Zobrazeno 1 - 10 of 120 pro vyhledávání: '"Gradoux N"'
1
Akademický článek
Role of Na + -K + ATPase Alterations in the Development of Heart Failure.
Autor: Dhalla, Naranjan S.1,2 (AUTHOR) nsdhalla@sbrc.ca, Elimban, Vijayan1 (AUTHOR), Adameova, Adriana Duris3 (AUTHOR) adriana.duris.adameova@uniba.sk
Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10807. 20p.
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2
Akademický článek
Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Autor: Mainolfi N; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ehara T; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Karki RG; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Anderson K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Mac Sweeney A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Liao SM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Argikar UA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Jendza K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Zhang C; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Powers J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Klosowski DW; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Crowley M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Kawanami T; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ding J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., April M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Forster C; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Serrano-Wu M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Capparelli M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ramqaj R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Solovay C; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Cumin F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Smith TM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ferrara L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Lee W; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Long D; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Prentiss M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., De Erkenez A; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Yang L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Liu F; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Sellner H; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Sirockin F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Valeur E; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Erbel P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Ostermeier D; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Ramage P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Gerhartz B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Schubart A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Flohr S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Gradoux N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Feifel R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Vogg B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Wiesmann C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Maibaum J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Eder J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Sedrani R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Harrison RA; Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland., Mogi M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Jaffee BD; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Adams CM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 5697-5722. Date of Electronic Publication: 2020 Feb 19.
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3
Akademický článek
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Autor: Karki RG; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Powers J; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Mainolfi N; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Anderson K; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Belanger DB; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Liu D; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Ji N; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Jendza K; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Gelin CF; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Mac Sweeney A; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., Solovay C; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Delgado O; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Crowley M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Liao SM; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Argikar UA; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Flohr S; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., La Bonte LR; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Lorthiois EL; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., Vulpetti A; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., Brown A; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Long D; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Prentiss M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Gradoux N; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., de Erkenez A; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Cumin F; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland., Adams C; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Jaffee B; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States., Mogi M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 09; Vol. 62 (9), pp. 4656-4668. Date of Electronic Publication: 2019 Apr 30.
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4
Akademický článek
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5
Akademický článek
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6
Akademický článek
Fluorescence Lifetime-Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro.
Autor: Boettcher A; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Gradoux N; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Lorthiois E; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Brandl T; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Orain D; Novartis Institutes for BioMedical Research (NIBR), Global Discovery Chemistry, Novartis Pharma AG, Basel, Switzerland., Schiering N; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Cumin F; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Woelcke J; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland., Hassiepen U; Novartis Institutes for BioMedical Research (NIBR), Expertise Platform Proteases, Novartis Pharma AG, Basel, Switzerland ulrich.hassiepen@novartis.com.
Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2014 Jul; Vol. 19 (6), pp. 870-7. Date of Electronic Publication: 2014 Jan 31.
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7
Akademický článek
Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease.
Autor: Baloglu, Emel1 (AUTHOR) emel.baloglu@acibadem.edu.tr
Publikováno v: International Journal of Molecular Sciences. May2023, Vol. 24 Issue 9, p7855. 20p.
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8
Akademický článek
Differential regulation of intestinal and liver fatty acid-binding proteins in human intestinal cell line (Caco-2): role of collagen.
Autor: Darimont C; Metabolic and Cardiovascular Diseases, Novartis Pharma AG, Basel, CH-4002, Switzerland., Gradoux N, Cumin F, Baum HP, De Pover A
Publikováno v: Experimental cell research [Exp Cell Res] 1998 Nov 01; Vol. 244 (2), pp. 441-7.
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9
Akademický článek
Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts.
Autor: Shamraj OI; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, Ohio., Grupp IL, Grupp G, Melvin D, Gradoux N, Kremers W, Lingrel JB, De Pover A
Publikováno v: Cardiovascular research [Cardiovasc Res] 1993 Dec; Vol. 27 (12), pp. 2229-37.
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10
Akademický článek
Halting targeted and collateral damage to red blood cells by the complement system.
Autor: Jalink, M.1,2 (AUTHOR), de Boer, E. C. W.3,4 (AUTHOR), Evers, D.5 (AUTHOR), Havinga, M. Q.3 (AUTHOR), Vos, J. M. I.2,6,7 (AUTHOR), Zeerleder, S.3,8,9 (AUTHOR), de Haas, M.1,7,10 (AUTHOR), Jongerius, I.3,4 (AUTHOR) i.jongerius@sanquin.nl
Publikováno v: Seminars in Immunopathology. Dec2021, Vol. 43 Issue 6, p799-816. 18p.
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