Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Grace A, Blair"'
Autor:
Joyce Lin, Anand Abraham, Sharon A. George, Amara Greer-Short, Grace A. Blair, Angel Moreno, Bridget R. Alber, Matthew W. Kay, Steven Poelzing
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Many cardiac pathologies are associated with reduced gap junction (GJ) coupling, an important modulator of cardiac conduction velocity (CV). However, the relationship between phenotype and functional expression of the connexin GJ family of proteins i
Externí odkaz:
https://doaj.org/article/b2e5d7cd1ef94b7482db1960752450e2
Autor:
William P. Adams, Tristan B. Raisch, Yajun Zhao, Rafael Davalos, Sarah Barrett, D. Ryan King, Chandra B. Bain, Katrina Colucci-Chang, Grace A. Blair, Alexandra Hanlon, Alicia Lozano, Rengasayee Veeraraghavan, Xiaoping Wan, Isabelle Deschenes, James W. Smyth, Gregory S. Hoeker, Robert G. Gourdie, Steven Poelzing
RationaleCardiac conduction is understood to occur through gap junctions. Recent evidence supports ephaptic coupling as another mechanism of electrical communication in heart. Conduction via gap junctions predicts a direct relationship between conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac8fb30b71eac4d9631495700813a9c
https://doi.org/10.1101/2023.05.25.542366
https://doi.org/10.1101/2023.05.25.542366
Autor:
Seth H. Weinberg, Gregory S. Hoeker, D. Ryan King, Steven Poelzing, Grace A. Blair, Xiaobo Wu, Robert G. Gourdie
Publikováno v:
Am J Physiol Heart Circ Physiol
Cardiac voltage-gated sodium channel gain-of-function prolongs repolarization in the long-QT syndrome type 3 (LQT3). Previous studies suggest that narrowing the perinexus within the intercalated disc, leading to rapid sodium depletion, attenuates LQT
Autor:
Rachel L. Padget, Grace A. Blair, Michael D. North, Michael J. Zeitz, Mira T. Tanenbaum, D. Ryan King, Gregory S. Hoeker, Sharon A. Swanger, Steven Poelzing, James W. Smyth
Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic understanding. Myocarditis is a leading cause of sudden cardiac dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7ea028652244936366569a5bca86a4
https://doi.org/10.1101/2022.11.29.518421
https://doi.org/10.1101/2022.11.29.518421
Autor:
Joyce, Lin, Anand, Abraham, Sharon A, George, Amara, Greer-Short, Grace A, Blair, Angel, Moreno, Bridget R, Alber, Matthew W, Kay, Steven, Poelzing
Publikováno v:
Frontiers in Physiology. 13
Many cardiac pathologies are associated with reduced gap junction (GJ) coupling, an important modulator of cardiac conduction velocity (CV). However, the relationship between phenotype and functional expression of the connexin GJ family of proteins i
Autor:
Rachel L. Padget, Grace A. Blair, Michael D. North, D. Ryan King, Michael J. Zeitz, Mira N. Tanenbaum, Gregory S. Hoeker, Sharon A. Swanger, Steven Poelzing, James W. Smyth
Publikováno v:
The FASEB Journal. 36
Autor:
D. Ryan King, Joyce Lin, Michael Entz, Grace A. Blair, Ian Crandell, Gregory S. Hoeker, Steven Poelzing, Alexandra L. Hanlon
Publikováno v:
Pflugers Archiv
Abstract The relationship between cardiac conduction velocity (CV) and extracellular potassium (K+) is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV. Recent studies from our group suggest that elevating extracell
Autor:
Rachel Lee Padget, Grace A. Blair, Michael D. North, David R. King, Michael Zeitz, Gregory S. Hoeker, Sharon Swanger, Steven Poelzing, James W. Smyth
Publikováno v:
Heart Rhythm. 19:S32
Autor:
D King, Steven Poelzing, Michael Entz, Ian Crandell, Joyce Lin, Grace A. Blair, Alexandra L. Hanlon, Gregory S. Hoeker
Publikováno v:
Circulation. 142
Background: Previous studies have demonstrated a biphasic relationship between extracellular potassium (K o ) and cardiac conduction velocity (CV). With moderate hyperkalemia, CV increases in what is referred to as supernormal conduction, but further
Autor:
Grace A. Blair, Katrina Colucci Chang, Alexandra L. Hanlon, Steven Poelzing, Alicia J. Lozano, Xiaobo Wu
Publikováno v:
Circulation. 142
Excitability in cardiomyocytes is dependent on the subthreshold current required to raise transmembrane potential to the activation threshold of voltage gated sodium channels and sodium channel recruitment to trigger an action potential. Cardiac sodi