Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Grace, Kaul"'
Autor:
Apurva Panjla, Grace Kaul, Manjulika Shukla, Abdul Akhir, Sarita Tripathi, Ashish Arora, Sidharth Chopra, Sandeep Verma
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116810- (2024)
Globally, infections due to multi-drug resistant (MDR) Gram-negative bacterial (GNB) pathogens are on the rise, negatively impacting morbidity and mortality, necessitating urgent treatment alternatives. Herein, we report a detailed bio-evaluation of
Externí odkaz:
https://doaj.org/article/7a065d99dbf34af1903a7a30b2c7eaf3
Autor:
Grace Kaul, Abdul Akhir, Manjulika Shukla, Hasham Shafi, Ravikumar Akunuri, Gaurav Pawar, Mahammad Ghouse, Nanduri Srinivas, Sidharth Chopra
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Amid the mounting burden of multidrug-resistant (MDR) bacterial infections on health care worldwide, drug repurposing, a time and cost-effective strategy to identify new applications for drugs approved for other indications, can effectively
Externí odkaz:
https://doaj.org/article/99fea40cfddf47b598bf381f73caa6b2
Autor:
Neethu Sivadas, Grace Kaul, Abdul Akhir, Manjulika Shukla, Murugan Govindakurup Govind, Mathew Dan, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra
Publikováno v:
Antibiotics, Vol 12, Iss 10, p 1483 (2023)
The emergence of multidrug-resistant (MDR) superbugs underlines the urgent need for innovative treatment options to tackle resistant bacterial infections. The clinical efficacy of natural products directed our efforts towards developing new antibacte
Externí odkaz:
https://doaj.org/article/7f51a547315f4bf0b191348e835ce17d
Autor:
Mandeep Kaur, Ritesh Thakare, Arindom Bhattacherya, Prem Anand Murugan, Grace Kaul, Manjulika Shukla, Alok Kr. Singh, Saravanan Matheshwaran, Sidharth Chopra, Jitendra K. Bera
Publikováno v:
Dalton Transactions. 52:1876-1884
A newly designed Pt(ii)–NHC complex shows potent activity against the Gram-positive S. aureus pathogen. Further investigation reveals biofilm inhibition, in vivo activity inside mammalian cells, and combinatorial antimicrobial activity with FDA-app
Autor:
Atreyee Mishra, Karrera Y. Djoko, Yi-Hsuan Lee, Rianne M. Lord, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Sidharth Chopra, James W. Walton
Publikováno v:
Organic & Biomolecular Chemistry, 2023, Vol.21(12), pp.2539-2544 [Peer Reviewed Journal]
Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione cop
Autor:
DRGKoppalu R. Puneeth Kumar, Rahi M. Reja, Dillip K. Senapati, Manjeet Singh, Sachin A. Nalawade, Gijo George, Grace Kaul, Abdul Akhir, Sidharth Chopra, Srinivasarao Raghothama, Hosahudya N. Gopi
Publikováno v:
RSC Medicinal Chemistry. 14:332-340
A cationic amphiphilic peptide effectively prevents the aggregation of soluble Aβ42 and also disintegrates matured fibrils into soluble precursors. In addition, the peptide also rescues cells from the toxicity of Aβ42.
Autor:
Grace Kaul, Uttam B Karale, Abdul Akhir, Manjulika Shukla, Deepanshi Saxena, Haridas B Rode, Sidharth Chopra
Publikováno v:
Future Microbiology. 17:1475-1486
Background: Drug repurposing is a viable approach to expediting the tedious conventional drug discovery process, given rapidly increasing bacterial resistance. In this context, we have repurposed pyrvinium pamoate (PP) for its antibacterial activity
Autor:
Ramulu Parupalli, Ravikumar Akunuri, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Shaik Mahammad Ghouse, Venkata Madhavi Yaddanapudi, Sidharth Chopra, Srinivas Nanduri
Publikováno v:
Future Medicinal Chemistry. 14:1621-1634
Background: In the authors' previous study, 4-(2-((3-methyl-4-oxo-2-thioxo/dioxothiazolidin-5-ylidene) methyl) hydrazineyl) benzonitriles were found to demonstrate potent antibacterial activity against Acinetobacter baumannii. Interestingly, the afor
Autor:
Apurva Panjla, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Saurabh Joshi, Chandrima Modak, Dipti Kumari, Alok Jain, Sidharth Chopra, Sandeep Verma
Publikováno v:
Chemistry – An Asian Journal. 18
Autor:
Pooja Kumari, Grace Kaul, T. Anand Kumar, Abdul Akhir, Manjulika Shukla, Suraj Sharma, Siddhesh S. Kamat, Sidharth Chopra, Harinath Chakrapani
Publikováno v:
Microbiology Spectrum. 11
Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination