Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Graciella Andrei"'
Autor:
Graciella Andrei, Yosuke Demizu, Tokumi Maruyama, Christophe Pannecouque, Myriam Witvrouw, Jan Balzarini, Shigetada Kozai, Robert Snoecks, Erik De Clercq
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 26:1553-1558
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e76dfd6df77bc71cab0d5509383477
https://doi.org/10.1080/15257770701545424
https://doi.org/10.1080/15257770701545424
Autor:
Erik De Clercq, Shigetada Kozai, Robert Snoeck, Myriam Witvrouw, Tokumi Maruyama, Christophe Pannecouque, Graciella Andrei, Jan Balzarini, Tetsuo Yamasaki
Publikováno v:
ResearcherID
The development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) is an efficient strategy for finding new therapeutic agents against human immunodeficiency virus (HIV). A large number of 6-substituted uracil derivatives have been prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0f6ccd223fc45eae5493db0b383ce2
https://doi.org/10.1177/095632020301400506
https://doi.org/10.1177/095632020301400506
Autor:
Christophe Galtier, Robert Snoeck, Graciella Andrei, Jan Balzarini, Erik De Clercq, Alain Gueiffier, Sylvie Mavel, Jean‐Louis Renou, Hassan Allouchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:941-946
The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1f094650cf22631a5b92da5bddb279
https://doi.org/10.1016/s0968-0896(01)00347-9
https://doi.org/10.1016/s0968-0896(01)00347-9
Autor:
Alain Gueiffier, Jean‐Louis Renou, Christophe Galtier, Jan Balzarini, Sylvie Mavel, Robert Snoeck, Hassan Allouchi, Erik De Clercq, Graciella Andrei
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c2e8de74dd2b3a37850b4f5564767aa
https://doi.org/10.1002/chin.200220121
https://doi.org/10.1002/chin.200220121
Autor:
Graciella Andrei, Myriam Witvrouw, Robert Snoecks, Tokumi Maruyama, Yosuke Demizu, Jan Balzarini, Shigetada Kozai, Christophe Pannecouque, Erik De Clercq
Publikováno v:
ChemInform. 39
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a9ad03e338b411700346270ce004da
https://doi.org/10.1002/chin.200813255
https://doi.org/10.1002/chin.200813255
Autor:
Erik De Clercq, Christophe Pannecouque, Yosuke Demizu, Jan Balzarini, Myriam Witvrouw, Tokumi Maruyama, Graciella Andrei, Robert Snoeck, Shigetada Kozai
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
1,3-disubstituted uracils were obtained from uracil by the stepwise alkylation at N-1 and N-3 position with alkyl halide/alkali or alcohol under Mitsunobu conditions. The antiviral activity against HIV-1 of these compounds was examined to find that 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f05f61d43616dfc40fd7f396cd9af9
https://pubmed.ncbi.nlm.nih.gov/17150449
https://pubmed.ncbi.nlm.nih.gov/17150449
Autor:
Yosuke Demizu, Robert Snoecks, Graciella Andrei, Tokumi Maruyama, Myriam Witvrouw, Christophe Pannecouque, Jan Balzarini, Shigetada Kozai, Erik De Clercq
Publikováno v:
ChemInform. 37
3-(3,5-Dimethylbenzyl)uracil (3) was treated with alkyl halides in the presence of alkali to give 1-substituted congeners. Condensation of 3 with alcohols using the Mitsunobu reaction was also employed as an alternative method. The anti-HIV-1 activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fd0b4884acbde6225f21e1a2af84b1
https://doi.org/10.1002/chin.200634151
https://doi.org/10.1002/chin.200634151
Autor:
Sally Blewett, Alison Jukes, Robert Snoeck, Jan Balzarini, Jonathan T. Erichsen, Christopher McGuigan, Graciella Andrei, Erik De Clercq, Hubert Barucki
Publikováno v:
ResearcherID
Bicyclic furano pyrimidines have been previously reported by us to be highly potent and selective inhibitors of varicella zoster virus (VZV). p-Alkyl phenyl analogues are particularly potent with EC50 values below 1nM. In this article we report the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121e182dbb171eadbdb87c8b2a73d570
https://pubmed.ncbi.nlm.nih.gov/14521333
https://pubmed.ncbi.nlm.nih.gov/14521333
Autor:
Robert Snoeck, Christopher McGuigan, Marco Derudas, Jan Balzarini, Erik De Clercq, Graciella Andrei
Publikováno v:
Antiviral Research. 74:A72-A72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc178bd4095653fe00b44fab8d02a42
https://doi.org/10.1016/j.antiviral.2007.01.116
https://doi.org/10.1016/j.antiviral.2007.01.116
Publikováno v:
ResearcherID
Human cytomegalovirus (HCMV) infections are usually benign and self-limiting in the immunocompetent population; however, HCMV is a well-recognized problem among immunocompromised patients (in particular immunosuppressed patients with stem cell or sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362da0572fbc02c6a1a935a8d8dcaf20
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BCI&KeyUT=BCI:BCI200900395501&KeyUID=BCI:BCI200900395501
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BCI&KeyUT=BCI:BCI200900395501&KeyUID=BCI:BCI200900395501
