Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Graeme Fraser"'
Autor:
Amr H. Saleh, Michael Rothe, Dwayne L. Barber, William M. McKillop, Graeme Fraser, Chantal F. Morel, Axel Schambach, Christiane Auray-Blais, Michael L. West, Aneal Khan, Daniel H. Fowler, C. Anthony Rupar, Ronan Foley, Jeffrey A. Medin, Armand Keating
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 262-271 (2023)
The safety and efficacy of lentivirus-mediated gene therapy was recently demonstrated in five male patients with Fabry disease—a rare X-linked lysosomal storage disorder caused by GLA gene mutations that result in multiple end-organ complications.
Externí odkaz:
https://doaj.org/article/94ca546755434fd5983165124cd0e623
Autor:
Aneal Khan, Dwayne L. Barber, Ju Huang, C. Anthony Rupar, Jack W. Rip, Christiane Auray-Blais, Michel Boutin, Pamela O’Hoski, Kristy Gargulak, William M. McKillop, Graeme Fraser, Syed Wasim, Kaye LeMoine, Shelly Jelinski, Ahsan Chaudhry, Nicole Prokopishyn, Chantal F. Morel, Stephen Couban, Peter R. Duggan, Daniel H. Fowler, Armand Keating, Michael L. West, Ronan Foley, Jeffrey A. Medin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Treatments for Fabry disease, an inherited lysosomal disorder caused by the deficiency of the enzyme alpha-galactosidase A, are not fully efficacious. Here the authors report a single-arm phase I trial of gene therapy with autologous, lentivirus-tran
Externí odkaz:
https://doaj.org/article/e1df374ec9104eca99e1b0892655fcfa
Publikováno v:
Blood Advances, Vol 1, Iss 12, Pp 772-778 (2017)
Abstract: Ibrutinib therapy was associated with an increased risk of bleeding in previous trials. In this systematic review and meta-analysis of published trials including patients treated with ibrutinib, the relative risk (95% confidence interval [C
Externí odkaz:
https://doaj.org/article/54ca45fc0d64401abfbddad7e8083990
Autor:
Jennifer R. Brown, Javid Moslehi, Susan O’Brien, Paolo Ghia, Peter Hillmen, Florence Cymbalista, Tait D. Shanafelt, Graeme Fraser, Simon Rule, Thomas J. Kipps, Steven Coutre, Marie-Sarah Dilhuydy, Paula Cramer, Alessandra Tedeschi, Ulrich Jaeger, Martin Dreyling, John C. Byrd, Angela Howes, Michael Todd, Jessica Vermeulen, Danelle F. James, Fong Clow, Lori Styles, Rudy Valentino, Mark Wildgust, Michelle Mahler, Jan A. Burger
Publikováno v:
Haematologica, Vol 102, Iss 10 (2017)
The first-in-class Bruton’s tyrosine kinase inhibitor ibrutinib has proven clinical benefit in B-cell malignancies; however, atrial fibrillation (AF) has been reported in 6–16% of ibrutinib patients. We pooled data from 1505 chronic lymphocytic l
Externí odkaz:
https://doaj.org/article/f2985c5022894b3aa2128bf6561c3340
Autor:
Amaris Balitsky, Greg Pond, Gwynivere Davies, Graeme Fraser, Tom Kouroukis, Mark Levine, Ralph Meyer, Ronan Foley
Purpose Chimeric antigen receptor T-cell (CART) therapy has shown clinical efficacy in refractory and relapsed large B-cell lymphomas, but is associated with serious acute and long-term toxicities. To understand the patient perspective, we measured a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80454d07473cf8cc05e7cf73b01e0a51
https://doi.org/10.21203/rs.3.rs-2907146/v1
https://doi.org/10.21203/rs.3.rs-2907146/v1
Autor:
Jean Combalbert, Dirk Timmerman, Bart C.J.M. Fauser, Joop S.E. Laven, Graeme Fraser, Hamid R. Hoveyda, Axelle Pintiaux, Barbara Obermayer-Pietsch, Steven Ramael, Georg Griesinger, Christopher Lademacher
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 106(9), E3519-E3532. Endocrine Society
Context Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized by hyperandrogenism, is the leading cause of anovulatory infertility. Objective This proof-of-concept study evaluated clinical efficacy and safety of the ne
Publikováno v:
Blood. 140:8036-8037
Publikováno v:
Journal of geriatric oncology. 13(8)
As the Canadian population ages, older adults comprise an increasing proportion of those diagnosed and treated for hematologic malignancies. A geriatric oncology curriculum has been recognized as a top priority in the care of older patients with canc
Autor:
Graeme Fraser, Catherine Sorlet, Nicolas Parmentier, Elodie Brunel, Anne-France Hartiel, Killian Oukoloff, Guillaume Dutheuil
Publikováno v:
Cancer Research. 83:6282-6282
METTL3 is the RNA methyltransferase predominantly responsible for the addition of N-6-methyladenosine (m6A), the most abundant modification to mRNA. The prevalence of m6A and the activity and expression of METTL3 have been linked to the appearance an
Autor:
Christopher Bredeson, Graeme Fraser, Michael Crump, Andrew Aw, Matthew C. Cheung, S. Bhella, Norma P. Varela, S. Sajkowski, Tom Kouroukis
Publikováno v:
Curr Oncol
Current Oncology
Volume 27
Issue 6
Pages 7053-644
Current Oncology
Volume 27
Issue 6
Pages 7053-644
Background: In Ontario, no clearly defined standard of care for the management of mantle cell lymphoma (mcl) has been developed, and substantial variability from centre to centre is evident. This guidance document was prompted by the need to harmoniz