Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Graeme B. Scarfe"'
Autor:
Graeme B. Scarfe, Ian D. Wilson, Jeremy K. Nicholson, Jose Castro-Perez, John C. Lindon, F. R. Abou-Shakra, A. B. Sage
Publikováno v:
Chromatographia. 55:S9-S13
The use of reversed-phase gradient HPLC coupled to UV, ICPMS and oa-TOFMS for the profiling and identification of metabolites in rat urine following the administration 4-bromoaniline is described. Following chromatographic separation and UV detection
Autor:
Fadi Abou-Shakra, John C. Lindon, Jose Castro-Perez, Ashley Sage, Ian D. Wilson, Graeme B. Scarfe, Jeremy K. Nicholson
Publikováno v:
Analytical Chemistry. 73:1491-1494
The use of HPLC coupled to inductively coupled plasma mass spectrometry (ICPMS) and orthogonal acceleration time-of-flight (oa-TOF) for the profiling, identification, and quantification of metabolites in rat urine following the administration of 2-br
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 748:311-319
The urinary excretion profile and identity of the metabolites of 2,3,5,6-tetrafluoro-4-triflouromethylaniline, following i.p. administration to the rat at 50 mg kg −1 , were determined using a combination of 19 F-NMR, HPLC–NMR and HPLC–MS. A to
Autor:
John C. Lindon, Stephen D. Taylor, Graeme B. Scarfe, Jeremy K. Nicholson, B. Wright, Clayton Edward, Ian D. Wilson
Publikováno v:
Xenobiotica. 29:77-91
1. The metabolism and urinary excretion of 2-chloro-4-trifluoromethylaniline has been studied in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS methods. The compound was dosed to three male Sprague-Dawley rats (50 mg kg(-1) i.p.)
Publikováno v:
Xenobiotica. 29:205-216
1. The urinary metabolic fate of 4-fluoroaniline (4-FA) and 1-[13C]-4-fluoroacetanilide (4-FAA) has been studied using NMR-based methods after 50 and 100 mg kg(-1) i.p. doses respectively to the male Sprague-Dawley rat. 2. 4-FA was both ortho- and pa
Autor:
Klaus Pusecker, Jens Schewitz, Petra Gfrörer, Li-Hong Tseng, Klaus Albert, Ernst Bayer, Ian D. Wilson, Nigel J. Bailey, Graeme B. Scarfe, Jeremy K. Nicholson, John C. Lindon
Publikováno v:
Analytical Communications. 35:213-215
Direct NMR spectroscopic detection on-flow to capillary electrophoresis (CE) or capillary electrochromatography (CEC) was applied to the separation of metabolites of paracetamol from an extract of human urine. The detection and characterisation of th
Autor:
Graeme B. Scarfe, Jeremy K. Nicholson, Ian D. Wilson, John C. Lindon, Manfred Spraul, Ulrich Braumann, Martin Hofmann
Publikováno v:
Analytical Communications. 34:37-39
Directly coupled HPLC–NMR–MS was used to identify the major urinary metabolite of 2-bromo-4-trifluoromethylaniline in the rat as the sulfate conjugate of 2-bromo-4-trifluoromethyl-6-hydroxyaniline. This metabolite could not have been fully charac
Autor:
Graeme B. Scarfe, Patrick Maurel, Lydiane Pichard-Garcia, Jean-Michel Fabre, Richard J. Weaver, Catherine Lucas, Nina Eckett
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(1)
The olivacine derivative 9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-b)-carbazole-1-carboxamide (S 16020) exhibits a potent antitumor activity. However, when administered in cancer patients, its blood clearance increases after rep
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 32(4)
1. The relationship between the in vivo metabolism of substituted anilines, in particular N-acetylation and subsequent formation of oxanilic acids, and their molecular physico-chemical properties has been investigated using computational chemistry an
Autor:
Brian Wright, Ian D. Wilson, Stephen D. Taylor, J. K. Nicholson, John C. Lindon, Clayton Edward, Graeme B. Scarfe
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 32(4)
1. The urinary excretion of 4-bromoaniline and its [carbonyl-(13)C]-labelled N-acetanilide, together with their corresponding metabolites, have been investigated in the rat following i.p. administration at 50 mg kg(-1). 2. Metabolite profiling was pe