Tunable genetic devices through simultaneous control of transcription and translation

Autor: Vittorio Bartoli, Grace A. Meaker, Mario di Bernardo, Thomas E. Gorochowski

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Synthetic genetic circuits are sensitive to their environment and host cell, requiring many rounds of physical reassembly to achieve a desired function. Here the authors use a multi-level regulatory motif to dynamically tune the function of genetic p

Externí odkaz: https://doaj.org/article/3c64e96ed5e9493bac7f1b5bff3219ee

Tunable genetic devices through simultaneous control of transcription and translation

Autor: Grace A. Meaker, Thomas E. Gorochowski, Vittorio Bartoli, Mario di Bernardo

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Bartoli, V, Meaker, G, Di Bernardo, M & Gorochowski, T E 2020, ' Tunable genetic devices through simultaneous control of transcription and translation ', Nature Communications, vol. 11, 2095 (2020) . https://doi.org/10.1038/s41467-020-15653-7

Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66856b4211700c34215a4281538d183e
http://link.springer.com/article/10.1038/s41467-020-15653-7