Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Grażyna Chłoń-Rzepa"'
Autor:
Artur Świerczek, Krzysztof Pociecha, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1090 (2022)
Current treatment strategies of autoimmune diseases (ADs) display a limited efficacy and cause numerous adverse effects. Phosphodiesterase (PDE)4 and PDE7 inhibitors have been studied recently as a potential treatment of a variety of ADs. In this stu
Externí odkaz:
https://doaj.org/article/6229171f68fc4b698ffb605466b18254
Autor:
Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Elżbieta Wyska, Krzysztof Pociecha, Reinoud Gosens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 423 (2022)
Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway n
Externí odkaz:
https://doaj.org/article/a628a0c1f9554f039d360a1729feea03
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 597 (2021)
This study aimed to assess the efficacy and explore the mechanisms of action of a potent phosphodiesterase (PDE)7A and a moderate PDE4B inhibitor GRMS-55 in a mouse model of autoimmune hepatitis (AIH). The concentrations of GRMS-55 and relevant bioma
Externí odkaz:
https://doaj.org/article/609c476067c8494e8b794168fc7ec429
Publikováno v:
Postępy Polskiej Medycyny i Farmacji. 9:1-8
The search for new drugs in the treatment of cognitive and mood disorders belongs to the leading research directions due to the growing prevalence of dementia and depression. The limited therapeutic efficacy of substances with a selective mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44da3acb9f6d53e27fb0de905c1ac7db
https://doi.org/10.5604/01.3001.0015.7725
https://doi.org/10.5604/01.3001.0015.7725
Autor:
Katarzyna Wójcik-Pszczoła, Krzysztof Pociecha, Grażyna Chłoń-Rzepa, Monika Zadrożna, Barbara Nowak, Hanna Plutecka, Paulina Koczurkiewicz-Adamczyk, Katarzyna Przejczowska-Pomierny, Elżbieta Pękala, Reinoud Gosens, Elżbieta Wyska
Publikováno v:
International Immunopharmacology. 119:110264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357155800b040dca0b5df7cced896961
https://doi.org/10.1016/j.intimp.2023.110264
https://doi.org/10.1016/j.intimp.2023.110264
Autor:
Agnieszka Jankowska, Grażyna Chłoń-Rzepa, Andrzej J. Bojarski, Maciej Pawłowski, Grzegorz Satała
Publikováno v:
Current Medicinal Chemistry. 28:1731-1745
Alzheimer’s disease (AD) belongs to the most common forms of dementia that causes a progressive loss of brain cells and leads to memory impairment and decline of other thinking skills. There is yet no effective treatment for AD; hence, the search f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4415e6d984269771a643df154a780b0d
https://doi.org/10.2174/0929867327666200427100453
https://doi.org/10.2174/0929867327666200427100453
Publikováno v:
Current Medicinal Chemistry. 27:5351-5373
Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by cognitive impairments such as memory loss, decline in language skills, and disorientation that affects over 46 million people worldwide. Patients with AD also suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc08961dcc4685a4cbd4f5af77f64de9
https://doi.org/10.2174/0929867326666190620095623
https://doi.org/10.2174/0929867326666190620095623
Autor:
Małgorzata Zygmunt, Marietta Ślusarczyk, Agnieszka Jankowska, Artur Świerczek, Adrian Bryła, Szczepan Mogilski, Grzegorz Kazek, Jacek Sapa, Elżbieta Wyska, Grażyna Chłoń-Rzepa
BackgroundTo verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential Ankyrin 1 (TRPA1) channel and phosphodiesterases (PDEs) 4B/7A activity, we continued our pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c7fb7310db6c5b7ab4d7c41a3ab8f
https://ruj.uj.edu.pl/xmlui/handle/item/298315
https://ruj.uj.edu.pl/xmlui/handle/item/298315
Autor:
Bogdan Jakiela, Artur Świerczek, Krzysztof Pociecha, Reinoud Gosens, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Hanna Plutecka, Elżbieta Pękala, Marietta Ślusarczyk, Elżbieta Wyska, Paulina Koczurkiewicz-Adamczyk, Justyna Popiół, Katarzyna Wójcik-Pszczoła
Publikováno v:
Bioorganic Chemistry, 117:105409
Phosphodiesterase (PDE) inhibitors are currently an extensively studied group of compounds that can bring many benefits in the treatment of various inflammatory and fibrotic diseases, including asthma. Herein, we describe a series of novel N’-pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d8daa588fcc68db8ec4923be786aeb
https://research.rug.nl/en/publications/7af6f496-24d0-4a3f-b296-70879261c356
https://research.rug.nl/en/publications/7af6f496-24d0-4a3f-b296-70879261c356
Autor:
Katarzyna Wójcik-Pszczoła, Małgorzata Szafarz, Krzysztof Pociecha, Karolina Słoczyńska, Kamil Piska, Paulina Koczurkiewicz-Adamczyk, Natalia Kocot, Grażyna Chłoń-Rzepa, Elżbieta Pękala, Elżbieta Wyska
Publikováno v:
Toxicology and Applied Pharmacology. 457:116318
Phosphodiesterase (PDE) inhibitors represent a wide class of chemically different compounds that have been extensively studied in recent years. Their anti-inflammatory and anti-fibrotic effects are particularly desirable in the treatment of chronic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356fd2d5692af62354e49bd85e19d9f3
https://doi.org/10.1016/j.taap.2022.116318
https://doi.org/10.1016/j.taap.2022.116318