Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons.

Autor: Graciano Leal, Pedro M Afonso, Carlos B Duarte

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108175 (2014)

Dendritic protein synthesis plays a critical role in several forms of synaptic plasticity, including BDNF (brain-derived neurotrophic factor)-mediated long-term synaptic potentiation (LTP). Dendritic transcripts are typically transported in a repress

Externí odkaz: https://doaj.org/article/d3b71e8bbdaa45dc91aa895ad345bde8

Pesquisa e ensino na história escolar: o contexto urbano da Escola Terezinha Paulino em Natal-RN

Autor: Fernandes, Cícera Tamara Graciano Leal da Silva

Publikováno v: Repositório Institucional da UFRN
Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN

Esta pesquisa de Mestrado objetivou, principalmente, relacionar a realidade do entorno da escola à construção do conhecimento histórico, buscando, ainda: determinar como se deu o seu crescimento urbano; levantar suas narrativas de memória locais

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::5aa6dba74dd2e63806bb625d97f99860
https://repositorio.ufrn.br/jspui/handle/123456789/26748

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons

Autor: Birgitte Berentsen, Miranda Mele, Ramiro D. Almeida, Rui Costa, Luís Rodrigues, Ana Rita Santos, Clive R. Bramham, Laura Carreto, Carlos B. Duarte, Maria J. Pinto, Pedro M. Afonso, Pasqualino De Luca, Manuel A. S. Santos, Eduardo Morais, Paulo S. Pinheiro, Diogo Comprido, Sudarshan Patil, Graciano Leal, Ka Wan Li

Publikováno v: Leal, G, Comprido, D, de Luca, P, Morais, E, Rodrigues, L, Mele, M, Santos, A R, Costa, R O, Pinto, M J, Patil, S, Berentsen, B, Afonso, P, Carreto, L, Li, K W, Pinheiro, P, Almeida, R D, Santos, M A S, Bramham, C R & Duarte, C B 2017, ' The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons ', eNeuro, vol. 4, no. 6, e0268-17.2017 . https://doi.org/10.1523/ENEURO.0268-17.2017
eNeuro
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
eNeuro, 4(6):e0268-17.2017. Society for Neuroscience

Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the delivery of transcripts to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304051d047be789fa4604fb6381c93c3
https://research.vu.nl/en/publications/9b6ae25e-cfd3-46ca-86ee-ba693de2fbc2

Role of GABA

Autor: Miranda, Mele, Graciano, Leal, Carlos B, Duarte

Publikováno v: Journal of neurochemistry. 139(6)

Neuronal excitability depends on the balance between inhibitory and excitatory neurotransmission, which in the CNS are mainly mediated by GABA and glutamate respectively. The plasticity of glutamatergic synapses and the underlying molecular mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca11da3137a7b5ba51172af2a6802744
https://pubmed.ncbi.nlm.nih.gov/27424566

Regulation of hippocampal synaptic plasticity by BDNF

Autor: Carlos B. Duarte, Pedro M. Afonso, Graciano Leal, Ivan L. Salazar

Publikováno v: Brain research. 1621

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of activity-dependent plasticity at excitatory synapses in the mammalian central nervous system. In particular, much attention has been given to the role of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367036d0130433d480c5710e66850616
https://pubmed.ncbi.nlm.nih.gov/25451089