Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Grace Patlewicz"'
Autor:
Richard S. Judson, Doris Smith, Michael DeVito, John F. Wambaugh, Barbara A. Wetmore, Katie Paul Friedman, Grace Patlewicz, Russell S. Thomas, Risa R. Sayre, Jennifer H. Olker, Sigmund Degitz, Stephanie Padilla, Joshua A. Harrill, Timothy Shafer, Kelly E. Carstens
Publikováno v:
Toxics, Vol 12, Iss 4, p 271 (2024)
Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, c
Externí odkaz:
https://doaj.org/article/65a7eaa4eb3848ff8e5cf8a509a96a88
Autor:
Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau, John F. Wambaugh
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Understanding the metabolic fate of a xenobiotic substance can help inform its potential health risks and allow for the identification of signature metabolites associated with exposure. The need to characterize metabolites of poorly studied or novel
Externí odkaz:
https://doaj.org/article/7f0aa8ed5d56429591182f917881d06c
Autor:
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard an
Externí odkaz:
https://doaj.org/article/c77f706ac85c49c3bc5d018511b024a1
Autor:
Jessica Ponder, Ramya Rajagopal, Madhuri Singal, Nancy Baker, Grace Patlewicz, Erwin Roggen, Stella Cochrane, Kristie Sullivan
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Despite decades of investigation, test methods to identify respiratory sensitizers remain an unmet regulatory need. In order to support the evaluation of New Approach Methodologies in development, we sought to establish a reference set of low molecul
Externí odkaz:
https://doaj.org/article/46e3e9bca49c46d8ba034f5b75ba15c2
Autor:
Kyle Roell, Lauren E. Koval, Rebecca Boyles, Grace Patlewicz, Caroline Ring, Cynthia V. Rider, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Rebecca C. Fry, Julia E. Rager
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Research in environmental health is becoming increasingly reliant upon data science and computational methods that can more efficiently extract information from complex datasets. Data science and computational methods can be leveraged to better ident
Externí odkaz:
https://doaj.org/article/1eb5b45b3f9746218e2f2940b506c6cc
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/0cdf25fd603e4227b58d1ab6f2e25867
Autor:
Antony J. Williams, Linda G. T. Gaines, Christopher M. Grulke, Charles N. Lowe, Gabriel F. B. Sinclair, Vicente Samano, Inthirany Thillainadarajah, Bryan Meyer, Grace Patlewicz, Ann M. Richard
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxi
Externí odkaz:
https://doaj.org/article/0f8233458e964425b30820cff28ce2d4
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
Perfluorooctanoic acid (PFOA) and related compounds are per- and polyfluorinated alkyl substances (PFASs) of concern from toxicological, environmental, and regulatory perspectives. In 2019, the Conference of the Parties to the Stockholm Convention on
Externí odkaz:
https://doaj.org/article/49466025a54a4a7397bd6e05c3451aff
Autor:
Erin M. Maloney, Daniel L. Villeneuve, Kathleen M. Jensen, Brett R. Blackwell, Michael D. Kahl, Shane T. Poole, Kelsey Vitense, David J. Feifarek, Grace Patlewicz, Kendra Dean, Charlene Tilton, Eric C. Randolph, Jenna E. Cavallin, Carlie A. LaLone, Donovan Blatz, Christopher M. Schaupp, Gerald T. Ankley
Publikováno v:
Environmental Toxicology and Chemistry. 42:1229-1256
Publikováno v:
Computational toxicology (Amsterdam, Netherlands). 24
The Threshold of Toxicological Concern (TTC) is a pragmatic approach used to establish safe thresholds below which there can be no appreciable risk to human health. Here, a large inventory of ~45,000 substances (referred to as the LRI dataset) was pr