Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease.

Autor: Michael J Satlin, Parag Goyal, Reed Magleby, Grace A Maldarelli, Khanh Pham, Maiko Kondo, Edward J Schenck, Hanna Rennert, Lars F Westblade, Justin J Choi, Monika M Safford, Roy M Gulick

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236778 (2020)

BackgroundSevere acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are

Externí odkaz: https://doaj.org/article/9980e9019ae94b4c936e6671946e2a70

Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male

Autor: Grace A Maldarelli, Joshua A. Lieberman, Matthew S. Simon, Khanh Pham, Alex Trzebucki, Babacar Cisse, David J. Pisapia, Lee Gottesdiener, Elliot DeHaan

Publikováno v: Open Forum Infectious Diseases

We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebe3dba301cebac34f71a7e796ee40d
https://doi.org/10.1093/ofid/ofab455

Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute

Autor: Grace A, Maldarelli, Hanover, Matz, Si, Gao, Kevin, Chen, Therwa, Hamza, Harris G, Yfantis, Hanping, Feng, Michael S, Donnenberg

Publikováno v: Journal of vaccines & vaccination

Clostridium difficile is the leading cause of nosocomial infections in the United States, adding billions of dollars per year to health care costs. A vaccine targeted against the bacterium would be extremely beneficial in decreasing the morbidity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::484700479d0d763bb14cff59a40561d2
https://pubmed.ncbi.nlm.nih.gov/27375958

Virtual Lab Demonstrations Improve Students’ Mastery of Basic Biology Laboratory Techniques

Autor: Erica M. Hartmann, Patrick J. Cummings, Grace A Maldarelli, Kristina M. Obom, Richard Shingles, Robert D Horner, Rebecca Pearlman

Publikováno v: Journal of Microbiology & Biology Education, Vol 10, Iss 1, Pp 51-57 (2009)
Journal of Microbiology & Biology Education, Vol 10, Iss 1 (2009)

Biology laboratory classes are designed to teach concepts and techniques through experiential learning. Students who have never performed a technique must be guided through the process, which is often difficult to standardize across multiple lab sect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bdf4206ff71ba4e301707cc9bc4dc2
https://journals.asm.org/doi/10.1128/jmbe.v10.99

Type IV pili promote early biofilm formation by Clostridium difficile

Autor: Grace A. Maldarelli, Robert K. Ernst, Alison J. Scott, Yang Song, Erik C. von Rosenvinge, Yvonne Achermann, Jeffrey A. Freiberg, Kurt H. Piepenbrink, Mark E. Shirtliff, Eric J. Sundberg, Michael S. Donnenberg

Publikováno v: Pathogens and Disease
Pathogens and disease

Increasing morbidity and mortality from Clostridium difficile infection (CDI) present an enormous challenge to healthcare systems. Clostridium difficile express type IV pili (T4P), but their function remains unclear. Many chronic and recurrent bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a001dec911a39a9b3b534fe21b4ba46