Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Grace Png"'
Autor:
Grace Png, Andrei Barysenka, Linda Repetto, Pau Navarro, Xia Shen, Maik Pietzner, Eleanor Wheeler, Nicholas J. Wareham, Claudia Langenberg, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anders Mälarstig, James F. Wilson, Arthur Gilly, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Serum proteins are easily accessible biomarkers and drug targets. Here, the authors use whole genome sequencing data to describe the genetic architecture of neurologically-relevant serum proteins and establish causal protein-neurological disease rela
Externí odkaz:
https://doaj.org/article/2f5b2a2d19854a24b3c3f873cde81d0b
Autor:
Arthur Gilly, Lucija Klaric, Young-Chan Park, Grace Png, Andrei Barysenka, Joseph A. Marsh, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, James F. Wilson, Eleftheria Zeggini
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101509- (2022)
Objective: Deep sequencing offers unparalleled access to rare variants in human populations. Understanding their role in disease is a priority, yet prohibitive sequencing costs mean that many cohorts lack the sample size to discover these effects on
Externí odkaz:
https://doaj.org/article/15f2ee78d2c847708e47b9c89c0c5823
Autor:
Arthur Gilly, Young-Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Daniel Suveges, Sonja Neumeyer, N. William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the
Externí odkaz:
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
Linda Repetto, Jiantao Chen, Zhijian Yang, Ranran Zhai, Paul Timmers, Ting Li, Emma Twait, Sebastian May-Wilson, Marisa Muckian, Bram Prins, Grace Png, Charles Kooperberg, Åsa Johansson, Robert Hillary, Eleanor Wheeler, Lu Pan, Yazhou He, Sofia Klasson, Shahzad Ahmad, James Peters, Arthur Gilly, Maria Karaleftheri, Emmanouil Tsafantakis, Jeffrey Haessler, Ulf Gyllensten, Sarah Harris, Nicholas Wareham, Andreas Göteson, Cecilia Lagging, M. Arfan Ikram, Cornelia van Duijn, Christina Jern, Mikael Landén, Claudia Langenberg, Ian Deary, Riccardo Marioni, Stefan Enroth, Alexander Reiner, George Dedoussis, Eleftheria Zeggini, Adam Butterworth, Anders Mälarstig, James Wilson, Pau Navarro, Xia Shen
Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5712a9d93d83a89cc2d6743b7389894b
https://doi.org/10.21203/rs.3.rs-2720355/v1
https://doi.org/10.21203/rs.3.rs-2720355/v1
Autor:
Corinne Carland, Grace Png, Anders Malarstig, Pik Fang Kho, Stefan Gustafsson, Karl Michaelsson, Lars Lind, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anna Ramisch, Erin Macdonald-Dunlop, Lucija Klaric, Peter K. Joshi, Yan Chen, Hanna M. Björck, Per Eriksson, Julia Carrasco-Zanini, Eleanor Wheeler, Karsten Suhre, Arthur Gilly, Eleftheria Zeggini, Ana Viñuela, Emmanouil T. Dermitzakis, James F. Wilson, Claudia Langenberg, Gaurav Thareja, Anna Halama, Frank Schmidt, SCALLOP Consortium, Daniela Zanetti, Themistocles Assimes
Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4644e1f69a824ecf58f602bffea2d832
https://doi.org/10.21203/rs.3.rs-2621829/v1
https://doi.org/10.21203/rs.3.rs-2621829/v1
Autor:
Linda Repetto, Jiantao Chen, Zhijian Yang, Ranran Zhai, Paul R. H. J. Timmers, Ting Li, Emma L. Twait, Sebastian May-Wilson, Marisa D. Muckian, Bram P. Prins, Grace Png, Charles Kooperberg, Åsa Johansson, Robert F. Hillary, Eleanor Wheeler, Lu Pan, Yazhou He, Sofia Klasson, Shahzad Ahmad, James E. Peters, Arthur Gilly, Maria Karaleftheri, Emmanouil Tsafantakis, Jeffrey Haessler, Ulf Gyllensten, Sarah E. Harris, Nicholas J. Wareham, Andreas Göteson, Cecilia Lagging, Mohammad Arfan Ikram, Cornelia M. van Duijn, Christina Jern, Mikael Landén, Claudia Langenberg, Ian J. Deary, Riccardo E. Marioni, Stefan Enroth, Alexander P. Reiner, George Dedoussis, Eleftheria Zeggini, Adam S. Butterworth, Anders Mälarstig, James F. Wilson, Pau Navarro, Xia Shen
Publikováno v:
medRxiv
