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pro vyhledávání: '"Graeme B. Bolger"'
Autor:
Graeme B. Bolger
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17363 (2023)
The development of a wider range of therapeutic options is a key objective in drug discovery for chronic obstructive pulmonary disease (COPD). Fundamental advances in lung biology have the potential to greatly expand the number of therapeutic targets
Externí odkaz:
https://doaj.org/article/30bbbe6120e5478c8fc5b1ef123e6417
Autor:
Graeme B. Bolger
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range of cell origins, clinical manifestations, and potential therapeutic opt
Externí odkaz:
https://doaj.org/article/c77f72a598634fafa2b1eb099502a28c
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-20 (2017)
Abstract Background PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other function
Externí odkaz:
https://doaj.org/article/cc4c65e396c04c169a96cf0d02d4e567
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1–11), expressed in different tissues and cells, including heart and brain. The isoforms PDE4, PDE7, and PDE8
Externí odkaz:
https://doaj.org/article/4dce049817d740128fdabd6c775b31b6
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5704 (2020)
PDE4 cyclic nucleotide phosphodiesterases reduce 3′, 5′ cAMP levels in the CNS and thereby regulate PKA activity and the phosphorylation of CREB, fundamental to depression, cognition, and learning and memory. The PDE4 isoform PDE4D5 interacts wit
Externí odkaz:
https://doaj.org/article/4e1dbd705c624c59b900f1618214b9d5
Autor:
Graeme B. Bolger
Publikováno v:
Trends in Genetics. 37:669-681
The phosphodiesterase (PDE)-opathies, an expanding set of disorders caused by germline mutations in cyclic nucleotide PDEs, present an intriguing paradox. The enzymes encoded by the PDE family all hydrolyze cAMP and/or cGMP, but mutations in differen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5704, p 5704 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences
Volume 21
Issue 16
PDE4 cyclic nucleotide phosphodiesterases reduce 3&prime
5&prime
cAMP levels in the CNS and thereby regulate PKA activity and the phosphorylation of CREB, fundamental to depression, cognition, and learning and memory. The PDE4 isoform PDE4D
5&prime
cAMP levels in the CNS and thereby regulate PKA activity and the phosphorylation of CREB, fundamental to depression, cognition, and learning and memory. The PDE4 isoform PDE4D
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-20 (2017)
BMC Neuroscience
BMC Neuroscience
Background: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The P
Autor:
Graeme B. Bolger
Publikováno v:
Cellular Signalling. 35:256-263
The RACK1 protein interacts with numerous proteins involved in signal transduction, the cytoskeleton, and mRNA splicing and translation. We used the 2-hybrid system to identify additional proteins interacting with RACK1 and isolated the RNA-binding p
Autor:
Graeme B. Bolger
Publikováno v:
Cellular Signalling. 28:706-712
PDE4 family cAMP-selective cyclic nucleotide phosphodiesterases are important in the regulation of cAMP abundance in numerous systems, and thereby play an important role in the regulation of PKA and EPAC activity and the phosphorylation of CREB. We h