High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages.

Autor: Terán G; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden., Li H; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden., Catrina SB; Department of Molecular Medicine and Surgery, Karolinska Institutegrid.4714.6t, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Center for Diabetes, Academic Specialist Center, Stockholm, Sweden., Liu R; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden., Brighenti S; Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutegrid.4714.6t, Stockholm, Sweden., Zheng X; Department of Molecular Medicine and Surgery, Karolinska Institutegrid.4714.6t, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden., Grünler J; Department of Molecular Medicine and Surgery, Karolinska Institutegrid.4714.6t, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden., Nylén S; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden., Carow B; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden., Rottenberg ME; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutegrid.4714.6t, Stockholm Sweden.

Publikováno v: MBio [mBio] 2022 Oct 26; Vol. 13 (5), pp. e0108622. Date of Electronic Publication: 2022 Sep 19.

Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.

Autor: Zheng X; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Narayanan S; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Xu C; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eliasson Angelstig S; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Grünler J; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Zhao A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Di Toro A; Centre for Inherited Cardiovascular Diseases, IRCCS Foundation University Hospital Policlinico San Matteo, Pavia, Italy., Bernardi L; Folkälsan Research Center, Folkälsan Institute of Genetics, University of Helsinki, Helsinki, Finland., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB); Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Katholieke Universiteit (KU) Leuven; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium., Del Sole M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Solaini G; Dipartimento di Biochimica, Università di Bologna, Bologna, Italy., Forsberg EA; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Zhang A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Brismar K; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Schiffer TA; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Rajamand Ekberg N; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden.; Center for Diabetes, Academic Specialist Centrum, Stockholm, Sweden., Botusan IR; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden.; Center for Diabetes, Academic Specialist Centrum, Stockholm, Sweden., Palm F; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Catrina SB; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden.; Center for Diabetes, Academic Specialist Centrum, Stockholm, Sweden.

Publikováno v: ELife [Elife] 2022 Feb 15; Vol. 11. Date of Electronic Publication: 2022 Feb 15.

miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes.

Autor: Li D; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden., Peng H; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA; MirnaTech International, LLC, Detroit, Michigan, USA., Qu L; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA., Sommar P; Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm, Sweden., Wang A; Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China., Chu T; Department of Wound Repair, The Second Hospital of Dalian Medical University, Dalian, China., Li X; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden., Bi X; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA., Liu Q; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA., Gallais Sérézal I; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medical Genetics, Hôpital Henri Mondor, APHP, Créteil, France., Rollman O; Department of Dermatology, Academic University Hospital, Uppsala, Sweden., Lohcharoenkal W; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden., Zheng X; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden., Eliasson Angelstig S; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden., Grünler J; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden., Pivarcsi A; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Medical Biochemistry and Microbiology (IMBIM), Uppsala University, Uppsala, Sweden., Sonkoly E; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden., Catrina SB; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden; Centrum for Diabetes, Academic Specialist Centrum, Stockholm, Sweden., Xiao C; Department of Immunology and Microbiology, The Scripps Research Institute, San Diego, California, USA., Ståhle M; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden., Mi QS; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA., Zhou L; Department of Dermatology, Center for Cutaneous Biology and Immunology Research, Henry Ford Health System, Detroit, Michigan, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA., Xu Landén N; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden; Ming Wai Lau Centre for Reparative Medicine, Stockholm node, Karolinska Institute, Stockholm, Sweden. Electronic address: ning.xu@ki.se.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2021 Mar; Vol. 141 (3), pp. 659-671. Date of Electronic Publication: 2020 Sep 16.

HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism.

Autor: Narayanan S; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Eliasson Angelstig S; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Xu C; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Grünler J; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Zhao A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Zhu W; Department of Nosocomial Infection Control, China Medical University, Shenyang, China., Xu Landén N; Dermatology and Venereology division, Department of Medicine Solna, Center for Molecular Medicine and Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Stockholm, Sweden., Ståhle M; Dermatology and Venereology division, Department of Medicine Solna, Center for Molecular Medicine and Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Stockholm, Sweden., Zhang J; Department of Infectious Disease, China Medical University, Shenyang, China., Ivan M; Departments of Medicine, Microbiology and Immunology, Indiana University, Indianapolis, IN, USA., Maltesen RG; Department of Anesthesia and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark., Botusan IR; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Rajamand Ekberg N; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden., Zheng X; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Xiaowei.zheng@ki.se.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden. Xiaowei.zheng@ki.se., Catrina SB; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Sergiu-Bogdan.Catrina@ki.se.; Department of Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden. Sergiu-Bogdan.Catrina@ki.se.; Center for Diabetes, Academic Specialist Centrum, Stockholm, Sweden. Sergiu-Bogdan.Catrina@ki.se.

Publikováno v: Communications biology [Commun Biol] 2020 Dec 14; Vol. 3 (1), pp. 768. Date of Electronic Publication: 2020 Dec 14.

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

Autor: Zheng X; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden; xiaowei.zheng@ki.se Sergiu-Bogdan.Catrina@ki.se.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Narayanan S; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Sunkari VG; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden., Eliasson S; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Botusan IR; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Grünler J; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Catrina AI; Department of Rheumatology, Karolinska University Hospital Solna, 17176 Stockholm, Sweden., Radtke F; Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland., Xu C; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Zhao A; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden., Ekberg NR; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden., Lendahl U; Department of Cell and Molecular Biology, Karolinska Institutet, 17165 Stockholm, Sweden., Catrina SB; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden; xiaowei.zheng@ki.se Sergiu-Bogdan.Catrina@ki.se.; Department of Endocrinology and Diabetes, Karolinska University Hospital, 17176 Stockholm, Sweden.; Center for Diabetes, Academic Specialist Centrum, 11365 Stockholm, Sweden.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 02; Vol. 116 (14), pp. 6985-6994. Date of Electronic Publication: 2019 Mar 18.