Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Grégory Verdon"'
Publikováno v:
eLife, Vol 3 (2014)
Membrane transporters that clear the neurotransmitter glutamate from synapses are driven by symport of sodium ions and counter-transport of a potassium ion. Previous crystal structures of a homologous archaeal sodium and aspartate symporter showed th
Externí odkaz:
https://doaj.org/article/98e090346a794076ac026276b600e314
Autor:
María Majellaro, Robert M. Cooke, Andrei Zhukov, Andrew S. Doré, Francesca Deflorian, Henrik Keränen, Hugo Gutiérrez-de-Terán, Grégory Verdon, Miles Congreve, Johan Åqvist, Eddy Sotelo, Jhonny Azuaje, Xerardo García-Mera, Chris de Graaf, Willem Jespers, Jonathan S. Mason
Publikováno v:
Angewandte Chemie (International Ed. in English)
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
We present a robust protocol based on iterations of free energy perturbation (FEP) calculations, chemical synthesis, biophysical mapping and X‐ray crystallography to reveal the binding mode of an antagonist series to the A2A adenosine receptor (AR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb82a0e9f21ff3cb50f65224bd63c71
https://doi.org/10.1002/anie.202003788
https://doi.org/10.1002/anie.202003788
Autor:
Tasia, Amelia, Jacobus P D, van Veldhoven, Matteo, Falsini, Rongfang, Liu, Laura H, Heitman, Gerard J P, van Westen, Elena, Segala, Grégory, Verdon, Robert K Y, Cheng, Robert M, Cooke, Daan, van der Es, Adriaan P, IJzerman
Publikováno v:
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1106f4cb522305aba0e4d49b33d5633
https://pubmed.ncbi.nlm.nih.gov/33764785
https://pubmed.ncbi.nlm.nih.gov/33764785
Autor:
Tasia Amelia, Robert K. Y. Cheng, Gerard J. P. van Westen, Rongfang Liu, Elena Segala, Robert M. Cooke, Laura H. Heitman, Jacobus P. D. van Veldhoven, Daan van der Es, Matteo Falsini, Grégory Verdon, Adriaan P. IJzerman
Publikováno v:
Journal of Medicinal Chemistry, 64(7), 3827-3842. American Chemical Society (ACS)
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eaee9ee24339f7b4772a78e3323223
http://hdl.handle.net/1887/3204468
http://hdl.handle.net/1887/3204468
Autor:
Willem Jespers, Grégory Verdon, Jhonny Azuaje, Maria Majellaro, Henrik Keränen, Xerardo García‐Mera, Miles Congreve, Francesca Deflorian, Chris Graaf, Andrei Zhukov, Andrew S. Doré, Jonathan S. Mason, Johan Åqvist, Robert M. Cooke, Eddy Sotelo, Hugo Gutiérrez‐de‐Terán
Publikováno v:
Angewandte Chemie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca146b014e4b7900d50b48810e73eaa
https://doi.org/10.1002/ange.202003788
https://doi.org/10.1002/ange.202003788
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1713
Identifying membrane proteins that can be produced and isolated in homogenous form in detergent is a lengthy trial-and-error process that can be facilitated by fluorescence-based screening approaches. We describe (1) the strategy and protocol of clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::595a202eadaabd3f0cf7140c9f8939e4
https://pubmed.ncbi.nlm.nih.gov/29218515
https://pubmed.ncbi.nlm.nih.gov/29218515
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975068
Identifying membrane proteins that can be produced and isolated in homogenous form in detergent is a lengthy trial-and-error process that can be facilitated by fluorescence-based screening approaches. We describe (1) the strategy and protocol of clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f01022e4784311a454c0092e2e200b0
https://doi.org/10.1007/978-1-4939-7507-5_3
https://doi.org/10.1007/978-1-4939-7507-5_3
Autor:
Hitomi Abe, Tomoya Hino, Saba Abdul Hussien, Takeshi Murata, Takatoshi Arakawa, Takao Hamakubo, Grégory Verdon, Michihiro Kasahara, Hiroko Iwanari, Hae Joo Kang, Yumi Sato, Mathieu Coincon, Yayoi Nomura, Yo Sonoda, Norimichi Nomura, So Iwata, Yoshiko Nakada-Nakura, Aziz Abdul Qureshi, Tatsuro Shimamura, Takuya Kobayashi, David A. Drew, Osamu Kusano-Arai
Publikováno v:
Nature
The altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity. GLUT5 is also overexpressed in certain tumour cells, and inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973c012950a3a81f8ba537b1a0260135
http://europepmc.org/articles/PMC4618315
http://europepmc.org/articles/PMC4618315
Autor:
Olga Boudker, Grégory Verdon
Publikováno v:
Trends in Pharmacological Sciences. 31:418-426
Secondary active transporters catalyze concentrative transport of substrates across lipid membranes by harnessing the energy of electrochemical ion gradients. These transporters bind their ligands on one side of the membrane, and undergo a global con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031068a37eb3d33f494f74d29291492b
https://doi.org/10.1016/j.tips.2010.06.004
https://doi.org/10.1016/j.tips.2010.06.004
Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus
Autor:
Bauke W. Dijkstra, Andy-Mark W. H. Thunnissen, Arnold J. M. Driessen, Sonja V. Albers, Grégory Verdon
Publikováno v:
Journal of Molecular Biology, 330(2), 343-358. Academic Press
The ABC-ATPase GlcV energizes a binding protein-dependent ABC transporter that mediates glucose uptake in Sulfolobus solfataricus. Here, we report high-resolution crystal structures of GlcV in different states along its catalytic cycle: distinct mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39430053b65544751c742923df604153
https://hdl.handle.net/11370/b6b02f2c-f3bd-4dea-928c-a39313fd07bc
https://hdl.handle.net/11370/b6b02f2c-f3bd-4dea-928c-a39313fd07bc