Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Graciano Leal"'
Autor:
Wibke Singer, Marie Manthey, Rama Panford-Walsh, Lucas Matt, Hyun-Soon Geisler, Eleonora Passeri, Gabriele Baj, Enrico Tongiorgi, Graciano Leal, Carlos B. Duarte, Ivan L. Salazar, Philipp Eckert, Karin Rohbock, Jing Hu, Jörg Strotmann, Peter Ruth, Ulrike Zimmermann, Lukas Rüttiger, Thomas Ott, Thomas Schimmang, Marlies Knipper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network chang
Externí odkaz:
https://doaj.org/article/3cb0c2e2e5294877a4c2b7fa0e4a4b48
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108175 (2014)
Dendritic protein synthesis plays a critical role in several forms of synaptic plasticity, including BDNF (brain-derived neurotrophic factor)-mediated long-term synaptic potentiation (LTP). Dendritic transcripts are typically transported in a repress
Externí odkaz:
https://doaj.org/article/d3b71e8bbdaa45dc91aa895ad345bde8
Autor:
Márcio S Baptista, Carlos V Melo, Mário Armelão, Dennis Herrmann, Diogo O Pimentel, Graciano Leal, Margarida V Caldeira, Ben A Bahr, Mário Bengtson, Ramiro D Almeida, Carlos B Duarte
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10139 (2010)
Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms--GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional c
Externí odkaz:
https://doaj.org/article/9513d2b9c41945138b839630244cf091
Publikováno v:
Repositório Institucional da UFRN
Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
Esta pesquisa de Mestrado objetivou, principalmente, relacionar a realidade do entorno da escola à construção do conhecimento histórico, buscando, ainda: determinar como se deu o seu crescimento urbano; levantar suas narrativas de memória locais
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3056::5aa6dba74dd2e63806bb625d97f99860
https://repositorio.ufrn.br/jspui/handle/123456789/26748
https://repositorio.ufrn.br/jspui/handle/123456789/26748
Publikováno v:
Journal of Neurochemistry. 139:997-1018
Neuronal excitability depends on the balance between inhibitory and excitatory neurotransmission, which in the CNS are mainly mediated by GABA and glutamate respectively. The plasticity of glutamatergic synapses and the underlying molecular mechanism
Autor:
Birgitte Berentsen, Miranda Mele, Ramiro D. Almeida, Rui Costa, Luís Rodrigues, Ana Rita Santos, Clive R. Bramham, Laura Carreto, Carlos B. Duarte, Maria J. Pinto, Pedro M. Afonso, Pasqualino De Luca, Manuel A. S. Santos, Eduardo Morais, Paulo S. Pinheiro, Diogo Comprido, Sudarshan Patil, Graciano Leal, Ka Wan Li
Publikováno v:
Leal, G, Comprido, D, de Luca, P, Morais, E, Rodrigues, L, Mele, M, Santos, A R, Costa, R O, Pinto, M J, Patil, S, Berentsen, B, Afonso, P, Carreto, L, Li, K W, Pinheiro, P, Almeida, R D, Santos, M A S, Bramham, C R & Duarte, C B 2017, ' The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons ', eNeuro, vol. 4, no. 6, e0268-17.2017 . https://doi.org/10.1523/ENEURO.0268-17.2017
eNeuro
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
eNeuro, 4(6):e0268-17.2017. Society for Neuroscience
eNeuro
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
eNeuro, 4(6):e0268-17.2017. Society for Neuroscience
Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the delivery of transcripts to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304051d047be789fa4604fb6381c93c3
https://research.vu.nl/en/publications/9b6ae25e-cfd3-46ca-86ee-ba693de2fbc2
https://research.vu.nl/en/publications/9b6ae25e-cfd3-46ca-86ee-ba693de2fbc2
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out among all neurotrophins by its high expression levels in the brain and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56749323659e28cbca69d4dc76947afa
https://doi.org/10.1016/bs.vh.2016.10.004
https://doi.org/10.1016/bs.vh.2016.10.004
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF
Autor:
Carlos B. Duarte, Ivan L. Salazar, Carlos V. Melo, Michele Curcio, Margarida V. Caldeira, Paulo Pereira, Miranda Mele, Ana Rita Santos, Graciano Leal, Lorella M.T. Canzoniero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832(1):263-274
Overactivation of glutamate receptors contributes to neuronal damage (excitotoxicity) in ischemic stroke but the detailed mechanisms are not fully elucidated. Brain ischemia is also characterized by an impairment of the activity of the proteasome, on
Publikováno v:
Journal of neurochemistry. 139(6)
Neuronal excitability depends on the balance between inhibitory and excitatory neurotransmission, which in the CNS are mainly mediated by GABA and glutamate respectively. The plasticity of glutamatergic synapses and the underlying molecular mechanism