A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

Autor: Md Abu Sayeed, Meagan Kelly Bufano, Peng Xu, Grace Eckhoff, Richelle C Charles, Mohammad Murshid Alam, Tania Sultana, Md Rasheduzzaman Rashu, Amanda Berger, Geoffrey Gonzalez-Escobedo, Anjali Mandlik, Taufiqur Rahman Bhuiyan, Daniel T Leung, Regina C LaRocque, Jason B Harris, Stephen B Calderwood, Firdausi Qadri, W F Vann, Pavol Kováč, Edward T Ryan

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003881 (2015)

BACKGROUND:Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY

Externí odkaz: https://doaj.org/article/0e79629c217d48a793da67a0f610ed0b

Immune Responses to the O-Specific Polysaccharide Antigen in Children Who Received a Killed Oral Cholera Vaccine Compared to Responses following Natural Cholera Infection in Bangladesh

Autor: Daniel T. Leung, Ashraf I. Khan, Mohammad Arif Rahman, Farhana Khanam, Grace Eckhoff, Ying Wu-Freeman, Edward T. Ryan, Pavol Kováč, Taher Uddin, Richelle C. Charles, Mohammad Murshid Alam, Stephen B. Calderwood, Yanan Yu, Regina C. LaRocque, Meagan Kelly Bufano, Firdausi Qadri, Russell A. Johnson, Tania Sultana, Jason B. Harris, Peng Xu, Fahima Chowdhury, Amit Saha, Amena Aktar

Publikováno v: Clinical and Vaccine Immunology. 20:780-788

Current oral cholera vaccines induce lower levels of protective efficacy and shorter durations of protection in young children than in adults. Immunity against cholera is serogroup specific, and immune responses to Vibrio cholerae lipopolysaccharide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467cc0c158e30a7532b08452b75e9960
https://doi.org/10.1128/cvi.00035-13

Molecular Analysis of Glucose-6-Phosphate Dehydrogenase Gene Mutations in Bangladeshi Individuals

Autor: Mohammod Shahidullah, Kaiissar Mannoor, Firdausi Qadri, Golam Sarower Bhuyan, Grace Eckhoff, Suprovath Kumar Sarker, Mohammad Amir Hossain, Sarabon Tahura, MA Mannan, Syeda Kashfi Qadri, Tarikul Islam, Manzoor Hussain, A. K. M. Muraduzzaman, Tahmina Shirin, Nazmun Nahar, Shahida Akhter

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166977 (2016)
PLoS ONE

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked human enzyme defect of red blood cells (RBCs). Individuals with this gene defect appear normal until exposed to oxidative stress which induces hemolysis. Consumption of certain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25595aab678bc0aaecaec7336d444af4
http://europepmc.org/articles/PMC5120827?pdf=render

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

Autor: Agnès Marchio, Jean-Pierre Vartanian, Grace Eckhoff, Pascal Pineau, Michel Henry, Anne Dejean, Denise Guetard, Rodolphe Suspène, Marie-Ming Aynaud, Simon Wain-Hobson

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (12), pp.4858-63. ⟨10.1073/pnas.1009687108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (12), pp.4858-63. ⟨10.1073/pnas.1009687108⟩

The human APOBEC3 ( A3A–A3H ) locus encodes six cytidine deaminases that edit single-stranded DNA, the result being DNA peppered with uridine. Although several cytidine deaminases are clearly restriction factors for retroviruses and hepadnaviruses,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120cd6da0022157591860368d6220477
https://hal-pasteur.archives-ouvertes.fr/pasteur-00591073