Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Grace R. Nakayama"'
1
A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase
Autor: Patrick Bingham, Grace R Nakayama, Karen A. Maegley, Douglas H. Tan
Publikováno v: Analytical Biochemistry. 351:260-265
A fluorescence polarization (FP) microplate assay suitable for screening compounds against the ribonuclease H (RNase H) activity of HIV-1 reverse transcriptase has been developed. This homogeneous assay uses a hybrid 18-mer DNA/RNA duplex substrate c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cdade7ee214609c5922fb3761063ad
https://doi.org/10.1016/j.ab.2006.01.045
Zobrazit plný text záznamu
2
Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inhibitors
Autor: Mike Westby, Scott L. Butler, Grace R Nakayama, Wade S. Blair
Publikováno v: Antiviral Research. 67:121-140
The identification of novel HIV-1 inhibitors is facilitated by screening campaigns that combine the right screening strategy with a large diverse collection of drug-like compounds. Cell-based screening approaches offer some advantages in the quest fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3177bee8d328c6432fb7340658ec220
https://doi.org/10.1016/j.antiviral.2005.06.006
Zobrazit plný text záznamu
4
Improving the copy numbers of antibody fragments expressed on the major coat protein of bacteriophage M13
Autor: Gunars Valkirs, William D. Husea, Diane McGrath, Grace R. Nakayama
Publikováno v: Immunotechnology. 2:197-207
Background: Antibody fragments have been expressed on the major coat protein of filamentous phage using a gene VIII expression system, but with low copy numbers (averaging 0.2 Fab/phage). Objectives: As a general strategy to increase copy number, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c594b32cc48468d92b024808c5bbd2a2
https://doi.org/10.1016/s1380-2933(96)00049-8
Zobrazit plný text záznamu
5
Approaches to the Design of Semisynthetic Metal-Dependent Catalytic Antibodies
Autor: Grace R. Nakayama, Peter G. Schultz
Publikováno v: Ciba Foundation Symposium 159-Catalytic Antibodies
The binding site of the Fab fragment of antibody MOPC315 was chemically modified with cyclam (1,4,8,11-tetraazacyclotetradecane) and 1,10-phenanthroline. In the presence of the metal ions cobalt(II), copper(II), gallium(III), iron(II), nickel(II), zi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e1b2413d20500de3cec7c0c6b40429
https://doi.org/10.1002/9780470514108.ch6
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje