Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Grace E Lidgerwood"'
Autor:
Jenna Hall, Maciej Daniszewski, Shane Cheung, Kalyan Shobhana, Himeesh Kumar, Helena H Liang, Henry Beetham, Ellie Cho, Carla Abbott, Alex W Hewitt, Kaylene J Simpson, Robyn H Guymer, Daniel Paull, Alice Pébay, Grace E. Lidgerwood
Publikováno v:
SLAS Technology, Vol 29, Iss 3, Pp 100106- (2024)
Age-Related Macular Degeneration (AMD) is a highly prevalent form of retinal disease amongst Western communities over 50 years of age. A hallmark of AMD pathogenesis is the accumulation of drusen underneath the retinal pigment epithelium (RPE), a bio
Externí odkaz:
https://doaj.org/article/4a7f9281b8ca4b939616a31e76f62cde
Autor:
Adrian Westhaus, Steven S. Eamegdool, Milan Fernando, Paula Fuller-Carter, Alicia A. Brunet, Annie L. Miller, Rabab Rashwan, Maddison Knight, Maciej Daniszewski, Grace E. Lidgerwood, Alice Pébay, Alex Hewitt, Giorgia Santilli, Adrian J. Thrasher, Livia S. Carvalho, Anai Gonzalez-Cordero, Robyn V. Jamieson, Leszek Lisowski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Adeno-associated viral (AAV) vector-mediated retinal gene therapy is an active field of both pre-clinical as well as clinical research. As with other gene therapy clinical targets, novel bioengineered AAV variants developed by directed evolu
Externí odkaz:
https://doaj.org/article/c01c7ea263f948d68832145c2e5bdb19
Autor:
Drew R. Neavin, Angela M. Steinmann, Nona Farbehi, Han Sheng Chiu, Maciej S. Daniszewski, Himanshi Arora, Yasmin Bermudez, Cátia Moutinho, Chia-Ling Chan, Monique Bax, Mubarika Tyebally, Vikkitharan Gnanasambandapillai, Chuan E. Lam, Uyen Nguyen, Damián Hernández, Grace E. Lidgerwood, Robert M. Graham, Alex W. Hewitt, Alice Pébay, Nathan J. Palpant, Joseph E. Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suit
Externí odkaz:
https://doaj.org/article/499bbef94bc84c94a2ef1a7bf2ddfd93
Autor:
Anne Senabouth, Maciej Daniszewski, Grace E. Lidgerwood, Helena H. Liang, Damián Hernández, Mehdi Mirzaei, Stacey N. Keenan, Ran Zhang, Xikun Han, Drew Neavin, Louise Rooney, Maria Isabel G. Lopez Sanchez, Lerna Gulluyan, Joao A. Paulo, Linda Clarke, Lisa S. Kearns, Vikkitharan Gnanasambandapillai, Chia-Ling Chan, Uyen Nguyen, Angela M. Steinmann, Rachael A. McCloy, Nona Farbehi, Vivek K. Gupta, David A. Mackey, Guy Bylsma, Nitin Verma, Stuart MacGregor, Matthew J. Watt, Robyn H. Guymer, Joseph E. Powell, Alex W. Hewitt, Alice Pébay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derive
Externí odkaz:
https://doaj.org/article/26ee70153c844e808b5ef6d67e2ac7a9
Autor:
Jiang-Hui Wang, Grace E. Lidgerwood, Maciej Daniszewski, Monica L. Hu, Georgina E. Roberts, Raymond C. B. Wong, Sandy S. C. Hung, Michelle E. McClements, Alex W. Hewitt, Alice Pébay, Doron G. Hickey, Thomas L. Edwards
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Bietti crystalline dystrophy (BCD) is an inherited retinal disease (IRD) caused by mutations in the CYP4V2 gene. It is a relatively common cause of IRD in east Asia. A number of features of this disease make it highly amenable to gene supple
Externí odkaz:
https://doaj.org/article/92f20941b1a14782b8b22261c0464675
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time
Autor:
Grace E. Lidgerwood, Anne Senabouth, Casey J.A. Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C. Kaczorowski, Daniela Amann-Zalcenstein, Erica L. Fletcher, Shalin H. Naik, Alex W. Hewitt, Joseph E. Powell, Alice Pébay
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 223-242 (2021)
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accurate modelling of diseases associated with maturity or age. Hence, it is important to characterise how closely cells use
Externí odkaz:
https://doaj.org/article/a1b752ada11e4c119fcf167e7656b297
Autor:
Drew Neavin, Quan Nguyen, Maciej S. Daniszewski, Helena H. Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, James C. Vickers, Anthony L. Cook, Nathan J. Palpant, Alice Pébay, Alex W. Hewitt, Joseph E. Powell
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies. Gene expression plays
Externí odkaz:
https://doaj.org/article/d89867322e804dd0acd2dc0180fe5fe8
Autor:
Maciej Daniszewski, Anne Senabouth, Helena H. Liang, Xikun Han, Grace E. Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E. Clarke, Shiang Y. Lim, Jarmon G. Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L. Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A. McCloy, Linda Clarke, Lisa S. Kearns, David A. Mackey, Jamie E. Craig, Stuart MacGregor, Joseph E. Powell, Alice Pébay, Alex W. Hewitt
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100142- (2022)
Summary: To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retin
Externí odkaz:
https://doaj.org/article/bda5107c7c8a45e0aa69bcd697f93428
Autor:
Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline K. R. Walker, Grace E. Lidgerwood, Kimberley L. Dilworth, Leszek Lisowski, Alice Pébay, Alex W. Hewitt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Off-target effects and the feasibility for AAV-mediated delivery are the major barriers impeding the clinical in vivo application of base editors. Here, the authors report the small size AAV-deliverable Cas9-ABE variant that has improved on-target ed
Externí odkaz:
https://doaj.org/article/e11fbcac1a274b3aa056ddd2fd2f8176
Autor:
Maciej Daniszewski, Quan Nguyen, Hun S. Chy, Vikrant Singh, Duncan E. Crombie, Tejal Kulkarni, Helena H. Liang, Priyadharshini Sivakumaran, Grace E. Lidgerwood, Damián Hernández, Alison Conquest, Louise A. Rooney, Sophie Chevalier, Stacey B. Andersen, Anne Senabouth, James C. Vickers, David A. Mackey, Jamie E. Craig, Andrew L. Laslett, Alex W. Hewitt, Joseph E. Powell, Alice Pébay
Publikováno v:
iScience, Vol 7, Iss , Pp 30-39 (2018)
Summary: We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex and TeSR-E8 media. Analysis of transcriptome of single cells revealed similar expression of core pluripotency gen
Externí odkaz:
https://doaj.org/article/7a57b9886f4c465e9568b2e61af1aab8