Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Graeme Bainbridge"'
Autor:
Sham Nambulli, Linda J. Rennick, Andrew S. Acciardo, Natasha L. Tilston-Lunel, Gregory Ho, Nicholas A. Crossland, Kathy Hardcastle, Betsy Nieto, Graeme Bainbridge, Tracey Williams, Claire R. Sharp, W. Paul Duprex
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
Feline morbillivirus (FeMV) is a recently discovered pathogen of domestic cats and has been classified as a morbillivirus in the Paramyxovirus family. We determined the complete sequence of FeMV US5 directly from an FeMV-positive urine sample without
Autor:
Tom Wilson, Gary F. Bammert, Steven A. Dunham, Sebastian C.J. Steiniger, Abhiram Krishnan, Graeme Bainbridge, William Dunkle, Gregory C. Ippolito
Publikováno v:
Molecular Immunology. 59:71-78
Complementarity determining regions (CDR) are responsible for binding antigen and provide substantial diversity to the antibody repertoire, with VH CDR3 of the immunoglobulin variable heavy (VH) domain playing a dominant role. In this study, we exami
Autor:
Leszek J. Choromanski, Catherine J. Strietzel, Graeme Bainbridge, Lisa M. Bergeron, Veronica T. Mutchler, Theodore Oliphant
Publikováno v:
Veterinary Immunology and Immunopathology. 158:214-223
Very little is known about the functional properties of feline IgGs. Here we report the in vitro characterization of cloned feline IgGs. Rapid amplification of cDNA ends (RACE) and full-length PCR of cat splenic cDNA were used to identify feline sequ
Autor:
Nicole Caspers, James B. Dunbar, Alexander Pavlovsky, Robert M. Kennedy, Graeme Bainbridge, Elizabeth Bills, Melissa S. Harris, Gary Louis Bolton, Richard H. Hutchings, Larry D. Bratton, Jeffrey A. Pfefferkorn, Ronald W. Sarver, Scott D. Larsen
Publikováno v:
Journal of Medicinal Chemistry. 51:3804-3813
Clinical studies have demonstrated that statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitors, are effective at lowering mortality levels associated with cardiovascular disease; however, 2-7% of patients may experience statin-ind
Autor:
Graeme Bainbridge, Nicole Caspers, Andrew Robertson, Jeffrey A. Pfefferkorn, Yuntao Song, Lisa Dillon, Catherine Sekerke, Jeffrey C. Hanselman, Chulho Choi, Gina Lu, Valerie Askew, Zhiwu Lin, Alexander Pavlovsky, Bharat K. Trivedi, Bruce Auerbach, Scott D. Larsen, Melissa S. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4531-4537
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models an
Autor:
Yuntao Song, Jeffrey C. Hanselman, Xue-Min Cheng, Scott D. Larsen, Zhiwu Lin, Bharat K. Trivedi, Graeme Bainbridge, Alexander Pavlovsky, Larry D. Bratton, Andrew Robertson, Paul C. Unangst, Jeffrey A. Pfefferkorn, Melissa S. Harris, Lisa Dillon, Bruce Auerbach, Erasga Noe Ouano, Chitase Lee, Chulho Choi, Karl Olsen, Catherine Sekerke, Toni Jo Poel, Nicole Caspers, Matthias Eberstadt, Kuai Lin Sun, Steven R. Miller, Roderick Joseph Sorenson, Gina Lu, Valerie Askew, Thomas E. Mertz, Huifen Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4538-4544
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations result
Autor:
Jeremy H. Lakey, Lynn G. Dover, Graeme Bainbridge, Elaine M. Raggett, Susan L. Fridd, Lucy J. A. Evans
Publikováno v:
Biochemistry. 39:8632-8637
Colicin N kills sensitive Escherichia coli cells by first binding to its trimeric receptor (OmpF) via its receptor binding domain. It then uses OmpF to translocate across the outer membrane and in the process it also needs domains II and III of the p
Publikováno v:
FEBS Letters. 432:117-122
The pore-forming colicins N and A require the porin, OmpF, in order to translocate across the outer membrane of Escherichia coli. We investigated the hypothesis that in vivo, colicins N and A may traverse the outer membrane through the OmpF channel.
Publikováno v:
FEBS Letters. 431:305-308
Beta-barrel pores are found in outer membrane porins of Gram-negative bacteria, bacterial toxins and mitochondrial channels. Apart from the β-barrel the three groups show no close sequence or structural homology but these pores exhibit symmetrical v
Publikováno v:
Journal of Molecular Biology. 275:171-176
Porins, such as Escherichia coli OmpF, provide the only reported example of a voltage-gated channel where the three-dimensional structure is known to high resolution. Mutations that affect voltage-gating are clustered around the eyelet region, which