The importance of investigating the impact of simultaneous anthropogenic stressors: the effects of rising temperatures and anthropogenic noise on avian behaviour and cognition

Autor: Grace Blackburn, Camilla Soravia, Amanda R. Ridley

Publikováno v: Journal of Avian Biology, Vol 2024, Iss 11-12, Pp n/a-n/a (2024)

Rising temperatures and anthropogenic noise are two of the most pervasive and well researched anthropogenic stressors affecting avian species globally. Despite often triggering similar behavioural responses in birds, and frequently co‐occurring (pa

Externí odkaz: https://doaj.org/article/7a370182f6624860981a2a075f77439e

An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis

Autor: Daniel J. Leite, Anna Schönauer, Grace Blakeley, Amber Harper, Helena Garcia-Castro, Luis Baudouin-Gonzalez, Ruixun Wang, Naïra Sarkis, Alexander Günther Nikola, Venkata Sai Poojitha Koka, Nathan J. Kenny, Natascha Turetzek, Matthias Pechmann, Jordi Solana, Alistair P. McGregor

Publikováno v: EvoDevo, Vol 15, Iss 1, Pp 1-23 (2024)

Abstract Spiders are a diverse order of chelicerates that diverged from other arthropods over 500 million years ago. Research on spider embryogenesis, particularly studies using the common house spider Parasteatoda tepidariorum, has made important co

Externí odkaz: https://doaj.org/article/19ef6a966ae741cdac50bae49383e81f

Machine learning to predict early recurrence after oesophageal cancer surgery

Autor: Rahman, SA, Walker, RC, Lloyd, MA, Grace, BL, Van Boxel, GI, Kingma, BF, Ruurda, JP, Van Hillegersberg, R, Harris, S, Parsons, S, Mercer, S, Griffiths, EA, O'Neill, Turkington, R, Fitzgerald, RC, Underwood, TJ, OCCAMS Consortium

BACKGROUND: Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20-30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing models perform poorly. This s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34dab7a6aa5f4c1b5ec95e1bd7de3b07

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Autor: Mourikis, TP, Benedetti, L, Foxall, E, Temelkovski, D, Nulsen, J, Perner, J, Cereda, M, Lagergren, J, Howell, M, Yau, C, Fitzgerald, RC, Scaffidi, P, Noorani, A, Edwards, PAW, Elliott, RF, Grehan, N, Nutzinger, B, Hughes, C, Fidziukiewicz, E, Bornschein, J, MacRae, S, Crawte, J, Northrop, A, Contino, G, Li, X, De la Rue, R, Katz-Summercorn, A, Abbas, S, Loureda, D, O'Donovan, M, Miremadi, A, Malhotra, S, Tripathi, M, Tavare, S, Lynch, AG, Eldridge, M, Secrier, M, Bower, L, Devonshire, G, Jammula, S, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Moorthy, K, Grabowska, A, Turkington, R, McManus, D, Khoo, D, Fickling, W, Ciccarelli, FD

The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::56bbcb4834a826025994807c5a97eb9d
https://www.repository.cam.ac.uk/handle/1810/307928

The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic

Autor: Frankell, AM, Jammula, S, Li, X, Contino, G, Killcoyne, S, Abbas, S, Perner, J, Bower, L, Devonshire, G, Cocks, E, Grehan, N, Mok, J, O'Donovan, M, MacRae, S, Eldridge, MD, Tavare, S, Fitzgerald, RC, Noorani, A, Edwards, PAW, Grehanl, N, Nutzinger, B, Hughes, CI, Fidziukiewicz, E, Northrop, A, De la Rue, R, Katz-Summercorn, A, Loureda, D, Miremadi, A, Malhotra, S, Tripathi, M, Lynch, AG, Eldridge, M, Secrier, M, Davies, J, Crichton, C, Carro, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, ONeill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, T, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Moorthy, K, Peters, CJ, Grabowska, A, Turkington, R, McManus, D, Coleman, H, Khoo, D, Fickling, W

Publikováno v: Nature genetics

Esophageal Adenocarcinoma (EAC) is a poor prognosis cancer type with rapidly rising incidence. Our understanding of genetic events which drive EAC development is limited and there are few molecular biomarkers for prognostication or therapeutics. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99929338d90f78f1c05cc30099825dcb
https://doi.org/10.1101/310029