Zobrazeno 1 - 10
of 614
pro vyhledávání: '"Graeme, Milligan"'
Autor:
Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S. Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L. Carlson, Samantha T. Reyes, Isaac M. Jackson, Lorenzo Suigo, Audrey Luo, Sydney C. Nagy, Ermanno Valoti, Graeme Milligan, Frezghi Habte, Bin Shen, Michelle L. James
Publikováno v:
JACS Au, Vol 3, Iss 12, Pp 3297-3310 (2023)
Externí odkaz:
https://doaj.org/article/809eacb49e1c4dafa4e7d776f1a34874
Autor:
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro-inflammatory, which can augment inflammatory response, and GPR84 also func
Externí odkaz:
https://doaj.org/article/f928a8c42c4f4cda90c65d67e6687d23
Autor:
Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 12 (2023)
Free fatty acid receptor 2 (FFAR2) is activated by short-chain fatty acids and expressed widely, including in white adipocytes and various immune and enteroendocrine cells. Using both wild-type human FFAR2 and a designer receptor exclusively activate
Externí odkaz:
https://doaj.org/article/9b6b31128d5a4d21aaccb0f61f49509e
Autor:
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A. Anders, Franck Housseau, Amanda E. Mackenzie, Laura Jenkins, Graeme. Milligan, Shaoguang Wu, Cynthia L. Sears
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Boleij et al. show that G protein-coupled receptor 35 (GPR35) regulates the responses to enterotoxigenic Bacteroides fragilis (ETBF) in colonic epithelial cells. They find that GPR35-deficiency nearly protected mice from ETBF-induced death, suggestin
Externí odkaz:
https://doaj.org/article/2986eba9551643dc8608d3a4c5b5b496
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 11 (2022)
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via specific G-protein-coupled receptors
Externí odkaz:
https://doaj.org/article/0b08f246bde34112a3c8bb4e1ef6d6fa
Autor:
Sandra Siehler, Graeme Milligan
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane di
Autor:
Alice Valentini, Katrine Schultz-Knudsen, Anders Højgaard Hansen, Argyro Tsakoumagkou, Laura Jenkins, Henriette B. Christensen, Asmita Manandhar, Graeme Milligan, Trond Ulven, Elisabeth Rexen Ulven
Publikováno v:
Journal of Medicinal Chemistry. 66:6105-6121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::482dada4a45bab3f6a84a7ca63725381
https://doi.org/10.1021/acs.jmedchem.2c01935
https://doi.org/10.1021/acs.jmedchem.2c01935
Autor:
Graeme Milligan
Publikováno v:
Trends in Pharmacological Sciences. 44:263-273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d541f937d0a8fbd7d37adc730fa77b9
https://doi.org/10.1016/j.tips.2023.03.001
https://doi.org/10.1016/j.tips.2023.03.001
Autor:
Valentin Sencio, Adeline Barthelemy, Luciana P. Tavares, Marina G. Machado, Daphnée Soulard, Céline Cuinat, Celso Martins Queiroz-Junior, Marie-Louise Noordine, Sophie Salomé-Desnoulez, Lucie Deryuter, Benoit Foligné, Céline Wahl, Benoit Frisch, Angelica T. Vieira, Christophe Paget, Graeme Milligan, Trond Ulven, Isabelle Wolowczuk, Christelle Faveeuw, Ronan Le Goffic, Muriel Thomas, Stéphanie Ferreira, Mauro M. Teixeira, François Trottein
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2934-2947.e6 (2020)
Summary: Secondary bacterial infections often complicate viral respiratory infections. We hypothesize that perturbation of the gut microbiota during influenza A virus (IAV) infection might favor respiratory bacterial superinfection. Sublethal infecti
Externí odkaz:
https://doaj.org/article/09663ef56a7e41888b718db1c3193a50
Autor:
Paulius Viskaitis, Elaine E. Irvine, Mark A. Smith, Agharul I. Choudhury, Elisa Alvarez-Curto, Justyna A. Glegola, Darran G. Hardy, Silvia M.A. Pedroni, Maria R. Paiva Pessoa, Anushka B.P. Fernando, Loukia Katsouri, Alessandro Sardini, Mark A. Ungless, Graeme Milligan, Dominic J. Withers
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3559-3572 (2017)
Summary: Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in
Externí odkaz:
https://doaj.org/article/81e3234bc5b2496cb0686f51772bf269