Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Grégory Upert"'
Autor:
Sean B. Christensen, Arik J. Hone, Isabelle Roux, Julie Kniazeff, Jean-Philippe Pin, Grégory Upert, Denis Servent, Elisabeth Glowatzki, J. Michael McIntosh
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere their roles are less well-understood. α9α
Externí odkaz:
https://doaj.org/article/d503abc27d6140c593cd2e5a9d1858ea
Autor:
Steve Reynaud, Suli-Anne Laurin, Justyna Ciolek, Peggy Barbe, Anne-Cécile Van Baelen, Michaël Susset, Florian Blondel, Marine Ghazarian, Julia Boeri, Margot Vanden Driessche, Grégory Upert, Gilles Mourier, Pascal Kessler, Laure Konnert, Rémy Beroud, Mathilde Keck, Denis Servent, Michel Bouvier, Nicolas Gilles
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (18), pp.12084-12094. ⟨10.1021/acs.jmedchem.2c00786⟩
Journal of Medicinal Chemistry, 2022, 65 (18), pp.12084-12094. ⟨10.1021/acs.jmedchem.2c00786⟩
International audience; The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonist
Autor:
Matthias Schuster, Emile Brabet, Kathryn K. Oi, Nicolas Desjonquères, Kerstin Moehle, Karen Le Poupon, Sophie Hell, Stéphane Gable, Virginie Rithié, Séverine Dillinger, Peter Zbinden, Anatol Luther, Claudia Li, Sarah Stiegeler, Carolin D’Arco, Hans Locher, Tobias Remus, Selena DiMaio, Paola Motta, Achim Wach, Françoise Jung, Grégory Upert, Daniel Obrecht, Mohammed Benghezal, Oliver Zerbe
The rise of antimicrobial resistance poses a substantial threat to our health system, and, hence, development of drugs against novel targets is urgently needed. The natural peptide thanatin kills Gram-negative bacteria by targeting proteins of the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdb6b0f3d20d6adce41eaab9c437bef
https://www.zora.uzh.ch/id/eprint/234370/
https://www.zora.uzh.ch/id/eprint/234370/
Autor:
Selen Manioglu, Seyed Majed Modaresi, Johannes Thoma, Sarah A. Overall, Gregory Upert, Anatol Luther, Alexander B. Barnes, Daniel Obrecht, Daniel J. Müller, Sebastian Hiller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/28d1b793f563437193c5331af1142178
Autor:
Selen Manioglu, Seyed Majed Modaresi, Noah Ritzmann, Johannes Thoma, Sarah A. Overall, Alexander Harms, Gregory Upert, Anatol Luther, Alexander B. Barnes, Daniel Obrecht, Daniel J. Müller, Sebastian Hiller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but mechanistic details at the molecular level remain unclear. Here, we c
Externí odkaz:
https://doaj.org/article/0539de9771d743a08fee0604262fc708
Publikováno v:
Medicine in Drug Discovery, Vol 9, Iss , Pp 100078- (2021)
This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear a
Externí odkaz:
https://doaj.org/article/14cc5142df3b4c558e756529d38b8930
Autor:
Guillaume Blanchet, Doria Alili, Adèle Protte, Gregory Upert, Nicolas Gilles, Livia Tepshi, Enrico A. Stura, Gilles Mourier, Denis Servent
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles. In order to generate novel functions on th
Externí odkaz:
https://doaj.org/article/6cf6bae70a12426a85f6c165e6b9fabf
Autor:
Gregory Upert, Audrey Di Giorgio, Alok Upadhyay, Dinesh Manvar, Nootan Pandey, Virendra N. Pandey, Nadia Patino
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
Human immunodeficiency virus-1 (HIV-1) replication and gene expression entails specific interaction of the viral protein Tat with its transactivation responsive element (TAR), to form a highly stable stem-bulge-loop structure. Previously, we describe
Externí odkaz:
https://doaj.org/article/068824744f014247b53d9f5ae7da8f58