Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort

Autor: Simuni, T, Merchant, K, Brumm, MC, Cho, H, Caspell-Garcia, C, Coffey, CS, Chahine, LM, Alcalay, RN, Nudelman, K, Foroud, T, Mollenhauer, B, Siderowf, A, Tanner, C, Iwaki, H, Sherer, T, Marek, K, Seibyl, J, Coffey, C, Tosun-Turgut, D, Shaw, LM, Trojanowski, JQ, Singleton, A, Kieburtz, K, Toga, A, Galasko, D, Poewe, W, Poston, K, Bressman, S, Reimer, A, Arnedo, V, Clark, A, Frasier, M, Kopil, C, Chowdhury, S, Casaceli, C, Dorsey, R, Wilson, R, Mahes, S, Salerno, C, Ahrens, M, Brumm, M, Cho, HR, Fedler, J, LaFontant, D-E, Kurth, R, Crawford, K, Casalin, P, Malferrari, G, Weisz, MG, Orr-Urtreger, A, Trojanowski, J, Shaw, L, Montine, T, Baglieri, C, Christini, A, Russell, D, Dahodwala, N, Giladi, N, Factor, S, Hogarth, P, Standaert, D, Hauser, R, Jankovic, J, Saint-Hilaire, M, Richard, I, Shprecher, D, Fernandez, H, Brockmann, K, Rosenthal, L, Barone, P, Espayc, A, Rowe, D, Marder, K, Santiago, A, Hu, S-C, Isaacson, S, Corvol, J-C, Martinez, JR, Tolosa, E, Tai, Y, Politis, M, Smejdir, D, Rees, L, Williams, K, Kausar, F, Richardson, W, Willeke, D, Peacock, S, Sommerfeld, B, Freed, A, Wakeman, K, Blair, C, Guthrie, S, Harrell, L, Hunter, C, Thomas, C-A, James, R, Zimmerman, G, Brown, V, Mule, J, Hilt, E, Ribb, K, Ainscough, S, Wethington, M, Ranola, M, Santana, HM, Moreno, J, Raymond, D, Speketer, K, Carvajal, L, Carvalo, S, Croitoru, I, Garrido, A, Payne, LM, Viswanth, V, Severt, L, Facheris, M, Soares, H, Mintun, MA, Cedarbaum, J, Taylor, P, Biglan, K, Vandenbroucke, E, Sheikh, ZH, Bingol, B, Fischer, T, Sardi, P, Forrat, R, Reith, A, Egebjerg, J, Hillert, GA, Saba, B, Min, C, Umek, R, Mather, J, De Santi, S, Post, A, Boess, F, Taylor, K, Grachev, I, Avbersek, A, Muglia, P, Tauscher, J

We examined 2-year longitudinal change in clinical features and biomarkers in LRRK2 non-manifesting carriers (NMCs) versus healthy controls (HCs) enrolled in the Parkinson’s Progression Markers Initiative (PPMI). We analyzed 2-year longitudinal dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::57cb78cbdcff5c5771194646efb11352
http://hdl.handle.net/10044/1/101202

Tracking greenery across a latitudinal gradient in central Asia -the migration of the saiga antelope

Autor: Singh, N. J., Grachev, I. A., Bekenov, A. B., Milner-Gulland, E. J.

Publikováno v: Diversity and Distributions, 2010 Jul 01. 16(4), 663-675.

Externí odkaz: http://dx.doi.org/10.1111/j.1472-4642.2010.00671.x

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study

Autor: Grachev, I. D., Meyer, P. M., Becker, G. A., Bronzel, M., Marsteller, D., Pastino, G., Voges, O., Rabinovich, L., Knebel, H., Zientek, F., Rullmann, M., Sattler, B., Patt, M., Gerhards, T., Strauss, M., Kluge, A., Brust, P., Savola, J.-M., Gordon, M. F., Geva, M., Hesse, S., Barthel, H., Hayden, M. R., Sabri, O.

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging (2021)

Purpose: Pridopidine is an investigational drug for Huntington disease (HD). Pridopidine was originally thought to act as a dopamine stabilizer. However, pridopidine shows highest affinity to the sigma-1 receptor (S1R) and enhances neuroprotection vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::8ab4a0db533b975bb49d0f4204eef244
https://www.hzdr.de/publications/Publ-31618-1

Relying on the National Innovation System as a Necessary Condition to Implement National Projects.

Autor: Grachev, I. D., Nekrasov, S. A.

Publikováno v: Herald of the Russian Academy of Sciences; Jul2020, Vol. 90 Issue 4, p406-416, 11p

Interim results of Transpher A, a multicentre, single-dose, phase 1/2 clinical trial of ABO-102 investigational gene therapy for Sanfilippo syndrome type A (mucopolysaccharidosis IIIA)

Autor: Flanigan, Kevin M., Smith, Nicholas J.N., Couce, Maria L., Escolar, Maria, Truxal, Kristen V., McBride, Kim L., de Castro, Maria J., Fuller, Maria, Pañeda, A., Ruiz, J., del Campo, A.B., Grachev, I.

Publikováno v: In Molecular Genetics and Metabolism February 2022 135(2):S43-S43