Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Graeme C Smith"'
Autor:
Danny A Bitton, Falk eSchubert, Shoumit eDey, Michal eOkoniewski, Graeme C Smith, Sanjay eKhadayate, Vera ePancaldi, Valerie eWood, Jurg eBahler
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
Genome-wide assays and screens typically result in large lists of genes or proteins. Enrichments of functional or other biological properties within such lists can provide valuable insights and testable hypotheses. To systematically detect these enri
Externí odkaz:
https://doaj.org/article/aabdd0679a234a84b562949d1ff796fa
Autor:
Graeme C Smith
Publikováno v:
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists.
Aims and objectivesTo explore the value of using Karl Jaspers’ lived experience concept of ‘grasping’ in remediating the reported dauntingness of formulation.ConclusionsFormulation can be construed as both the process and explication of underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf210ac43e66760dd4091812782bd076
https://pubmed.ncbi.nlm.nih.gov/36415949
https://pubmed.ncbi.nlm.nih.gov/36415949
Autor:
Graeme C. Smith
Publikováno v:
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists. 30(2)
Objective:To explore the theme identified by Bagster et al.1in their selective psychiatric literature review that formulation can appear daunting.Conclusion:Formulation is understandably daunting, even though it occurs in all human encounters. The pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57ea2808c9a209daaac142d76186a47
https://pubmed.ncbi.nlm.nih.gov/34748710
https://pubmed.ncbi.nlm.nih.gov/34748710
Autor:
Diana Zatreanu, Helen Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luted Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Andre Nussenzweig, Marcel Tijsterman, Andrew N. Tutt, Simon Boulton, Geoff Higgins, Stephen J. Pettitt, Graeme C. Smith, Christopher J. Lord
Publikováno v:
Cancer Research. 82:5697-5697
To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits the major Polθ-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0d9d73e0b3ce9af06ce913425ebd3e
https://doi.org/10.1158/1538-7445.am2022-5697
https://doi.org/10.1158/1538-7445.am2022-5697
Autor:
Ke Cong, Jiri Bartek, Graeme C. Smith, Sharon B. Cantor, Jinhyuk Bhin, Marieke van de Ven, Miguel Andújar-Sánchez, Mariana Paes Dias, Vivek Tripathi, Stefano Annunziato, Eleni Maria Manolika, Cor Lieftink, Roderick L. Beijersbergen, Jos Jonkers, Ingrid van der Heijden, Jirina Bartkova, Arnab Ray Chaudhuri, Sanjiban Chakrabarty, Sven Rottenberg, Ewa Gogola, Panagiotis Galanos
Publikováno v:
Mol Cell
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
SUMMARYInhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, preclinical and clinical research with PARPi has reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438d569285ad1b511368f34691daf54c
https://pubmed.ncbi.nlm.nih.gov/34555355
https://pubmed.ncbi.nlm.nih.gov/34555355
Autor:
Graeme C. Smith
Publikováno v:
Psychiatry Reborn: Biopsychosocial psychiatry in modern medicine
‘Formulation in the face of complexity’ examines complexity theory’s contribution to the task of formulating an answer to the holistic question, ‘Why is this person presenting in this way at this time?’, a question for which diagnostic labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f8735d3e31edbeb18a1e02456e1644b
https://doi.org/10.1093/med/9780198789697.003.0009
https://doi.org/10.1093/med/9780198789697.003.0009
Autor:
Eric T. Dawson, Chunlin Xiao, Noah Alexander, Sree Rohit Raj Kolora, Lesley M. Chapman, Aaron M. Wenger, Christopher M. Watson, Giuseppe Narzisi, Justin M. Zook, Daniel Blankenberg, Christian Brueffer, Graeme C. Smith, Marc L. Salit, Azza Ahmed, Paul Wolujewicz, Saadlee Shehreen, Naoki Nariai, Patrick Pai, Christos Proukakis, Andrew Carroll, Garan Jones, Wayne E. Clarke, Noah Spies, Chun Shen Lim
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007933 (2020)
PLoS Computational Biology
PLoS Computational Biology
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is more c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b519ca4c264c97671517aa93577cb7d9
Autor:
Christos Proukakis, Andrew Carroll, Sree Rohit Raj Kolora, Graeme C. Smith, Daniel Blankenberg, Chunlin Xiao, Garan Jones, Aaron M. Wenger, Christian Brueffer, Noah Alexander, Lesley M. Chapman, Noah Spies, Azza Ahmed, Naoki Nariai, Saadlee Shehreen, Christopher M. Watson, Justin M. Zook, Giuseppe Narzisi, Marc L. Salit, Paul Wolujewicz, Chun Shen Lim, Wayne E. Clarke, Patrick Pai, Eric T. Dawson
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is yet to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea977398bdfe2d49717f7cdc65d4c57f
Autor:
Graeme C. Smith
Publikováno v:
Musicology Australia. 37:218-233
Australian folk song and music have been created as unified genres by activists, enthusiasts and performers. Various commentators have discussed ways in which the genre is the product of unacknowledged selectiveness, conflations and exclusions of his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfcbe989a7907d7b3fecc6795cdbb55
https://doi.org/10.1080/08145857.2015.1065549
https://doi.org/10.1080/08145857.2015.1065549
Autor:
Graeme C. Smith
Publikováno v:
Australasian Psychiatry. 22:28-31
Objective: The purpose of this paper is to review the theoretical basis of addressing the concept of the unique individual, one of the tasks prescribed in the Royal Australian and New Zealand College of Psychiatrists (RANZCP) Formulation guidelines f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875323c6eccb005a111370963e2a4c29
https://doi.org/10.1177/1039856213511672
https://doi.org/10.1177/1039856213511672