Výsledky vyhledávání - "Graciela C. Calabrese"

Design and synthesis of peptides from Phoneutria nigriventer δ-ctenitoxin-Pn2a for antivenom production

Autor: Jésica A. Rodríguez, Gabriela R. Barredo-Vacchelli, Lucía C. Iglesias-García, Ariadna M. Birocco, Agustín Blachman, Graciela C. Calabrese, Gerardo Acosta, Fernando Albericio, Silvia A. Camperi

The venom toxin δ-ctenitoxin-Pn2a of the spider Phoneutria nigriventer can cause severe envenomation in humans. Furthermore, the cystine-knot motif of δ-ctenitoxin-Pn2a provides exceptional stability, thereby hampering immune response activation. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c8099c9fcbf1566eeea5af1c942de0
https://doi.org/10.21203/rs.3.rs-2160682/v1

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Dermatan sulfate/chitosan polyelectrolyte complex with potential application in the treatment and diagnosis of vascular disease

Autor: Luciana Gualco, Julieta Celeste Imperiale, Roxana Oberkersch, Alejandro Sosnik, Rita Yanina Rasente, Juan Manuel Lázaro-Martínez, Graciela C. Calabrese

Publikováno v: Carbohydrate Polymers. 144:362-370

Cardiovascular disease is the largest single cause of morbid-mortality in the world. However, there is still no pharmaceutical treatment that directly targets the blood vessel wall instead of just controlling the risk factors. Here, we produced polye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95f07cfb95dc8576bd09a85502a33f8
https://doi.org/10.1016/j.carbpol.2016.02.046

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Targeted anti-inflammatory peptide delivery in injured endothelial cells using dermatan sulfate/chitosan nanomaterials

Autor: Silvia A. Camperi, Juan Manuel Lázaro-Martínez, Romina Julieta Glisoni, Florencia Funez, Ariadna M. Birocco, Alejandro Sosnik, Agustín Blachman, Graciela C. Calabrese, Soledad L. Saavedra

Publikováno v: Carbohydrate Polymers. 230:115610

This work describes a novel delivery system for targeting egg-derived anti-inflammatory tripeptide Ile-Arg-Trp (IRW) to endothelial cells. The nanomedicine is synthesized by a simple and reproducible ionotropic gelification method that results in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbb761a64c3d541f85169924ca52413
https://doi.org/10.1016/j.carbpol.2019.115610

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Learning from Synthetic Models of Extracellular Matrix; Differential Binding of Wild Type and Amyloidogenic Human Apolipoprotein A-I to Hydrogels Formed from Molecules Having Charges Similar to Those Found in Natural GAGs

Autor: Leandro Toledo, Graciela C. Calabrese, M. Alejandra Tricerri, Bruno F. Urbano, Silvana Antonia Rosu, Susana A. Sanchez

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Protein Journal
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Among other components of the extracellular matrix (ECM), glycoproteins and glycosaminoglycans (GAGs) have been strongly associated to the retention or misfolding of different proteins inducing the formation of deposits in amyloid diseases. The compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423b6068a13204e3389214b2bdde2108
https://link.springer.com/article/10.1007/s10930-017-9728-8

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VLDL Induced Modulation of Nitric Oxide Signalling and Cell Redox Homeostasis in HUVEC

Autor: Graciela C. Calabrese, Yasmine Grooten, Azzurra Mollo, Paolo Sarti, Maria Chiara Magnifico, Roxana Oberkersch, Luca Giambelli, Marzia Arese

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity

High levels of circulating lipoprotein constitute a risk factor for cardiovascular diseases, and in this context, the specific role of the very-low-density lipoproteins (VLDL) is poorly understood. The response of human umbilical vein endothelial cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2498a813194642ab20126883b093af5

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Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate

Autor: Graciela C. Calabrese, Maria Fabiana Alberto, Diego Giaquinta Romero, Maria A. Lazzari

Publikováno v: Thrombosis Research. 122:109-116

Dermatan sulfate, a sulfated glycosaminoglycan, acts as an anticoagulant by accelerating the inhibition of thrombin by heparin cofactor II.A low molecular mass dermatan sulfate was obtained by peroxy-radical depolymerization from a parent dermatan su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2447e5ce721499d78448bbca60d667
https://doi.org/10.1016/j.thromres.2007.09.001

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Tissue expression of platelet endothelial cell adhesion molecule-1 at pre and postnatal murine development

Autor: Graciela C. Calabrese, Rosa Wainstok

Publikováno v: BIOCELL. 28:251-258

Endothelial cells, at the cell-cell borders, express PECAM-1, and have been implicated in vascular functions. The monoclonal antibody MEC 13.3 recognizes PECAM-1 molecule from mouse vessels and allows to analyze the ontogeny of mouse endothelium. At

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60aff4663e2f24e45990d578f261dd21
https://doi.org/10.32604/biocell.2004.28.251

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Atheroprotective remodelling of vascular dermatan sulphate proteoglycans in response to hypercholesterolaemia in a rat model

Autor: Roxana Oberkersch, Francesca Maccari, Alicia I. Bravo, Nicola Volpi, Graciela C. Calabrese, Silvina Gazzaniga

Factors that determine early atherosclerotic lesions are unknown, but the vascular extracellular matrix (ECM) appears to be involved. Two hypotheses, which directly or indirectly reflect ECM involvement, have been proposed to explain the early molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08717717f2a9d3bf41f2dfe100a030e1
https://europepmc.org/articles/PMC4351854/

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