Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Graeme C. Freestone"'
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Hans Gaus, Michael T. Migawa, Eric. E. Swayze, Thomas E. Cheatham, Punit P. Seth, Stephen Hanessian
Publikováno v:
The Journal of Organic Chemistry. 88:3599-3614
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico, Juan C. Salinas, Hans Gaus, Michael T. Migawa, Eric E. Swayze, Thomas E. Cheatham, Stephen Hanessian, Punit P. Seth
Publikováno v:
J Am Chem Soc
Journal of the American Chemical Society, vol 144, iss 4
Journal of the American Chemical Society, vol 144, iss 4
The binding affinity of therapeutic oligonucleotides (ONs) for their cognate RNA is determined by the rates of association (ka) and dissociation (kd). Single-stranded ONs are highly flexible and can adopt multiple conformations in solution, some of w
Autor:
Xue-hai Liang, Cheryl L De Hoyos, Punit P. Seth, Stanley T. Crooke, Graeme C Freestone, Michael E Ǿstergaard, Audrey Low, Guillermo Vasquez, Jinghua Yu, Eric E. Swayze, Michael T. Migawa, W. Brad Wan, Thazha P. Prakash
Publikováno v:
Nucleic Acids Research
We recently showed that site-specific incorporation of 2′-modifications or neutral linkages in the oligo-deoxynucleotide gap region of toxic phosphorothioate (PS) gapmer ASOs can enhance therapeutic index and safety. In this manuscript, we determin
Publikováno v:
Angewandte Chemie International Edition. 45:5364-5368
Publikováno v:
Angewandte Chemie. 118:5490-5494
Autor:
Caroline L Rigby, Rick P. C. Cousins, Gurdip Bhalay, Timothy J. Donohoe, Catherine E. Headley, Graeme C. Freestone
Publikováno v:
Organic Letters. 6:3055-3058
[reaction: see text] The partial reduction of 2,5-pyrrole diester 1 followed by enantioselective protonation in situ to furnish synthetically useful building blocks is described. An enantiomeric excess of up to 74% was achieved using (-)-ephedrine an
Autor:
Anthony Estrada, Sang Hyup Lee, Kyriacos C. Nicolaou, Xavier Alvarez-Mico, Graeme C. Freestone
Publikováno v:
Tetrahedron. 63(27)
A new synthetic method providing expedient access to a wide range of polyfunctionalized N-hydroxyindoles (IV) is reported. These unique constructs are assembled by nucleophilic additions to in situ generated α,β-unsaturated nitrones (III) through c
Autor:
Xavier Alvarez-Mico, Kyriacos C. Nicolaou, Graeme C. Freestone, Anthony Estrada, Sang Hyup Lee
Publikováno v:
ChemInform. 38
A new synthetic method providing expedient access to a wide range of polyfunctionalized N-hydroxyindoles (IV) is reported. These unique constructs are assembled by nucleophilic additions to in situ generated α,β-unsaturated nitrones (III) through c
Publikováno v:
ChemInform. 37
Autor:
Timothy J. Donohoe, Ali Raoof, Ian D. Linney, Graeme C. Freestone, Andrew R. Cowley, Madeleine Helliwell
Publikováno v:
Organic letters. 4(18)
[reaction: see text] The stereoselective Birch reduction of 3-methyl-2-furoic acids using a readily available chiral auxilairy is described; by coupling this process to an oxidative cleavage/aldol ring closure sequence we were able to produce highly