A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT

Autor: Peter S Blair, Grace J Young, Clare Clement, Padraig Dixon, Penny Seume, Jenny Ingram, Jodi Taylor, Jeremy Horwood, Patricia J Lucas, Christie Cabral, Nick A Francis, Elizabeth Beech, Martin Gulliford, Sam Creavin, Janet A Lane, Scott Bevan, Alastair D Hay

Publikováno v: Health Technology Assessment, Vol 27, Iss 32 (2023)

Background Clinical uncertainty in primary care regarding the prognosis of children with respiratory tract infections contributes to the unnecessary use of antibiotics. Improved identification of children at low risk of future hospitalisation might r

Externí odkaz: https://doaj.org/article/ad8c805300ab4d759a22155c468acb1f

Urodynamics tests for the diagnosis and management of bladder outlet obstruction in men: the UPSTREAM non-inferiority RCT

Autor: Amanda L Lewis, Grace J Young, Lucy E Selman, Caoimhe Rice, Clare Clement, Cynthia A Ochieng, Paul Abrams, Peter S Blair, Christopher Chapple, Cathryn MA Glazener, Jeremy Horwood, John S McGrath, Sian Noble, Gordon T Taylor, J Athene Lane, Marcus J Drake

Publikováno v: Health Technology Assessment, Vol 24, Iss 42 (2020)

Background: Lower urinary tract symptoms (LUTS) in men may indicate bladder outlet obstruction (BOO) or weakness, known as detrusor underactivity (DU). Severe bothersome LUTS are a common indication for surgery. The diagnostic tests may include urody

Externí odkaz: https://doaj.org/article/a406442a1238455983bf2a8fc75bf799

Prostate Surgery for Men with Lower Urinary Tract Symptoms: Do We Need Urodynamics to Find the Right Candidates? Exploratory Findings from the UPSTREAM Trial

Autor: Grace J. Young, Chris Metcalfe, J. Athene Lane, Amanda L. Lewis, Paul Abrams, Peter S. Blair, Hiroki Ito, Christopher Chapple, Marcus J. Drake

Publikováno v: Young, G, Metcalfe, C, Lane, J A, Lewis, A L, Abrams, P, Blair, P S, Ito, H, Chapple, C & Drake, M J 2021, ' Prostate Surgery for Men with Lower Urinary Tract Symptoms: Do We Need Urodynamics to Find the Right Candidates? Exploratory Findings from the UPSTREAM Trial ', European Urology Focus . https://doi.org/10.1016/j.euf.2021.11.010

BackgroundIdentifying men whose lower urinary tract symptoms (LUTS) may benefit from surgery is challenging.ObjectiveTo identify routine diagnostic and urodynamic measures associated with treatment decision-making, and outcome, in exploratory analyse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d5bb15bda5c153fb6d8e163da70ed9
https://doi.org/10.1016/j.euf.2021.11.010

Informed consent in randomised controlled trials: development and preliminary evaluation of a measure of Participatory and Informed Consent (PIC)

Autor: Julia Wade, Daisy Elliott, Kerry N. L. Avery, Daisy Gaunt, Grace J. Young, Rebecca Barnes, Sangeetha Paramasivan, W Bruce Campbell, Jane M. Blazeby, Alison J Birtle, Rob C. Stein, David J Beard, Alison W Halliday, Jenny L. Donovan, On behalf of the ProtecT study group, CLASS study group, Chemorad study group, POUT study group, OPTIMA prelim study group, CSAW study group and ACST-2 study group

Publikováno v: Trials, Vol 18, Iss 1, Pp 1-13 (2017)

Abstract Background Informed consent (IC) is an ethical and legal prerequisite for trial participation, yet current approaches evaluating participant understanding for IC during recruitment lack consistency. No validated measure has been identified t

Externí odkaz: https://doaj.org/article/818bfc829320400da5c2e6a4e02d5319

Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation

Autor: Karen Luyt, Sally Jary, Charlotte Lea, Grace J Young, David Odd, Helen Miller, Grazyna Kmita, Cathy Williams, Peter S Blair, Aída Moure Fernández, William Hollingworth, Michelle Morgan, Adam Smith-Collins, N Jade Thai, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew Whitelaw

Publikováno v: Health Technology Assessment, Vol 23, Iss 4 (2019)

Background: The drainage, irrigation and fibrinolytic therapy (DRIFT) trial, conducted in 2003–6, showed a reduced rate of death or severe disability at 2 years in the DRIFT compared with the standard treatment group, among preterm infants with int

Externí odkaz: https://doaj.org/article/c33bc052791e4a07bd8f897e55cc4d25