Výsledky vyhledávání - "Grace G Y Lim"

Akademický článek

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

Autor: Grace G Y Lim, Katherine C M Chew, Xiao-Hui Ng, Adeline Henry-Basil, Roy W X Sim, Jeanne M M Tan, Chou Chai, Kah-Leong Lim

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73235 (2013)

Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal r

Externí odkaz: https://doaj.org/article/341b4e7893d44f2b828ee8f7401a706c

Zobrazit plný text záznamu

Akademický článek

Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.

Autor: Katherine C M Chew, Noriyuki Matsuda, Keiko Saisho, Grace G Y Lim, Chou Chai, Hui-Mei Tan, Keiji Tanaka, Kah-Leong Lim

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19720 (2011)

Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the e

Externí odkaz: https://doaj.org/article/4987a5e223204bd09706a72f5e91c936

Zobrazit plný text záznamu

Akademický článek

AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson’s Disease

Autor: Adeline H. Basil, Joan P. L. Sim, Grace G. Y. Lim, Shuping Lin, Hui Ying Chan, Simone Engelender, Kah-Leong Lim

Publikováno v: Frontiers in Cellular Neuroscience, Vol 11 (2017)

Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that

Externí odkaz: https://doaj.org/article/866310369a4545c09db1b65b6769adfe

Zobrazit plný text záznamu

Parkin‐independent mitophagy— FKBP 8 takes the stage

Autor: Kah-Leong Lim, Grace G. Y. Lim

Publikováno v: EMBO reports. 18:864-865

Mitophagy, the selective removal of damaged or excess mitochondria by autophagy, is an important process in cellular homeostasis. The outer mitochondrial membrane (OMM) proteins NIX, BNIP3, FUNDC1, and Bcl2‐L13 recruit ATG8 proteins (LC3/GABARAP) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9b861137c432ce8ad5638d674fb1e6
https://doi.org/10.15252/embr.201744313

Zobrazit plný text záznamu

Role of Autophagy in Parkinson’s Disease

Autor: Grace G. Y. Lim, Kah-Leong Lim, Chengwu Zhang

Publikováno v: Autophagy-A Double-Edged Sword-Cell Survival or Death?

Parkinson’s disease (PD) is a prevalent neurodegenerative movement disorder whose occurrence crosses geographic, racial and social boundaries affecting 1-2% of the population above the age of 65 (Dorsey et al., 2007). Clinically, the disease is att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8044648066bf34c6a8a051d5915097b
https://doi.org/10.5772/54927

Zobrazit plný text záznamu

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination

Autor: Jeanne M.M. Tan, Xiao-Hui Ng, Kah-Leong Lim, Adeline Henry-Basil, Grace G. Y. Lim, Chou Chai, Roy W. X. Sim, Katherine C. M. Chew

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e73235 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287d4d679d868d3826a9c38e3353a6f1
https://pubmed.ncbi.nlm.nih.gov/24023840

Zobrazit plný text záznamu

Parkin and Parkinson’s Disease

Autor: Grace G. Y. Lim, Calvin W.S. Yeo, Shiam-Peng Tay, Kah-Leong Lim

Publikováno v: Etiology and Pathophysiology of Parkinson's Disease

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder affecting millions of predominantly elderly individuals worldwide. Originally described as “The Shaking Palsy” in 1817 by the British physician, James Parkinson, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae48aa571f1f3ceb2897a9d6bcf9356
http://www.intechopen.com/articles/show/title/parkin-and-parkinson-s-disease

Zobrazit plný text záznamu

K63-linked ubiquitination and neurodegeneration

Autor: Kah-Leong Lim, Grace G. Y. Lim

Publikováno v: Neurobiology of Disease, Vol 43, Iss 1, Pp 9-16 (2011)

The proteasome, which identifies and destroys unwanted proteins rapidly, plays a vital role in maintaining cellular protein homeostasis. Proteins that are destined for proteasome-mediated degradation are usually tagged with a chain of ubiquitin linke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812d4242573ce9e2e712db597e27b3b1
https://pubmed.ncbi.nlm.nih.gov/20696248

Zobrazit plný text záznamu

Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

Autor: Keiko Saisho, Kah-Leong Lim, Hui-Mei Tan, Noriyuki Matsuda, Keiji Tanaka, Katherine C. M. Chew, Grace G. Y. Lim, Chou Chai

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19720 (2011)
PLoS ONE

Background Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23e378607c24afc9ce68de5a994b3b5
https://doi.org/10.1371/journal.pone.0019720

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání