Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Graeme, Mardon"'
Autor:
Hongsu Wang, Komal Kumar Bollepogu Raja, Kelvin Yeung, Carolyn A. Morrison, Antonia Terrizzano, Alireza Khodadadi-Jamayran, Phoenix Chen, Ashley Jordan, Cornelia Fritsch, Simon G. Sprecher, Graeme Mardon, Jessica E. Treisman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The integration of extrinsic signaling with cell-intrinsic transcription factors can direct progenitor cells to differentiate into distinct cell fates. In the developing Drosophila eye, differentiation of photoreceptors R1–R7 requires EGFR
Externí odkaz:
https://doaj.org/article/45d77916a65c4e9383934a0a35b2215b
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract The Drosophila eye has been an important model to understand principles of differentiation, proliferation, apoptosis and tissue morphogenesis. However, a single cell RNA sequence resource that captures gene expression dynamics from the initi
Externí odkaz:
https://doaj.org/article/5e03546cc0204130927c7bb86ef5bb06
Autor:
Jin Li, Jongsu Choi, Xuesen Cheng, Justin Ma, Shahil Pema, Joshua R. Sanes, Graeme Mardon, Benjamin J. Frankfort, Nicholas M. Tran, Yumei Li, Rui Chen
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109916- (2024)
Summary: Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity by characterizing cell types across tissues and species. While several mouse retinal scRNA-seq datasets exist, each dataset is either limited in
Externí odkaz:
https://doaj.org/article/65d6d83bef1f49cd8b7fecbf3affb4c8
Autor:
Samuel Kyobe, Grace Kisitu, Savannah Mwesigwa, John Farirai, Eric Katagirya, Gaone Retshabile, Lesedi Williams, Angela Mirembe, Lesego Ketumile, Misaki Wayengera, John Mukisa, Gaseene Sebetso, Thabo Diphoko, Marion Amujal, Edgar Kigozi, Fred Katabazi, Ronald Oceng, Busisiwe Mlotshwa, Koketso Morapedi, Betty Nsangi, Edward Wampande, Masego Tsimako, Chester Brown, Ishmael Kasvosve, Moses Joloba, Gabriel Anabwani, Sununguko Mpoloka, Graeme Mardon, Adeodata Kekitiinwa, Neil A. Hanchard, Jacqueline Kyosiimire–Lugemwa, Mogomotsi Matshaba, Dithan Kiragga
Publikováno v:
International Journal of Infectious Diseases, Vol 139, Iss , Pp 132-140 (2024)
Objectives: We utilize a large retrospective study cohort derived from electronic medical records to estimate the prevalence of long-term non-progression (LTNP) and determine the factors associated with progression among children infected with HIV in
Externí odkaz:
https://doaj.org/article/485968415239449bb3ea480de2a6ff4b
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract The Ets domain transcription factors direct diverse biological processes throughout all metazoans and are implicated in development as well as in tumor initiation, progression and metastasis. The Drosophila Ets transcription factor Pointed (
Externí odkaz:
https://doaj.org/article/01ed04b415a2487381024ef050e95aea
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The Drosophila eye is a powerful model system to study the dynamics of cell differentiation, cell state transitions, cell maturation, and pattern formation. However, a high-resolution single cell genomics resource that accurately profiles al
Externí odkaz:
https://doaj.org/article/ccf1e5b338da42ba961e46b607c11c7e
Autor:
John Mukisa, Marion Amujal, Obondo J. Sande, Moses L. Joloba, Daudi Jjingo, David P. Kateete, Graeme Mardon, Mogomotsi Matshaba, Neil Hanchard, Jill A. Hollenbach
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T
Externí odkaz:
https://doaj.org/article/7b34a82e753f41b8be9e240f53200078
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Single-cell RNA sequencing of early to mature adult Drosophila eyes reveals new cell type-specific marker genes and a full set of transcriptomic data for this tissue.
Externí odkaz:
https://doaj.org/article/83384164a44a4fd1a51c5a91c6a60eab
Autor:
Jiaxiong Lu, Kaitlyn Xiong, Xinye Qian, Jongsu Choi, Yoon-Kyung Shim, Jacob Burnett, Graeme Mardon, Rui Chen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract SPATA7, an early onset LCA3 retinal disease gene, encodes a putative scaffold protein that is essential for the proper assembly of the connecting cilium (CC) complex in photoreceptors. Previous studies have shown that SPATA7 interacts with o
Externí odkaz:
https://doaj.org/article/5d82f138b43d4ac29508e820ea293271
Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression
Autor:
Savannah Mwesigwa, Lesedi Williams, Gaone Retshabile, Eric Katagirya, Gerald Mboowa, Busisiwe Mlotshwa, Samuel Kyobe, David P. Kateete, Eddie Mujjwiga Wampande, Misaki Wayengera, Sununguko Wata Mpoloka, Angella N. Mirembe, Ishmael Kasvosve, Koketso Morapedi, Grace P. Kisitu, Adeodata R. Kekitiinwa, Gabriel Anabwani, Moses L. Joloba, Enock Matovu, Julius Mulindwa, Harry Noyes, Gerrit Botha, Collaborative African Genomics Network (CAfGEN), TrypanoGEN Research Group, Chester W. Brown, Graeme Mardon, Mogomotsi Matshaba, Neil A. Hanchard
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Human immunodeficiency virus (HIV) infection remains a significant public health burden globally. The role of viral co-infection in the rate of progression of HIV infection has been suggested but not empirically tested, particularly among ch
Externí odkaz:
https://doaj.org/article/ff623b751fa84b8e9c4699ec4ca85de2