Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Graeme C M Smith"'
Autor:
Fadhel S Shaheen, Pawel Znojek, Ann Fisher, Martin Webster, Ruth Plummer, Luke Gaughan, Graeme C M Smith, Hing Y Leung, Nicola J Curtin, Craig N Robson
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20311 (2011)
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease escapes the hormone dependent stage to a more aggressive status where chemotherapy is the only effective treatment and no trea
Externí odkaz:
https://doaj.org/article/d6fef4626adc41e5a9e44a0fe038bde9
Autor:
Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, en
Externí odkaz:
https://doaj.org/article/a5462d8522964b13a5f79a9e1b35250a
Autor:
Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M. Boyd, Mat Calder, Mark D. Charles, Lucy V. Edwardes, Tennyson Ekwuru, Harry Finch, Alessandro Galbiati, Lerin Geo, Diego Grande, Vera Grinkevich, Nicholas D. Holliday, Wojciech W. Krajewski, Ellen MacDonald, Jayesh B. Majithiya, Hollie McCarron, Claire L. McWhirter, Viral Patel, Chris Pedder, Eeson Rajendra, Marco Ranzani, Laurent J. M. Rigoreau, Helen M. R. Robinson, Theresia Schaedler, Julija Sirina, Graeme C. M. Smith, Martin E. Swarbrick, Andrew P. Turnbull, Simon Willis, Robert A. Heald
Publikováno v:
Journal of Medicinal Chemistry. 65:13879-13891
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other DNA repair pathway defective cancers. As previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3234589eaa7f5350d23a2af196b12e
https://doi.org/10.1021/acs.jmedchem.2c01142
https://doi.org/10.1021/acs.jmedchem.2c01142
Autor:
Graeme C. M. Smith, Andy Cui, A. Hughes, Stephanie Ling, Lucy Riches, Barlaam Bernard Christophe, Aaron Smith, Martin Pass, Gareth Hughes, Gemma N Jones, Kurt Gordon Pike, Andrew G. Thomason, Mark J. O'Connor, Elaine Cadogan, Antonio García Trinidad, Paul R. Gavine, Pendeep Gill, Louise Goodwin, Jonathan Stott, Roger Clark, Samantha Peel
Publikováno v:
Molecular Cancer Therapeutics. 19:13-25
AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated (ATM) protein, a signaling kinase involved in the DNA damage response. We present preclinical data demonstrating abrogation of irradiation-induced ATM signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8013d2c1937888f6856e46b24dac6c3d
https://doi.org/10.1158/1535-7163.mct-18-1394
https://doi.org/10.1158/1535-7163.mct-18-1394
Autor:
Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
Publikováno v:
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877
https://hdl.handle.net/1887/3213877
Autor:
Diana A. Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Steve Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publikováno v:
Molecular Cancer Therapeutics. 20:P056-P056
To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight, allosteric inhibitors of the polymerase function of DNA polymerase Theta (Polθ), including ART558. ART558 inhibits the major Polθ-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73bac7eb464761e2d542bd7b0cb26fd
https://doi.org/10.1158/1535-7163.targ-21-p056
https://doi.org/10.1158/1535-7163.targ-21-p056
Autor:
G. Tim Burstein, Graeme C. M. Smith, Dominik Eder, Karl Schulte, Thea I. W. Schnoor, Alan H. Windle, Krzysztof K. K. Koziol
Publikováno v:
Carbon. 60:229-235
We synthesized highly porous composite films of vertically aligned carbon nanotubes (CNTs) and polypyrrole (PPy) by employing a simple in situ electropolymerisation process from aqueous pyrrole solutions. By contacting the entire CNT array, each CNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9e108c39cb328d09a7842328fc09ce4
https://doi.org/10.1016/j.carbon.2013.04.016
https://doi.org/10.1016/j.carbon.2013.04.016
Autor:
Celine Cano, Pia Thommes, Niall M. B. Martin, Yan Zhao, Liam Cornell, Michael A. Batey, Helen Jenkins, Jody Barbeau, Keith Allan Menear, Julia Bardos, Nicola J. Curtin, Michele Tavecchio, David R. Newell, Roger J. Griffin, Caroline Richardson, Graeme C. M. Smith, Andrew Slade, Joanne M. Munck
Publikováno v:
Molecular Cancer Therapeutics. 11:1789-1798
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79970d5d09b4bd6b730644af5e24957f
https://doi.org/10.1158/1535-7163.mct-11-0535
https://doi.org/10.1158/1535-7163.mct-11-0535
Autor:
Anna Skowronska, Zbigniew Rudzki, Guy Pratt, Graeme C. M. Smith, Martin J. S. Dyer, Pamela Kearns, Victoria J Weston, A. Malcolm R. Taylor, Ceri E. Oldreive, Paul Moss, Tatjana Stankovic, J. E. Powell, David Oscier
Publikováno v:
Blood. 116:4578-4587
The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid malignancies such as chronic lymphocytic leukemia (CLL), T-prolymphocytic leukemia (T-PLL), and mantle cell lymphoma (MCL) and is associated with defective apoptosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaecd811c3d370451e131e511939cfd
https://doi.org/10.1182/blood-2010-01-265769
https://doi.org/10.1182/blood-2010-01-265769
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 75:1520-1527
Purpose Radiation-induced DNA double strand breaks (DSBs) are predominantly repaired by nonhomologous end joining (NHEJ), involving DNA-dependent protein kinase (DNA-PK). Poly(ADP-ribose) polymerase-1 (PARP-1), well characterized for its role in sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23d077d7440a365e844d29a5c104d80
https://doi.org/10.1016/j.ijrobp.2009.07.1722
https://doi.org/10.1016/j.ijrobp.2009.07.1722