Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Grégoire Rondelet"'
Publikováno v:
Crystals, Vol 6, Iss 11, p 153 (2016)
While mechanosynthesis of the target compound, 1-[2-(1H-indol-3-yl)-ethyl]-pyrrole-2,5-dione, C14 H12 N2 O2, did not yield the desired product, it instead resulted in an open intermediate. On the other hand, synthesis starting from the activated male
Externí odkaz:
https://doaj.org/article/39cfe9f9910343fba9c9c57b84d4bf85
Publikováno v:
Rondelet, G, Dal Maso, T, Willems, L & Wouters, J 2016, ' Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B ', Journal of Structural Biology, vol. 194, 3, pp. 357–367 . https://doi.org/10.1016/j.jsb.2016.03.013
DNA methylation is an important epigenetic modification involved in chromatin organization and gene expression. The function of DNA methylation depends on cell context and is correlated with histone modification patterns. In particular, trimethylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93abd633142317b1a5b816e9d15342a0
Autor:
Jean-Michel Dogné, Charlotte Bouckaert, Raphaël Frédérick, Johan Wouters, Eduard Dolusic, Silvia Serra, Grégoire Rondelet, Lionel Pochet
Publikováno v:
European journal of medicinal chemistry / Chimica therapeutica. :181-194
Inhibitors of the coagulation factor XIIa (FXIIa) are attractive to detail the roles of this protease in hemostasis and thrombosis, to suppress artifact due to contact pathway activation in blood coagulation assays, and they are promising as antithro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51080a2a4a68a85f672327eaa27d16c6
https://researchportal.unamur.be/en/publications/2c4677ba-0468-4022-8296-89a37cf2c499
https://researchportal.unamur.be/en/publications/2c4677ba-0468-4022-8296-89a37cf2c499
Autor:
Céline Faux, Johan Wouters, Grégoire Rondelet, Véronique Masson, Paola B. Arimondo, Jean Dubois, Laurence Fleury, Luc Willems
Publikováno v:
Future Medicinal Chemistry
Future Medicinal Chemistry, Future Science, 2017, 9 (13), pp.1465-1481. ⟨10.4155/fmc-2017-0074⟩
Future Medicinal Chemistry, Future Science, 2017, 9 (13), pp.1465-1481. ⟨10.4155/fmc-2017-0074⟩
Aim: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd20bb0670ff106f4bc18abd08f8abf
https://pubmed.ncbi.nlm.nih.gov/28795598
https://pubmed.ncbi.nlm.nih.gov/28795598
Autor:
Johan Wouters, Grégoire Rondelet
Publikováno v:
Biochimie. 139
Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a983cb7e7cb8a2c6e29ab8b80e1ac3
https://pubmed.ncbi.nlm.nih.gov/28600135
https://pubmed.ncbi.nlm.nih.gov/28600135
Publikováno v:
Crystals, Vol 6, Iss 11, p 153 (2016)
Dubois, J, Colaço, M, Rondelet, G & Wouters, J 2016, ' Synthesis and Crystallographic Characterization of a Maleimide Derivative of Tryptamine ', Crystals, vol. 6 . https://doi.org/10.3390/cryst6110153
Dubois, J, Colaço, M, Rondelet, G & Wouters, J 2016, ' Synthesis and Crystallographic Characterization of a Maleimide Derivative of Tryptamine ', Crystals, vol. 6 . https://doi.org/10.3390/cryst6110153
While mechanosynthesis of the target compound, 1-[2-(1H-indol-3-yl)-ethyl]-pyrrole-2,5-dione, C14 H12 N2 O2, did not yield the desired product, it instead resulted in an open intermediate. On the other hand, synthesis starting from the activated male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75955bcc0cb16f0b78372f46838afa6a
https://researchportal.unamur.be/en/publications/870e6492-eab2-435a-a0df-fa88f3ba7b2b
https://researchportal.unamur.be/en/publications/870e6492-eab2-435a-a0df-fa88f3ba7b2b