Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Grégoire Leclair"'
Autor:
Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 872-885 (2023)
Abstract Females present a higher risk of adverse drug reactions. Sex‐related differences in drug concentrations may contribute to these observations but they remain understudied given the underrepresentation of females in clinical trials. The aim
Externí odkaz:
https://doaj.org/article/58f822ad9b2840d0901676770757397e
Autor:
Sabrina Robert, Marc‐Olivier Pilon, Essaïd Oussaïd, Maxime Meloche, Grégoire Leclair, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6. Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the enzyme, such as metoprolol. Considering that both metoprolol and am
Externí odkaz:
https://doaj.org/article/0853f8a5071a463ca8c6f9d55b6c7249
Autor:
Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 2024-2034 (2022)
Abstract ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid
Externí odkaz:
https://doaj.org/article/f9425dbf0f014bcc896fcaa842b04bf7
Autor:
Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 1063-1073 (2022)
Abstract Large, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease‐related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentration
Externí odkaz:
https://doaj.org/article/81b54697e31d490090a5d831aea25000
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cannabis is one of the most widely used illicit drugs during pregnancy and lactation. With the recent legalization of cannabis in many countries, health professionals are increasingly exposed to pregnant and breastfeeding women who are consuming cann
Externí odkaz:
https://doaj.org/article/c33bfb6b77b54d8fbb5ed2bf2d1822ec
Autor:
Daphné Coache, Mihaela Friciu, Ruth Bernine Marcellin, Lola Bonnemain, Annie Viau, V Gaëlle Roullin, Jean-Marc Forest, Grégoire Leclair
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270206 (2022)
This study assessed the stability of six extemporaneously compounded hydroxyurea oral liquids stored at room temperature. Hydroxyurea oral liquids (100 mg/mL) were prepared using three different mixing methods (mortar, mixer or QuartetRx) from either
Externí odkaz:
https://doaj.org/article/e41166bbd25443ffb685ba47696f81ec
Autor:
Daphné Coache, Mihaela Friciu, V Gaëlle Roullin, Marianne Boulé, Jean-Marc Forest, Grégoire Leclair
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260279 (2021)
The present study aimed to assess the stability of clonidine hydrochloride oral liquids (20-μg/mL) prepared from two different generic tablets in Ora-Blend and stored in amber plastic bottles. Physical and chemical stabilities were evaluated over a
Externí odkaz:
https://doaj.org/article/b2f70c5f87b1433795969e25ffac6619
Publikováno v:
MethodsX, Vol 7, Iss , Pp 100844- (2020)
This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension. • The method was modified to allow the quantification of acetazolamide in two new suspension vehicl
Externí odkaz:
https://doaj.org/article/cd4ca3edb7ff4143a901cd6143e8084f
Autor:
Igor Elkin, Thierry Maris, Alexandre Melkoumov, Patrice Hildgen, Xavier Banquy, Grégoire Leclair, Christopher Barrett
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 4, Pp 458-460 (2018)
In the title compound, C17H15N3O3, the plane of the pyrrolidone ring is inclined at an angle of 59.791 (2)° to that of the azobenzene segment, which adopts a configuration close to planar. In the crystal, molecules are oriented pairwise by (2-oxopyr
Externí odkaz:
https://doaj.org/article/608e8eeb68824de3aabe911a44c7882e
Autor:
Florian Bernard-Patrzynski, Marc-André Lécuyer, Ina Puscas, Imane Boukhatem, Marc Charabati, Lyne Bourbonnière, Charles Ramassamy, Grégoire Leclair, Alexandre Prat, V Gaëlle Roullin
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226302 (2019)
Primary cell isolation from the central nervous system (CNS) has allowed fundamental understanding of blood-brain barrier (BBB) properties. However, poorly described isolation techniques or suboptimal cellular purity has been a weak point of some pub
Externí odkaz:
https://doaj.org/article/5124970efe8d4019966a3720a73640a9