Synthesis and Characterization of Novel Surfactants Based on 2-Hydroxy-4-(methylthio)butanoic Acid: 2. Non-ionic Surfactants

Autor: Scott A. Long, Jeffrey H. Harwell, Kyle A. Karinshak, Graciela B Arhancet, Guangzhe Yu, Brian P. Grady

Publikováno v: Journal of Surfactants and Detergents. 20:503-519

Hydroxy-4-(methylthio)butanoic acid (HMTBA) is a commonly used animal feed additive available in large quantities. In this study, anionic surfactants were synthesized utilizing HMTBA as a starting material. Specifically, a straight- chain fatty acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10aa9025700ece3c2606d6b936785a30
https://doi.org/10.1007/s11743-016-1915-7

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Autor: John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:1114-1119

Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121fd58b89ecf308dd263c517c877ef
https://doi.org/10.1016/j.bmcl.2012.11.109

Discovery of Novel Cyanodihydropyridines as Potent Mineralocorticoid Receptor Antagonists

Autor: Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle

Publikováno v: Journal of Medicinal Chemistry. 53:5970-5978

A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ

Autor: Charles W. Bolten, Patrick M. Blanner, William G. McDonald, Nicholas R. Staten, Richard A. Mazzarella, Graciela B. Arhancet, Martin F. Meier, David J. Weiss, Patrick M. Sullivan, Alexander E. Hromockyj, Rolf F. Kletzien, Jerry R. Colca

Publikováno v: Gene Regulation and Systems Biology, Vol 1, Pp 73-82 (2007)
Gene Regulation and Systems Biology, Vol 1 (2007)
Gene Regulation and Systems Biology

Insulin sensitizing thiazolidinediones (TZDs) are generally considered to work as agonists for the nuclear receptor peroxisome proliferative activated receptor-gamma (PPAR gamma). However, TZDs also have acute, non-genomic metabolic effects and it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb348030b9f5e16dbbb594e56cee8404
http://la-press.com/article.php?article_id=370

Thermolysis of a Tertiary Alkoxyamine. Recombination and Disproportionation of α-Phenethyl/Diethyl Nitroxyl Radical Pairs

Autor: Shaoming Duan, Paul S. Engel, Graciela B. Arhancet

Publikováno v: The Journal of Organic Chemistry. 62:3537-3541

Alkoxyamine 3 undergoes thermolysis only on heating to over 150 °C, ΔH⧧ = 34.3 ± 1.6 kcal/mol and ΔS⧧ = 0.8 ± 3.7 eu. The initially formed nitroxyl (6) and α-phenethyl radicals (5) mainly disproportionate to styrene plus diethylhydroxylamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91e46e15d5710f650850a2df9c6b4a92
https://doi.org/10.1021/jo961852d