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KDM5B predicts temozolomide-resistant subclones in glioblastoma.

Autor: Ullrich V; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Ertmer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Baginska A; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Dorsch M; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Gull HH; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Cima I; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Berger P; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Dobersalske C; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Langer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Meyer L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Dujardin P; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Kebir S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany.; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, 45147 Essen, Germany., Glas M; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany.; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, 45147 Essen, Germany., Blau T; Department of Neuropathology, University Hospital Essen, 45147 Essen, Germany., Keyvani K; Department of Neuropathology, University Hospital Essen, 45147 Essen, Germany., Rauschenbach L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Sure U; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Roesch A; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Dermatology, University Hospital Essen, 45147 Essen, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany., Grüner BM; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany.

Publikováno v: IScience [iScience] 2023 Dec 03; Vol. 27 (1), pp. 108596. Date of Electronic Publication: 2023 Dec 03 (Print Publication: 2024).

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma.

Autor: Kebir S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Ullrich V; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Berger P; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Dobersalske C; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Langer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Rauschenbach L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Trageser D; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany.; LIFE & BRAIN GmbH, Cellomics Unit, Bonn, Germany., Till A; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Lorbeer FK; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Wieland A; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Wilhelm-Buchstab T; Department of Radiology, University of Bonn Medical Center, Bonn, Germany., Ahmad A; Bonn-Aachen International Center for IT (B-IT), University of Bonn, Bonn, Germany., Fröhlich H; Bonn-Aachen International Center for IT (B-IT), University of Bonn, Bonn, Germany.; Department of Bioinformatics, Fraunhofer SCAI, Schloss Birlinghoven, Sankt Augustin, Germany., Cima I; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Prasad S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Matschke J; Institute of Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany., Jendrossek V; Institute of Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany., Remke M; German Cancer Consortium (DKTK).; Pediatric Neuro-Oncogenomics, University Hospital Düsseldorf, Düsseldorf, Germany., Grüner BM; German Cancer Consortium (DKTK).; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Roesch A; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Dermatology, University Hospital Essen, Essen, Germany., Siveke JT; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Herold-Mende C; Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany., Blau T; Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany., Keyvani K; Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany., van Landeghem FKH; Institute of Neuropathology, University of Bonn, Bonn, Germany., Pietsch T; Institute of Neuropathology, University of Bonn, Bonn, Germany., Felsberg J; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany., Reifenberger G; German Cancer Consortium (DKTK).; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany., Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland., Sure U; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Brüstle O; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany.; LIFE & BRAIN GmbH, Cellomics Unit, Bonn, Germany., Simon M; Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.; Department of Neurosurgery, Bethel Clinic, University of Bielefeld Medical Center, OWL, Bielefeld, Germany., Glas M; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, Essen, Germany.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jan 17; Vol. 29 (2), pp. 488-500.

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.

Autor: Dorsch M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Kowalczyk M; Department of Molecular Cell Biology, Center for Medical Biotechnology, University of Duisburg-Essen, Duisburg, Germany., Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Heilmann G; Department of Chemical Biology, Center for Medical Biotechnology, University of Duisburg-Essen, Duisburg, Germany., Urban S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Dujardin P; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Forster J; Department of Genome Informatics, Institute for Human Genetics, University of Duisburg-Essen, Duisburg, Germany; German Cancer Consortium (DKTK) partner site Essen, Essen, Germany., Ueffing K; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Nothdurft S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Oeck S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Paul A; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Liffers ST; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, Essen, Germany., Kaschani F; Department of Chemical Biology, Center for Medical Biotechnology, University of Duisburg-Essen, Duisburg, Germany., Kaiser M; Department of Chemical Biology, Center for Medical Biotechnology, University of Duisburg-Essen, Duisburg, Germany., Schramm A; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany., Siveke JT; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, Essen, Germany; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany., Winslow MM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Nalbant P; Department of Molecular Cell Biology, Center for Medical Biotechnology, University of Duisburg-Essen, Duisburg, Germany., Grüner BM; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany; German Cancer Consortium (DKTK) partner site Essen, Essen, Germany. Electronic address: barbara.gruener@uk-essen.de.

Publikováno v: Cell reports [Cell Rep] 2021 Nov 23; Vol. 37 (8), pp. 110056.

Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability.

Autor: Chuang CH; Department of Genetics, Stanford University School of Medicine, Stanford, California., Dorsch M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany., Dujardin P; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany., Silas S; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California., Ueffing K; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany., Hölken JM; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany., Yang D; Cancer Biology Program, Stanford University School of Medicine, Stanford, California., Winslow MM; Department of Genetics, Stanford University School of Medicine, Stanford, California.; Cancer Biology Program, Stanford University School of Medicine, Stanford, California.; Department of Pathology, Stanford University School of Medicine, Stanford, California.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California., Grüner BM; Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University of Duisburg-Essen, Essen, Germany. Barbara.gruener@uk-essen.de.; German Cancer Consortium (DKTK) partner site Essen, Essen, Germany.

Publikováno v: Cancer research [Cancer Res] 2021 Feb 01; Vol. 81 (3), pp. 567-579. Date of Electronic Publication: 2020 Nov 25.