Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Grady Phillips"'
Autor:
Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm, Gina Samuelson, Ross Coenen, Jacob Madison, Edward Doyle, Brendan Smyth, Grady Phillips, Michael Anne Gratton, Dominic Cosgrove
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237907 (2020)
Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracel
Externí odkaz:
https://doaj.org/article/001bf37035314cf5825014294244a997
Autor:
Duane Delimont, Brianna M Dufek, Daniel T Meehan, Marisa Zallocchi, Michael Anne Gratton, Grady Phillips, Dominic Cosgrove
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99083 (2014)
It has been known for some time that laminins containing α1 and α2 chains, which are normally restricted to the mesangial matrix, accumulate in the glomerular basement membranes (GBM) of Alport mice, dogs, and humans. We show that laminins containi
Externí odkaz:
https://doaj.org/article/0457708f8df442d291eef6080d41725c
Autor:
Dominic Cosgrove, Michael Anne Gratton, Jacob Madison, Denise Vosik, Gina Samuelson, Daniel Meehan, Duane Delimont, Grady Phillips, Brendan Smyth, Tiziano Pramparo, Diana Jarocki, Mai Nguyen, Radko Komers, Celia Jenkinson
Publikováno v:
The Journal of Pathology.
Autor:
Anna Lysakowski, Maria C. Perez-Flores, Grady Phillips, Jeong-Han Lee, Saeyeon Ju, Ebenezer N. Yamoah, Seojin Park, Michael Anne Gratton, Mincheol Kang, Guy Perkins
Publikováno v:
J Neurosci
Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca2+flux, and cellular biogenesis. Although the purposes of apposing m
Autor:
Gina Samuelson, Ruth M. Gill, Celia Jenkinson, Duane Delimont, Radko Komers, Jared J. Hartsock, Grady Phillips, Dominic Cosgrove, Michael Anne Gratton, James Hasson, Daniel T. Meehan, Brianna Dufek
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims In Alport syndrome (AS), endothelin type A receptor (ETAR) activation plays a role in both renal and inner ear pathologies. Currently, angiotensin converting enzyme inhibitors or angiotensin II type 1 receptor (AT1R) blockers are
Autor:
Grady Phillips, Daniel T. Meehan, Marisa Zallocchi, Michael Anne Gratton, Duane Delimont, Dominic Cosgrove, Brianna Dufek
Publikováno v:
Hearing Research. 341:100-108
Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Grady Phillips, Michael Anne Gratton, Duane Delimont, Deidre A. MacKenna, Gretchen Bain, Dominic Cosgrove, Daniel T. Meehan, Brianna Dufek, Michael Hartnett, Gina Samuelson
Publikováno v:
Kidney Int
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize
Publikováno v:
Otolaryngology–Head and Neck Surgery. 151:836-839
This pilot study compared otoprotection provided by trans-tympanic formulations and systemic intraperitoneal administration of L-N-acetylcysteine from cisplatin-induced cochlear oxidative stress. Protection was assessed by measures of hearing loss an
Publikováno v:
Journal of investigative surgery : the official journal of the Academy of Surgical Research. 29(3)
Surgical manipulation of the sensory and motor nerves of the rat tongue is often employed in studies evaluating the oral cavity functions of mastication and deglutition. A noninvasive, atraumatic approach that will then facilitate sufficient manipula