Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Grace Mugumbate"'
Publikováno v:
Cogent Public Health, Vol 11, Iss 1 (2024)
Malaria is an infectious disease caused protozoa in genus Plasmodium. In spite of the efforts made in the fight against malaria, this tropic infectious disease is still one of the most common vector borne disease in the WHO African region. Therefore,
Externí odkaz:
https://doaj.org/article/8bb8d5c8837b42f48cbd2ae172f3537e
Publikováno v:
Cogent Public Health, Vol 11, Iss 1 (2024)
AbstractBeside the use of conventional medicines, Zimbabweans rely on native malaria control and treatment practices. This mini-review therefore seeks to identify and assess applicability of Zimbabwean indigenous practices in the fight against malari
Externí odkaz:
https://doaj.org/article/9f3643ce19a548ffa9d110c0fd34d8b2
Publikováno v:
All Life, Vol 16, Iss 1 (2023)
The survival of the malaria parasite is highly dependent on withstanding physiological stresses, which are a proportional response to parasite invasion within the hostile human host environment. Plasmodium falciparum heat shock protein 70-1 (PfHSP70-
Externí odkaz:
https://doaj.org/article/65d98cccef364bb2bf1e97025b866ded
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
Schistosomiasis, a disease usually related to poverty and poor sanitation, affects more than 200 million people worldwide. Since the 1970s, the medical sector has depended on a single drug, praziquantel, for the treatment of the disease. The emerging
Externí odkaz:
https://doaj.org/article/5138922a9b6e4d0381d889d2487ec1de
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) impedes the End TB Strategy by the World Health Organization aiming for zero deaths, disease, and suffering at the hands of tuberculosis (TB). Mutations within anti-TB drug t
Externí odkaz:
https://doaj.org/article/a4551d9909d84a74a9c907c0bcb63a1d
Autor:
Phanankosi Moyo, Grace Mugumbate, Jacobus N. Eloff, Abraham I. Louw, Vinesh J. Maharaj, Lyn-Marié Birkholtz
Publikováno v:
Pharmaceuticals, Vol 13, Iss 9, p 251 (2020)
The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but
Externí odkaz:
https://doaj.org/article/486cca23267d4006a045d1da4b069d80
Autor:
Ryman Shoko, Justen Manasa, Mcebisi Maphosa, Joshua Mbanga, Reagan Mudziwapasi, Victoria Nembaware, Walter T Sanyika, Tawanda Tinago, Zedias Chikwambi, Cephas Mawere, Alice Matimba, Grace Mugumbate, Jonathan Mufandaedza, Nicola Mulder, Hugh Patterton
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006480 (2018)
Externí odkaz:
https://doaj.org/article/3ceaaaa7766f4cfe9759053589a541df
Autor:
Grace Mugumbate, Vitor Mendes, Michal Blaszczyk, Mohamad Sabbah, George Papadatos, Joel Lelievre, Lluis Ballell, David Barros, Chris Abell, Tom L. Blundell, John P. Overington
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of liga
Externí odkaz:
https://doaj.org/article/e7b57dda8166440d852088a1b5e23b5f
Autor:
Grace Mugumbate, Katherine A Abrahams, Jonathan A G Cox, George Papadatos, Gerard van Westen, Joël Lelièvre, Szymon T Calus, Nicholas J Loman, Lluis Ballell, David Barros, John P Overington, Gurdyal S Besra
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121492 (2015)
The lack of success in target-based screening approaches to the discovery of antibacterial agents has led to reemergence of phenotypic screening as a successful approach of identifying bioactive, antibacterial compounds. A challenge though with this
Externí odkaz:
https://doaj.org/article/5de62909414341ebb0e3ccf4111f83b5
Autor:
María Jose Rebollo-Lopez, Joël Lelièvre, Daniel Alvarez-Gomez, Julia Castro-Pichel, Francisco Martínez-Jiménez, George Papadatos, Vinod Kumar, Gonzalo Colmenarejo, Grace Mugumbate, Mark Hurle, Vanessa Barroso, Rob J Young, María Martinez-Hoyos, Rubén González del Río, Robert H Bates, Eva Maria Lopez-Roman, Alfonso Mendoza-Losana, James R Brown, Emilio Alvarez-Ruiz, Marc A Marti-Renom, John P Overington, Nicholas Cammack, Lluís Ballell, David Barros-Aguire
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142293 (2015)
As a follow up to the antimycobacterial screening exercise and the release of GSK´s first Tres Cantos Antimycobacterial Set (TCAMS-TB), this paper presents the results of a second antitubercular screening effort of two hundred and fifty thousand com
Externí odkaz:
https://doaj.org/article/8e46eddd23e54015ab4639bb3308df5d