Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Grace Mallett"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2836 (2019)
Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine sec
Externí odkaz:
https://doaj.org/article/3061b0e148c14112b8e1c309da00d19a
Publikováno v:
Seminars in Cancer Biology. 86:1045-1055
Programmed cell death-1 (PD-1; CD279) is a cell surface receptor that is expressed in both innate and adaptive immune cells. The role of PD-1 in adaptive immune cells, specifically in CD8sup+/supT cells, has been thoroughly investigated but its signi
Autor:
Sorayut Chattrakarn, Grace Mallett, Helen Parker, Neus Lozano, Kostas Kostarelos, Andrew S. MacDonald
Publikováno v:
Cancer Research. 83:LB334-LB334
Introduction: Novel cancer immunotherapies are urgently needed due to a lack of definitive treatments, as well as toxicity and cost of current therapies. 2-dimensional carbon graphene oxide (GO) nanomaterials provide a large surface area, high protei
Autor:
Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom, Laura C. Greaves
Publikováno v:
Nat Cancer
Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute to tumorigenesis remains u
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2121
Innate lymphoid cells (ILCs) are important for both tissue immunity and tissue homeostasis. They are classified into three groups: Group 1 ILCs include NK cells, which are important in eliciting immunity against intracellular pathogens; group 2 ILCs
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603376
Innate lymphoid cells (ILCs) are important for both tissue immunity and tissue homeostasis. They are classified into three groups: Group 1 ILCs include NK cells, which are important in eliciting immunity against intracellular pathogens; group 2 ILCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b364064623e3c0bcec538fedd0648ae
https://doi.org/10.1007/978-1-0716-0338-3_14
https://doi.org/10.1007/978-1-0716-0338-3_14
Autor:
Emma L. Woodward, William E. Paul, Jonathan Scott, Ming-an Sun, Nathaniel Zhu, Evelyn L. Martin, Yuefeng Huang, Samuel Taylor, Nick J. Reynolds, Daniel H. Fowler, Grace Mallett, M Elias, Tania C. Felizardo, Chaido Stathopoulou, Shoba Amarnath
Publikováno v:
Journal of Experimental Medicine. 214:1663-1678
Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response to cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an impor
Autor:
Shoba Amarnath, David Knight, Michael Eckhaus, Sanders I. van Kasteren, Ethan M. Shevach, Grace Mallett, Arunakumar Gangaplara, Lukasz P. Liniany, Francis A. Flomerfelt, Laura E. Edgington-Mitchell, Tania C. Felizardo, Colin Watts, Matthew Bogyo, Jinfang Zhu, Chaido Stathopoulou, Arian Laurence, Jonathan Martinez-Fabregas, Joshua J. Yim, Daniel H. Fowler, Rolando Berlinguer-Palmini, Leigh Samsel
Publikováno v:
Immunity, 49(2), 247-263.e7
CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death-1 receptor (PD-1) signaling imparted regulatory phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df105a93b49274717ce88480111c4c6e
https://hdl.handle.net/1887/80978
https://hdl.handle.net/1887/80978
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2836 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine sec