Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Graça Varzim"'
Autor:
Catarina Santos, Deolinda Pereira, H. Rodrigues, Maria José Bento, Natália Salgueiro, Graça Varzim, Maria J. Soares, Ana Peixoto, António Fráguas, Manuel R. Teixeira, Graça Moura, Fernando Regateiro, Sérgio Castedo, Patrícia Rocha
Publikováno v:
Familial Cancer. 5:379-387
We present the first characterisation of the mutational spectrum of the entire coding sequences and exon–intron boundaries of the BRCA1 and BRCA2 genes as well as large BRCA1 rearrangements in Portuguese families with inherited predisposition to br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2755e9813c2806ab48eea21f5571be
https://doi.org/10.1007/s10689-006-0009-5
https://doi.org/10.1007/s10689-006-0009-5
Autor:
Graça Varzim, Jorge Oliveira, Carlos Lopes, David Sidransky, Carmen Jerónimo, Manuel R. Teixeira, Mohammad O. Hoque, Elizabeth Mambo, Franclim R. Ribeiro, Rui Henrique
Publikováno v:
Clinical Cancer Research. 10:8472-8478
Purpose: Promoter hypermethylation is an alternative pathway for gene silencing in neoplastic cells and a promising cancer detection marker. Although quantitative methylation-specific PCR (QMSP) of the GSTP1 promoter has demonstrated near perfect spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25e4d73215b83b5841736544e4a4d81
https://doi.org/10.1158/1078-0432.ccr-04-0894
https://doi.org/10.1158/1078-0432.ccr-04-0894
Publikováno v:
Cancer Detection and Prevention. 28:237-243
Altered Cyclin D1 activity, due to gene amplification and/or protein overexpression, is related to the development of several human cancers, including head and neck SCC. This study investigated the relationship between CCND1 A870G gene polymorphism a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9e0d7146d86c92b14a6fdde64b179e
https://doi.org/10.1016/j.cdp.2004.04.005
https://doi.org/10.1016/j.cdp.2004.04.005
Publikováno v:
ORL. 64:206-212
Our aim was to examine the role of NAT1 and NAT2 polymorphisms in human larynx cancer susceptibility. Genotype tests for NAT1 alleles *4, *10 and *11, and NAT2 alleles *4, *5, *6A and *7A, using PCR-RFLP analysis, were performed in 172 healthy Portug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a2e30cc6987b29a263e54bb1673fe9
https://doi.org/10.1159/000058026
https://doi.org/10.1159/000058026
Autor:
Carlos Lopes, Shuji Nomoto, Carmen Jerónimo, David Sidransky, Rui Henrique, Otavia L. Caballero, Makiko Fliss, Jorge Oliveira, Henning Usadel, Graça Varzim
Publikováno v:
Oncogene. 20:5195-5198
We recently demonstrated the existence of specific patterns of somatic mitochondrial DNA (mtDNA) mutations in several cancers. Here we sought to identify the presence of mtDNA mutations in prostate cancer and their paired PIN lesions. The D-loop regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a709da7de6e705507a9625def340aad4
https://doi.org/10.1038/sj.onc.1204646
https://doi.org/10.1038/sj.onc.1204646
Autor:
Carmen, Jerónimo, Graça, Varzim, Rui, Henrique, Jorge, Oliveira, Maria José, Bento, Cristina, Silva, Carlos, Lopes, David, Sidransky
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 11(5)
The GSTP1 gene encodes for an enzyme, glutathione S-transferase pi (GSTpi),involved in detoxification of carcinogens. An aminoacid substitution (I105V) in GSTP1 produces a variant enzyme with lower activity and less capability of effective detoxifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cb089b40eecf202ebf846a2321e049a
https://pubmed.ncbi.nlm.nih.gov/12010858
https://pubmed.ncbi.nlm.nih.gov/12010858