Understanding the genetic basis of neuro-related proteins is essential for dissecting the disease etiology of neuropsychiatric disorders and other complex traits and diseases. Here, the SCALLOP Consortium conducted a genome-wide association meta-anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4242375143c1b6d4308c94c338355190
https://doi.org/10.1101/2023.02.10.23285650
https://doi.org/10.1101/2023.02.10.23285650
Autor:
Grace Png, Emmanouil Tsafantakis, Iris Fischer, N. William Rayner, Daniel Suveges, George Dedoussis, Andrei Barysenka, Arthur Gilly, Sonja Neumeyer, Lorraine Southam, Thea Bjørnland, Maria Karaleftheri, Young-Chan Park, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571b46eb8d5837c975f58d0af3d41717
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
Grace Png, Raffaele Gerlini, Konstantinos Hatzikotoulas, Andrei Barysenka, N William Rayner, Lucija Klarić, Birgit Rathkolb, Juan A Aguilar-Pimentel, Jan Rozman, Helmut Fuchs, Valerie Gailus-Durner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Claus Pietrzik, James F Wilson, Martin Hrabe de Angelis, Christoph Becker-Pauly, Arthur Gilly, Eleftheria Zeggini
Publikováno v:
Hum. Mol. Genet., DOI: 10.1093/hmg/ddac275 (2022)
Png, G, Gerlini, R, Hatzikotoulas, K, Barysenka, A, Rayner, N W, Klarić, L, Rathkolb, B, Aguilar-Pimentel, J A, Rozman, J, Fuchs, H, Gailus-Durner, V, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Pietrzik, C, Wilson, J F, Angelis, M H, Becker-Pauly, C, Gilly, A & Zeggini, E 2022, ' Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac275
Png, G, Gerlini, R, Hatzikotoulas, K, Barysenka, A, Rayner, N W, Klarić, L, Rathkolb, B, Aguilar-Pimentel, J A, Rozman, J, Fuchs, H, Gailus-Durner, V, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Pietrzik, C, Wilson, J F, Angelis, M H, Becker-Pauly, C, Gilly, A & Zeggini, E 2022, ' Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac275
Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high public health burden. Understanding the genetically determined regulation of proteins that are dysregulated in disease can help to dissect the complex biology u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f316b3891f3dbb04c249127652ce7a
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66664
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66664
Autor:
Xia Shen, Eleftheria Zeggini, Eleanor Wheeler, Maik Pietzner, Andrei Barysenka, James F. Wilson, Nicholas J. Wareham, Anders Mälarstig, George Dedoussis, Linda Repetto, Maria Karaleftheri, Pau Navarro, Emmanouil Tsafantakis, Grace Png, Claudia Langenberg, Arthur Gilly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Png, G, Barysenka, A, Repetto, L, Navarro, P, Shen, X, Pietzner, M, Wheeler, E, Wareham, N J, Langenberg, C, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Mälarstig, A, Wilson, J F, Gilly, A & Zeggini, E 2021, ' Mapping the serum proteome to neurological diseases using whole genome sequencing ', Nature Communications, vol. 12, no. 1, pp. 7042 . https://doi.org/10.1038/s41467-021-27387-1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Png, G, Barysenka, A, Repetto, L, Navarro, P, Shen, X, Pietzner, M, Wheeler, E, Wareham, N J, Langenberg, C, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Mälarstig, A, Wilson, J F, Gilly, A & Zeggini, E 2021, ' Mapping the serum proteome to neurological diseases using whole genome sequencing ', Nature Communications, vol. 12, no. 1, pp. 7042 . https://doi.org/10.1038/s41467-021-27387-1
Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4fbf755cbc97a77881f70a16db2952
http://europepmc.org/articles/PMC8640022
http://europepmc.org/articles/PMC8640022
Autor:
Grace Png, Daniel Suveges, Young‐Chan Park, Klaudia Walter, Kousik Kundu, Ioanna Ntalla, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini, Arthur Gilly
Publikováno v:
Genetic Epidemiology. 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed1ed6488e812adb36adaf254d0e0d7c
https://doi.org/10.1002/gepi.22219
https://doi.org/10.1002/gepi.22219