Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics

Autor: Gröer, C., Busch, D., Patrzyk, M., Beyer, K., Busemann, A., Heidecke, C.D., Drozdzik, M., Siegmund, W., Oswald, S.

Publikováno v: In Journal of Pharmaceutical and Biomedical Analysis November 2014 100:393-401

Protein abundance of clinically relevant metabolizing enzymes along the human intestine

Autor: Busch, D, Gröer, C, Busemann, A, Partecke, LI, Heidecke, CD, Siegmund, W, Oswald, S

Publikováno v: 17. Jahreskongress für Klinische Pharmakologie; 20151001-20151002; Köln; DOC15vklipha19 /20150924/

Background: The pharmacokinetics of most drugs on the market is markedly influenced by intestinal and hepatic biotransformation enzymes such as cytochrome P450 (CYP450) enzymes and UDP-glucuronosyltransferases (UGT). In order to predict their impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75fcc9049ab3d5c4cf90e2695b7de1e

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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

Autor: Wegler C; Department of Pharmacy, Uppsala University , Uppsala 75123, Sweden.; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D , Mölndal 431 50, Sweden., Gaugaz FZ; Department of Pharmacy, Uppsala University , Uppsala 75123, Sweden., Andersson TB; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D , Mölndal 431 50, Sweden., Wiśniewski JR; Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry , Martinsried 82152, Germany., Busch D; Center of Drug Absorption and Transport, Department of Clinical Pharmacology, University Medicine of Greifswald , Greifswald 17489, Germany., Gröer C; Center of Drug Absorption and Transport, Department of Clinical Pharmacology, University Medicine of Greifswald , Greifswald 17489, Germany., Oswald S; Center of Drug Absorption and Transport, Department of Clinical Pharmacology, University Medicine of Greifswald , Greifswald 17489, Germany., Norén A; Department of Surgical Sciences, Uppsala University , Uppsala 75185, Sweden., Weiss F; NMI Natural and Medical Sciences Institute, University of Tübingen , Reutlingen 72770, Germany., Hammer HS; NMI Natural and Medical Sciences Institute, University of Tübingen , Reutlingen 72770, Germany., Joos TO; NMI Natural and Medical Sciences Institute, University of Tübingen , Reutlingen 72770, Germany., Poetz O; NMI Natural and Medical Sciences Institute, University of Tübingen , Reutlingen 72770, Germany., Achour B; Centre for Applied Pharmacokinetic Research, University of Manchester , Manchester M13 9PL, United Kingdom., Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, University of Manchester , Manchester M13 9PL, United Kingdom., van de Steeg E; TNO (Netherlands Organization for Applied Scientific Research) , 3700 AJ Zeist, Netherlands., Wortelboer HM; TNO (Netherlands Organization for Applied Scientific Research) , 3700 AJ Zeist, Netherlands., Artursson P; Department of Pharmacy, Uppsala University , Uppsala 75123, Sweden.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2017 Sep 05; Vol. 14 (9), pp. 3142-3151. Date of Electronic Publication: 2017 Aug 16.

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