 2. O-1236, O-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::310b06ea72dea28a3fa1aef880263d3b
https://doi.org/10.1038/sj.bjp.0702469