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Single-cell analysis can define distinct evolution of tumor sites in follicular lymphoma

Autor: Hojoon Lee, Hanlee P. Ji, Michael S. Binkley, Grady Day, Sarah Haebe, Steven R. Long, Brock A. Martin, Ronald Levy, Debra K. Czerwinski, Susan M. Grimes, Tanaya Shree, Anuja Sathe

Publikováno v: Blood. 137:2869-2880

Tumor heterogeneity complicates biomarker development and fosters drug resistance in solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical implications is still limited. Here, we profiled 2 nodal, synchronously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4052a60274e0de78d15a1b9926cbeb18
https://doi.org/10.1182/blood.2020009855

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In Situ Vaccination Induces Changes in Follicular Lymphoma Tumor Cells That Correlate with Abscopal Clinical Regressions

Autor: Brock A. Martin, Hanlee P. Ji, Ronald Levy, Susan M. Grimes, Anuja Sathe, Sarah Haebe, Richard T. Hoppe, Tanaya Shree, Grady Day, Debra K. Czerwinski, Steven R. Long

Publikováno v: Blood. 138:2407-2407

The efficacy of an induced anti-tumor immune response is determined by a dynamic interaction and co-evolution of tumor cells and their microenvironment, leading to continuous changes in cellular and molecular properties of the tumor. Therefore, longi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af5ebccd32c95a90053bb6cc3dccc624
https://doi.org/10.1182/blood-2021-154115

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Therapeutic and Immunologic Responses Elicited By in Situ Vaccination with CpG, Ibrutinib, and Low-Dose Radiation

Autor: Sara Beygi, Matthew J. Frank, Michael S. Khodadoust, Richard T. Hoppe, Hanlee P. Ji, Tanaya Shree, Ronald Levy, Sarah Haebe, Grady Day, Brock A. Martin, Anuja Sathe, Steven R. Long, Debra K. Czerwinski

Publikováno v: Blood. 138:3539-3539

Introduction: In situ vaccination aims to induce an immune response locally at one tumor site that propagates systemically to all tumor sites. This approach can be effective in indolent lymphoma (Brody et al., JCO 2010, Frank et al., Cancer Discov 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::742bcbe87635c06d87400f258221ae5e
https://doi.org/10.1182/blood-2021-154017

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Determining Canine Blood and Human Blood Composition by Congealing Microliter Drops into Homogeneous Thin Solid Films (HTSFs) via HemaDrop™

Autor: Grady Day, Alvaro Martinez, Barry Wilkens, M.W. Mangus, Nicole Herbots, Sabrina Suhartono, Robert Culbertson, Ryan van Haren, S.D. Whaley, Yash Pershad

Publikováno v: MRS Advances. 2:2451-2456

Accurate analysis of microliter blood samples can improve patient care during medical testing and forensics. Patients can suffer from anemia due to the larger volume required for blood tests, 7 milliliters per vial. Attempts at analysis of nanoliter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac4d002dd79ea795a6aeaf610c3dfc5
https://doi.org/10.1557/adv.2017.479

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Single Cell Analysis of Serial Lymphoma Biopsies Reveals Dynamic Immune Modulation and Predictors of Response in Patients Undergoing in Situ Vaccination

Autor: Grady Day, Debra K. Czerwinski, Anuja Sathe, Hanlee P. Ji, Brock A. Martin, Hojoon Lee, Steven R. Long, Sarah Haebe, Susan M. Grimes, Tanaya Shree, Ronald Levy

Publikováno v: Blood. 136:36-37

Introduction: In situ vaccination aims to induce an immune response locally at one tumor site, that propagates systemically to all tumor sites. Prior clinical studies have demonstrated that this strategy can be effective in indolent lymphoma (Brody e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e95f908d46cff3f50a30424f244ff3f5
https://doi.org/10.1182/blood-2020-141672

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Dynamic Immune Modulation Seen By Single Cell RNA-Sequencing of Serial Lymphoma Biopsies in Patients Undergoing in Situ Vaccination

Autor: Anuja Sathe, Hanlee P. Ji, Hojoon Lee, Tanaya Shree, Debra K. Czerwinski, Grady Day, Sarah Haebe, Ronald Levy, Susan M. Grimes

Publikováno v: Blood. 134:1479-1479

It is increasingly evident that the composition of the tumor microenvironment (TME) and the interplay between malignant and immune cells determine the efficacy of antitumor immune responses, whether pre-existing or induced by therapy. To profile the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c55078fcee5640813d312078528025dd
https://doi.org/10.1182/blood-2019-131684

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Site to Site Comparison of Follicular Lymphoma Biopsies By Single Cell RNA Sequencing

Autor: Tanaya Shree, Grady Day, Hanlee P. Ji, Anuja Sathe, Hojoon Lee, Sarah Haebe, Susan M. Grimes, Ronald Levy, Debra K. Czerwinski

Publikováno v: Blood. 134:297-297

Follicular lymphoma (FL) originates from a single B cell that has rearranged one copy of its BCL2 gene on chromosome 18 to the Ig locus on chromosome 14 and in addition has acquired a mutation in a histone modifying gene such as CREBBP or KMTD2. By t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0daa037420617481247172378c054e
https://doi.org/10.1182/blood-2019-129445

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