Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde

Autor: Varinder K. Aggarwal, Graeme Coulthard, Steven H. Bennett

Publikováno v: Bennett, S H, Coulthard, G & Aggarwal, V K 2020, ' Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde ', Chemical Record . https://doi.org/10.1002/tcr.202000054

Prostaglandins have been attractive targets in total synthesis for over 50 years, resulting in the development of new synthetic strategies and methodologies that have served the broader chemical community. However, these molecules are not just of aca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5618c5f1b90c3aec47cf204afb9dbb
https://hdl.handle.net/1983/227d0a3b-8544-458c-9791-a6a59a63e6cf

Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling

Autor: John A. Murphy, Matthew P. John, Joshua P. Barham, Nathan Delgado, Graeme Coulthard, Ryan G. Kane

Publikováno v: Angewandte Chemie International Edition. 55:4492-4496

Transition metal-free couplings of haloarenes with arenes, triggered by the use of alkali metal alkoxides in the presence of an organic additive, are receiving significant attention in the literature. Most of the known organic additives effect coupli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d044b8b103517c37fe41bf10493e713
https://doi.org/10.1002/anie.201511847

Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene

Autor: John A. Murphy, Samuel S. Hanson, C. Adam Dyker, Kyle T. Traboulsee, Eswararao Doni, Graeme Coulthard

Publikováno v: Angewandte Chemie (International Ed. in English)

A new ground-state organic electron donor has been prepared that features four strongly π-donating iminophosphorano substituents on a bispyridinylidene skeleton. Cyclic voltammetry reveals a record redox potential of −1.70 V vs. saturated calomel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe054f72d586ca2574672136beed390
https://doi.org/10.1002/anie.201505378

Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine

Autor: Christiana Kitsiou, Richard J. K. Taylor, Graeme Coulthard, William P. Unsworth

Publikováno v: Tetrahedron. 70:7172-7180

The direct imine acylation (DIA) and subsequent cyclisation of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined. The DIA procedure was also ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57110e14d7cd2a690592586967c58c17
https://doi.org/10.1016/j.tet.2014.04.066

KOtBu : a privileged reagent for electron transfer reactions?

Autor: Leonard Berlouis, Florimond Cumine, Joshua P. Barham, Eswararao Doni, Graeme Coulthard, Giuseppe Nocera, Katie J. Emery, Tell Tuttle, Matthew P. John, Thomas M. McGuire, John A. Murphy

Many recent studies have used KOtBu in organic reactions that involve single electron transfer; in the literature, the electron transfer is proposed to occur either directly from the metal alkoxide or indirectly, following reaction of the alkoxide wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e9f005a845e7eb21ed5790aa2e0f97
https://strathprints.strath.ac.uk/56422/8/Barham_etal_JACS_2016_KOtBu_a_privileged_reagent_for_electron_transfer.pdf