The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

Autor: Grace C. Limandjaja, Frank B. Niessen, Rik J. Scheper, Susan Gibbs

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Keloids constitute an abnormal fibroproliferative wound healing response in which raised scar tissue grows excessively and invasively beyond the original wound borders. This review provides a comprehensive overview of several important themes in kelo

Externí odkaz: https://doaj.org/article/b7f9eb9d099b4a328c13e1c130025109

Hypertrophic and keloid scars fail to progress from the CD 34 − /α‐smooth muscle actin (α‐ SMA ) + immature scar phenotype and show gradient differences in α‐ SMA and p16 expression

Autor: R.J. Scheper, Grace C. Limandjaja, J.M. Belien, Susan Gibbs, Frank B. Niessen

Publikováno v: British Journal of Dermatology. 182:974-986

Background: Our understanding of the pathogenesis underlying keloid scar formation is still very limited, and the morphological distinction between hypertrophic and keloid scars remains difficult. Objectives: To test whether hypertrophic and keloid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9e7a3b38c9cb2e6a635405bd7864f99
https://doi.org/10.1111/bjd.18219

Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars

Autor: Rik J. Scheper, Susan Gibbs, Grace C. Limandjaja, Frank B. Niessen

Publikováno v: Experimental Dermatology
Limandjaja, G C, Niessen, F B, Scheper, R J & Gibbs, S 2021, ' Hypertrophic scars and keloids : Overview of the evidence and practical guide for differentiating between these abnormal scars ', Experimental Dermatology, vol. 30, no. 1, pp. 146-161 . https://doi.org/10.1111/exd.14121, https://doi.org/10.1111/exd.14121
Limandjaja, G C, Niessen, F B, Scheper, R J & Gibbs, S 2021, ' Hypertrophic scars and keloids : Overview of the evidence and practical guide for differentiating between these abnormal scars ', Experimental Dermatology, vol. 30, no. 1, pp. 146-161 . https://doi.org/10.1111/exd.14121

© 2020 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.Although hypertrophic scars and keloids both generate excessive scar tissue, keloids are characterized by their extensive growth beyond the borders of the original wound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f9b51cd72b33e54ae095efd3e8d7fc
https://pubmed.ncbi.nlm.nih.gov/32479693

Increased epidermal thickness and abnormal epidermal differentiation in keloid scars

Autor: L. J. van den Broek, R.J. Scheper, Grace C. Limandjaja, Susan Gibbs, Vincent Everts, H. A. van Veen, Stan Monstrey, Frank B. Niessen, Taco Waaijman

Publikováno v: British journal of dermatology, 176(1), 116-126. Wiley-Blackwell
BRITISH JOURNAL OF DERMATOLOGY
British Journal of Dermatology, 176(1), 116-126. Wiley-Blackwell
Limandjaja, G C, van den Broek, L J, Waaijman, T, van Veen, H A, Everts, V, Monstrey, S, Scheper, R J, Niessen, F B & Gibbs, S 2017, ' Increased epidermal thickness and abnormal epidermal differentiation in keloid scars ', British Journal of Dermatology, vol. 176, no. 1, pp. 116-126 . https://doi.org/10.1111/bjd.14844

Background: The pathogenesis underlying keloid formation is still poorly understood. Research has focused mostly on dermal abnormalities, while the epidermis has not yet been studied. Objectives: To identify differences within the epidermis of mature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b62386d2d0cec82d6dbda816d8bd0f
https://doi.org/10.1111/bjd.14844

Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models

Autor: Susan Gibbs, Rik J. Scheper, Frank B. Niessen, Edith M de Boer, Melanie Breetveld, Lenie J van den Broek, Taco Waaijman, Stan Monstrey, Grace C. Limandjaja

Publikováno v: Tissue Engineering-Part C: Methods, 24(4), 242-253. Mary Ann Liebert Inc.
Tissue Engineering. Part C, Methods, 24(4), 242-253. Mary Ann Liebert Inc.
Limandjaja, G C, van den Broek, L J, Breetveld, M, Waaijman, T, Monstrey, S, de Boer, E M, Scheper, R J, Niessen, F B & Gibbs, S 2018, ' Characterization of in vitro reconstructed human normotrophic, hypertrophic, and keloid scar models ', Tissue Engineering. Part C, Methods, vol. 24, no. 4, pp. 242-253 . https://doi.org/10.1089/ten.tec.2017.0464
Limandjaja, G C, van den Broek, L J, Breetveld, M, Waaijman, T, Monstrey, S, de Boer, E M, Scheper, R J, Niessen, F B & Gibbs, S 2018, ' Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models ', Tissue Engineering-Part C: Methods, vol. 24, no. 4, pp. 242-253 . https://doi.org/10.1089/ten.tec.2017.0464

To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required, which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feed1123f1768426dd70467474f1c70f
https://research.vumc.nl/en/publications/96fcd2f8-2aa6-4e55-bd71-69f455535541