Výsledky vyhledávání - "Grace C. O'Regan"

Akademický článek

Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

Autor: Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph Andre

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)

Abstract Background Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset

Externí odkaz: https://doaj.org/article/e73b03f2b0fe4371bf25bcd8a40ef24b

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Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

Autor: Sarah J. Tabrizi, Grace C. O’Regan, Alison Wood-Kaczmar, Jennifer M. Pocock, Sahar Farag, Ralph Andre, Caroline Casey

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Journal of Neuroinflammation

Background Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6249c91804a3c2ed8f9b83b26e799fd
https://doi.org/10.1186/s12974-021-02147-6

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Wild-type huntingtin regulates human macrophage function

Autor: Sahar Farag, Sarah J. Tabrizi, Grace C. O’Regan, Ralph Andre, Gary R. Ostroff

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

The huntingtin (HTT) protein in its mutant form is the cause of the inherited neurodegenerative disorder, Huntington’s disease. Beyond its effects in the central nervous system, disease-associated mutant HTT causes aberrant phenotypes in myeloid-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8378e6b9109fb077dce4078d001b4bad
https://doi.org/10.1038/s41598-020-74042-8

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Glucocerebrosidase Mutations in Parkinson Disease

Autor: Anthony H.V. Schapira, Grace C. O’Regan, Roberta Balestrino, Ruth-Mary deSouza

Publikováno v: Journal of Parkinson's Disease. 7:411-422

Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) gene, which encodes a lysosomal enzyme involved in sphingolipid degradat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbb89cdb6910802e5e1d6f860306792
https://doi.org/10.3233/jpd-171092

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A30 The role of huntingtin in human myeloid cells

Autor: Grace C. O’Regan, Sarah J. Tabrizi, Paul Lavender, Sahar Farag, Ralph Andre

Publikováno v: Pathogenic mechanisms.

Background While the central nervous system is considered to be the primary site of Huntington’s disease pathology, the systemic innate immune system may be a modifier of disease progression. Myeloid cells from Huntington’s disease patients exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69918c3d7fab4bee315027f1ad788a8e
https://doi.org/10.1136/jnnp-2018-ehdn.28

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