CRISPR/Cas9-mediated rescue of osteoclast function in a stem cell-based disease model for osteopetrosis

Autor: Gajewski, Dario, Hennig, Anna Floriane, Rössler, Uta, Grün, Regina, Cyganek, Lukas, Stachelscheid, Harald, Kornak, Uwe

Publikováno v: In Bone Reports May 2022 16 Supplement

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

Autor: Prokakis, Evangelos, Dyas, Anna, Grün, Regina, Fritzsche, Sonja, Bedi, Upasana, Kazerouni, Zahra B, Kosinsky, Robyn L, Johnsen, Steven A, Wegwitz, Florian

The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called "death-from-cancer" signature predicting therapy failure in cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9f5aed1c7d19dae8bc550f4cdc74d4

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.

Autor: Prokakis E; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Dyas A; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK., Grün R; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Fritzsche S; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany., Bedi U; Chromatin Remodeling Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 110067., Kazerouni ZB; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Kosinsky RL; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA., Johnsen SA; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. johnsen.steven@mayo.edu.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. johnsen.steven@mayo.edu., Wegwitz F; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.

Publikováno v: Oncogene [Oncogene] 2021 Jun; Vol. 40 (23), pp. 4004-4018. Date of Electronic Publication: 2021 May 18.