Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Grażyna Niewiadomska"'
Autor:
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110955- (2024)
In clinical trials for Alzheimer’s disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as m
Externí odkaz:
https://doaj.org/article/55dcde6ffee8464392a774ea753330c1
Autor:
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska
Publikováno v:
Cells, Vol 13, Iss 7, p 642 (2024)
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the
Externí odkaz:
https://doaj.org/article/08f2654462fb4a6f97b2a4c2ca2ac9d8
Autor:
Anna Gasiorowska, Malgorzata Wydrych, Patrycja Drapich, Maciej Zadrozny, Marta Steczkowska, Wiktor Niewiadomski, Grazyna Niewiadomska
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The elderly population is growing worldwide, with important health and socioeconomic implications. Clinical and experimental studies on aging have uncovered numerous changes in the brain, such as decreased neurogenesis, increased synaptic defects, gr
Externí odkaz:
https://doaj.org/article/15cf23004a754c6dac0ccaf32c97a27d
Autor:
Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Adrianna Wysocka, Anna Stepniewska, Grazyna Niewiadomska
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Parkinson's disease (PD) is manifested by progressive motor, autonomic, and cognitive disturbances. Dopamine (DA) synthesizing neurons in the substantia nigra (SN) degenerate, causing a decline in DA level in the striatum that leads to the characteri
Externí odkaz:
https://doaj.org/article/e503892995114a1d8e7de1e442305132
Autor:
Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Anna Mietelska-Porowska, Grazyna Niewiadomska
Publikováno v:
Neural Plasticity, Vol 2019 (2019)
Physical training confers protection to dopaminergic neurons in rodent models of parkinsonism produced by neurotoxins. The sparing effect of physical training on dopaminergic neurons can be tested with training applied during chronic MPTP treatment,
Externí odkaz:
https://doaj.org/article/a37ad5cae2934e52a8aab957ab0fb071
Publikováno v:
Life, Vol 11, Iss 1, p 28 (2021)
Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It seems that neurofibrillar tangles (NFTs) themselves, d
Externí odkaz:
https://doaj.org/article/f1a2b19e9c114a508d99f6d43f323e18
Autor:
Ewelina Palasz, Adrianna Wysocka, Anna Gasiorowska, Malgorzata Chalimoniuk, Wiktor Niewiadomski, Grazyna Niewiadomska
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1170 (2020)
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson’s disease (PD), BDNF enhances the survival of dopaminergic neurons, improves dopaminergic neurotransmission and motor performance
Externí odkaz:
https://doaj.org/article/1efc307179474d6a9340704c0c7c86c2
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 3, Pp 4671-4713 (2014)
Tau protein is abundant in the central nervous system and involved in microtubule assembly and stabilization. It is predominantly associated with axonal microtubules and present at lower level in dendrites where it is engaged in signaling functions.
Externí odkaz:
https://doaj.org/article/fb08c057be204a6a962b8ebc4d2e70b5
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2973 (2018)
Parkinson’s disease (PD) is a neurodegenerative disorder caused by insufficient dopamine production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine, which is predominantly produced by the dopaminergic neurons within th
Externí odkaz:
https://doaj.org/article/24bc5b2a5252496dab657d9f6cb7aabf
Publikováno v:
Europe PubMed Central
The trophic effect of continuous intraventricular infusion of nerve growth factor (NGF) on morphology of the basal forebrain (BF) cholinergic neurons was tested in 4- and 28-month-old male Wistar rats. All studies were conducted using behaviorally un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e02d16ffbdd343bbb712d2e47f67d
http://europepmc.org/abstract/med/11051196
http://europepmc.org/abstract/med/11051196
