Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Grace P. Leung"'
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic success of RAF and MEK inhibitors in treating BRAFV600-mutant tumors, a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ff887f10d18c65cb8cab29c0716d78
https://doi.org/10.1158/1541-7786.c.6541189
https://doi.org/10.1158/1541-7786.c.6541189
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
Figure S1. Cellular phenotypes observed in response to ERK2 overexpression in A-375 cells. Figure S2. No paracrine effect was produced by cells dying due to knockdown of the essential gene PSMA3. Figure S3. A-375 xenograft tumors with ERK2 overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f0971ae04461a87e039b93d72942c
https://doi.org/10.1158/1541-7786.22515802.v1
https://doi.org/10.1158/1541-7786.22515802.v1
Autor:
Juntao (Matt) Mai, Kate Caldwell, Lindsay DeVorkin, Grace P. Leung, Karine Herve, Yuri Hwang, Cristina Faralla, Wei Wei, Emma Lathouwers, Valentine de Puyraimond, Lauren Clifford, Rhys S. Chappell, Stefan Hannie, Katherine J. Lam, Harveer Dhupar, Tran N. Tran, Melissa Cid, Lena M. Bolten, Tova Pinsky, Ping Xiang, Courteney Lai, Ahn Lee, Vivian Z. Li, Patrick Chan, Jasmine Chin, Steve Booth, Amy C. Lee, Stephanie Masterman, Sherie Duncan, Aaron Yamniuk, Kush Dalal, Tim M. Jacobs, Raffi Tonikian, Bryan C. Barnhart
Publikováno v:
Cancer Research. 83:1886-1886
In this study, we describe the characterization and validation of a diverse panel of fully human CD3-binding antibodies, including hundreds of human and cyno cross-reactive binders. We used two proof-of-concept TCE targets to demonstrate that this pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47061b8b3f04aed268ae085c8e24ab8e
https://doi.org/10.1158/1538-7445.am2023-1886
https://doi.org/10.1158/1538-7445.am2023-1886
Autor:
Davide Tortora, Peter Bergqvist, Grace P. Leung, Elena Vigano, Antonios Samiotakis, Harveer Dhupar, Wei Wei, Shirley R. Zhi, Yukiko Sato, Allison Goodman, Cindy-Lee Crichlow, Melissa Cid, Jessica Fernandes Scortecci, Ping Xiang, Ahn Lee, Vivian Li, Stephanie Masterman, Sherie Duncan, Aaron Yamniuk, Kush Dalal, Tim Jacobs, Raffi Tonikian, Bryan C. Barnhart
Publikováno v:
Cancer Research. 83:1891-1891
In this study, we describe the discovery of antibodies against a MAGE-A4 peptide-major histocompatibility complex (pMHC). These antibodies will form the basis for the tumor-binding arm of T-cell engagers (TCEs) against this target. Bispecific CD3 TCE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df6ac3ba1849326fbae71771b5194ce
https://doi.org/10.1158/1538-7445.am2023-1891
https://doi.org/10.1158/1538-7445.am2023-1891
Publikováno v:
DNA Repair. 37:22-32
Cells are constantly exposed to assaults that cause DNA damage, which must be detected and repaired to prevent genome instability. The DNA damage response is mediated by key kinases that activate various signaling pathways. In Saccharomyces cerevisia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b63097218841b6e9bb4a4855f9b3581
https://doi.org/10.1016/j.dnarep.2015.10.007
https://doi.org/10.1016/j.dnarep.2015.10.007
Autor:
Tianshu Feng, Darrin Stuart, Frederic Sigoillot, Matthew D. Shirley, David A. Ruddy, Alyson K. Freeman, Jeffrey A. Engelman, Daniel P. Rakiec, Felipe Correa Geyer, Mariela Jaskelioff, Grace P. Leung
Publikováno v:
Molecular cancer research : MCR. 17(1)
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic success of RAF and MEK inhibitors in treating BRAFV600-mutant tumors, a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de2c3bad48d02e341aaabe582687780
https://pubmed.ncbi.nlm.nih.gov/30201825
https://pubmed.ncbi.nlm.nih.gov/30201825
Autor:
Frederic Sigoillot, Tianshu Feng, David A. Ruddy, Mariela Jaskelioff, Matthew D. Shirley, Alyson K. Freeman, Darrin Stuart, Grace P. Leung
Publikováno v:
Cancer Research. 78:965-965
The most frequent genetic alterations in melanoma are gain-of-function mutations in BRAF, which result in addiction to RAF-MEK-ERK signaling. Given the centrality of this pathway in many cancers, inhibitors have been developed against various nodes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c75bf9ea0f610ffc9da1194fcd7ad5c7
https://doi.org/10.1158/1538-7445.am2018-965
https://doi.org/10.1158/1538-7445.am2018-965
Genome integrity is maintained by a network of DNA damage response pathways, including checkpoints and DNA repair processes. In Saccharomyces cerevisiae, the BRCT domain-containing protein Rtt107/Esc4 is required for the restart of DNA replication af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba69ba4ac05a87d7136cf9ce77c5305
https://europepmc.org/articles/PMC3138301/
https://europepmc.org/articles/PMC3138301/
Autor:
Thorsten I. Schmidt, Nancy LévesqueN. Lévesque, Michael S. Kobor, Grace P. Leung, Alexandra K. Fok
Publikováno v:
The Journal of biological chemistry. 285(45)
Genomic integrity is maintained by the coordinated interaction of many DNA damage response pathways, including checkpoints, DNA repair processes, and cell cycle restart. In Saccharomyces cerevisiae, the BRCA1 C-terminal domain-containing protein Rtt1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39df4c651702fc92883adf92fc606827
https://pubmed.ncbi.nlm.nih.gov/20810656
https://pubmed.ncbi.nlm.nih.gov/20810656